estrone and Turner Syndrome studies

Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.

Turner Syndrome: A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.

Research Excerpts

Excerpt	Relevance	Reference
"Our objective was to assess metabolic effects of oral vs transdermal (TD) 17β-E₂ replacement using estrogen concentration-based dosing in girls with Turner syndrome (TS)."	2.78	Metabolic effects of oral versus transdermal 17β-estradiol (E₂): a randomized clinical trial in girls with Turner syndrome. ( Hossain, J; Klein, KO; Mauras, N; Mericq, V; Ross, JL; Santen, RJ; Singh, R; Taboada, M; Torres-Santiago, L; Unanue, N, 2013)
"Estrone was detected in cerebrospinal fluid before and after but not during dexamethasone treatment."	1.26	Pseudotumor cerebri in an obese woman with Turner syndrome. ( Binstock, ML; Donaldson, JO, 1981)
"To evaluate the relationship between the secretion of gonadotropins and adrenal androgens, patients with gonadal agenesis were evaluated by (a) administering human luteinizing hormone (hLH) for 5 days with or without estrogen pretreatment to agonadal patients who had prepubertal LH levels; (b) correlating circulating gonadotropin levels with adrenal androgens in 45 patients; and (c) comparing adrenal androgens with gonadotropins after long-term administration of estrogen or androgens."	1.25	Lack of correlation between gonadotropin and adrenal androgen levels in agonadal children. ( Blizzard, RM; Kowarski, A; Lee, PA; Migeon, CJ, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (86.36)	18.7374
1990's	1 (4.55)	18.2507
2000's	1 (4.55)	29.6817
2010's	1 (4.55)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Torres-Santiago, L	1
Mericq, V	1
Taboada, M	1
Unanue, N	1
Klein, KO	1
Singh, R	1
Hossain, J	1
Santen, RJ	1
Ross, JL	1
Mauras, N	1
Bannink, EM	1
van Sassen, C	1
van Buuren, S	1
de Jong, FH	1
Lequin, M	1
Mulder, PG	1
de Muinck Keizer-Schrama, SM	1
KELLY, LW	1
Reiter, EO	1
Duckett, GE	1
Root, AW	1
Donaldson, JO	2
Horak, E	1
Binstock, ML	1
Lee, PA	1
Kowarski, A	1
Migeon, CJ	1
Blizzard, RM	1
Isaacs, AJ	1
Havard, CW	1
Nagamani, M	1
Lin, TJ	1
McDonough, PG	1
Watatani, H	1
McPherson, JC	1
Mahesh, VB	1
Conte, FA	2
Grumbach, MM	2
Kaplan, SL	2
Toublanc, JE	2
Grenier, J	1
Nahoul, K	1
Scholler, R	2
Canlorbe, P	2
Illig, R	1
DeCampo, C	1
Lang-Muritano, MR	1
Prader, A	1
Torresani, T	1
Werder, EA	1
Willi, U	1
Schenkel, L	1
Stone, D	1
Mackay, AM	1
Pettigrew, N	1
Symington, T	1
Neville, AM	1
Howard, RP	1
Keaty, EC	1
Job, JC	1
Garnier, PE	1
Chaussain, JL	1
Kelch, RP	1
Rosenfield, RL	1
Fang, VS	1
Dupon, C	2
Kim, MH	2
Refetoff, S	1
Bidlingmaier, F	1
Wagner-Barnack, M	1
Butenandt, O	1
Knorr, D	1
Hosseinian, AH	1
Sacris, MO	1
Cleary, RE	1
Nankin, HR	1
Loiudice, T	1
Loraine, JA	1
Adamopoulos, DA	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Estrogen Dosing in Turner Syndrome:Pharmacology & Metabolism[NCT00837616]			Phase 4	41 participants (Actual)	Interventional	2009-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	kg/m2 (Mean)
Oral Estradiol	0.075
Transdermal Estradiol	0.65

Intervention	kg (Mean)
Oral Estradiol	1.03
Transdermal Estradiol	1.67

estrone and Turner Syndrome

Research Excerpts

Research

Studies (22)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change in Body Mass Index From Baseline at 12 Months

Change in Fat Free Mass From Baseline at 12 Months

Change in Percent Fat Mass From Baseline in 12 Months

Change in Weight From Baseline at 12 Months

Changes in Insulin Growth Factor-I From Baseline at 12 Months

Rates of Lipid Oxidation After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

Serum 17B Estradiol Concentrations After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

Serum Estrone Concentrations After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

Serum Estrone Sulfate Concentrations After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

Lipids Concentrations After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

Reviews

Trials

Other Studies

Intervention	mg/dl (Mean)
	Total Cholesterol	Low Density Lipoprotein	High Density Lipoprotein	Triglycerides
Oral Estradiol	168	93	56	95
Transdermal Estradiol	153	88	50	70

Article	Year
Metabolic effects of oral versus transdermal 17β-estradiol (E₂): a randomized clinical trial in girls with Turner syndrome. The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:7 Topics: Administration, Oral; Adolescent; Adult; Basal Metabolism; Biotransformation; Body Composition; Bone	2013
Puberty induction in Turner syndrome: results of oestrogen treatment on development of secondary sexual characteristics, uterine dimensions and serum hormone levels. Clinical endocrinology, 2009, Volume: 70, Issue:2 Topics: Administration, Oral; Adolescent; Breast; Child; Cross-Sectional Studies; Dose-Response Relationship	2009

