estrone has been researched along with Osteoporosis in 47 studies
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.
Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2-[3-Estrone-N-ethyl-piperazine-methyl] tetracycline (XW630) showing anti-osteoporosis activity is a new compound with piperazine-tetracycline in the steroid structure of estrone." | 7.70 | [The estrogenic activities of 2-[3-estrone-N-ethyl-piperazine-methyl]tetracycline(XW630)--a new compound with anti-osteoporosis activity]. ( Jiao, X; Mo, Z; Su, H; Weng, L; Zheng, H, 1998) |
| "2-[3-Estrone-N-ethyl-piperazine-methyl] tetracycline (XW630) showing anti-osteoporosis activity is a new compound with piperazine-tetracycline in the steroid structure of estrone." | 3.70 | [The estrogenic activities of 2-[3-estrone-N-ethyl-piperazine-methyl]tetracycline(XW630)--a new compound with anti-osteoporosis activity]. ( Jiao, X; Mo, Z; Su, H; Weng, L; Zheng, H, 1998) |
| " This loss, combined with the low plasma concentrations of androstenedione, dehydroepiandrosterone, and testosterone (and low concentrations of oestrone of adrenal origin), indicates that adrenal androgens may be essential for the maintenance of bone mass in postmenopausal women with Addison's disease." | 3.67 | Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass. ( Crabbé, J; Devogelaer, JP; Nagant de Deuxchaisnes, C, 1987) |
| " The results showed reduced levels of both estrogens in smokers as compared with nonsmokers in all three dosage groups." | 2.66 | Cigarette smoking, serum estrogens, and bone loss during hormone-replacement therapy early after menopause. ( Christiansen, C; Jensen, J; Rødbro, P, 1985) |
| "To explore the structural dependence of the oral potency and side effect of estrogen-RGD peptide conjugates, here six novel conjugates were prepared via introducing RGD-tetrapeptides into both 3- and 17-positions of estradiol, and introducing RGD-octapeptides into 3-position of estrone." | 1.35 | 3D QSAR of novel estrogen-RGD peptide conjugates: getting insight into structural dependence of anti-osteoporosis activity and side effect of estrogen in ERT. ( Li, C; Liu, J; Peng, L; Peng, S; Zhang, X; Zhao, M, 2009) |
| "Women in Group II (N = 37) with osteopenia had lower levels of E1G (P<0." | 1.34 | Age-related changes in bone turnover markers and ovarian hormones in premenopausal and postmenopausal Indian women. ( Bhanuprakash, KV; Desai, MP; Donde, UM; Khatkhatay, MI, 2007) |
| " The findings of this study show that piperazinyl estrone at dosage of 1 mg/kg/d is most efficacious in preventing the bone losses in aged rats and has no side effect on uterus." | 1.33 | [Piperazinyl estrone, a new estrogen derivant, prevents bone loss in aged rats]. ( Li, Q; Weng, L; Wu, X; Zheng, H, 2005) |
| " A preliminary dose-response study performed in weanling rats determined 2000 microg/kg/day to be the optimal dose of 16alpha-OHE(