Article	Year
Ovarian dwarfism with pituitary tumor. The Journal of clinical endocrinology and metabolism, 1963, Volume: 23 Topics: Dwarfism; Estrone; Humans; Hypogonadism; Norethynodrel; Pituitary Neoplasms; Turner Syndrome	1963
Responses to constant infusion of LH-RH in girls with primary hypogonadism. Obstetrics and gynecology, 1980, Volume: 56, Issue:3 Topics: Adolescent; Adult; Androstenedione; Child; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; E	1980
Cerebrospinal fluid oestrone in pseudotumour cerebri. Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:8 Topics: Adult; Cerebrospinal Fluid Proteins; Dexamethasone; Diet, Reducing; Estradiol; Estriol; Estrone; Fem	1982
Pseudotumor cerebri in an obese woman with Turner syndrome. Neurology, 1981, Volume: 31, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Androstenedione; Estrogens; Estrone; Female; Humans; Menstruation; O	1981
Lack of correlation between gonadotropin and adrenal androgen levels in agonadal children. The Journal of clinical endocrinology and metabolism, 1975, Volume: 40, Issue:4 Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androgens; Dehydroepiandrosterone; Estrogens, Conjugated (	1975
Effect of piperazine oestrone sulphate on serum lipids and lipoproteins in menopausal women. Acta endocrinologica, 1977, Volume: 85, Issue:1 Topics: Cholesterol; Climacteric; Estrone; Fatty Acids; Fatty Acids, Nonesterified; Female; Humans; Lipids;	1977
Clinical and endocrine studies in menopausal women after estradiol pellet implantation. Obstetrics and gynecology, 1977, Volume: 50, Issue:5 Topics: Adult; Depression, Chemical; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Lutei	1977
A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis. The Journal of clinical endocrinology and metabolism, 1975, Volume: 40, Issue:4 Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Estradiol; Estrone; Female; Follicle Stimul	1975
[Levels of estrone, estradiol 17 beta and testosterone in girls during normal puberty. Applications in pathology]. Gynecologie, 1975, Volume: 26, Issue:3 Topics: Adolescent; Adult; Child; Child, Preschool; Estradiol; Estrone; Female; Humans; Hypopituitarism; Inf	1975
A physiological mode of puberty induction in hypogonadal girls by low dose transdermal 17 beta-oestradiol. European journal of pediatrics, 1990, Volume: 150, Issue:2 Topics: Administration, Cutaneous; Adolescent; Child; Estradiol; Estrone; Female; Follicle Stimulating Hormo	1990
Tumors of dysgenetic gonads (gonadoblastoma): ultrastructural and steroidogenic aspects. Cancer, 1974, Volume: 34, Issue:4 Topics: 17-alpha-Hydroxypregnenolone; Androstenedione; Androstenes; Basement Membrane; Cell Nucleus; Cytopla	1974
Evaluation of equilin 3-monosulfate and other estrogens. Comparison by study of urinary gonadotropins in women. Archives of internal medicine, 1971, Volume: 128, Issue:2 Topics: 17-Ketosteroids; Administration, Oral; Adult; Aged; Amenorrhea; Animals; Biological Assay; Castratio	1971
Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on the release of gonadotropins in hypophyso-gonadal disorders of children and adolescents. V. Agonadism. The Journal of clinical endocrinology and metabolism, 1974, Volume: 38, Issue:6 Topics: Adolescent; Child; Child, Preschool; Disorders of Sex Development; Estradiol; Estrone; Female; Folli	1974
Episodic secretion of luteinizing hormone (LH) in adolescent patients with the syndrome of gonadal dysgenesis. The Journal of clinical endocrinology and metabolism, 1973, Volume: 36, Issue:3 Topics: Adolescent; Adult; Child; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Iodine I	1973
The effects of low doses of depot estradiol and testosterone in teenagers with ovarian failure and Turner's syndrome. The Journal of clinical endocrinology and metabolism, 1973, Volume: 37, Issue:4 Topics: Adolescent; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Half-Life; Humans; Luteinizing	1973
Plasma estrogens in childhood and puberty under physiologic and pathologic conditions. Pediatric research, 1973, Volume: 7, Issue:11 Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adult; Animals; Cattle; C	1973
Hormonal profile in patients with gonadal dysgenesis. American journal of obstetrics and gynecology, 1974, Apr-01, Volume: 118, Issue:7 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Androstenedione; Chorionic Gonadotropin; Depression, Che	1974
Primary amenorrhea in a 46,XX-46,XXq-female. Obstetrics and gynecology, 1974, Volume: 44, Issue:1 Topics: Adult; Amenorrhea; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Karyotyping; Lu	1974
Recent studies on the estimation of human pituitary gonadotrophins in urine in clinical conditions. Hormones, 1970, Volume: 1, Issue:2 Topics: Adult; Aged; Animals; Ascorbic Acid; Climacteric; Clomiphene; Contraceptives, Oral; Estradiol; Estri	1970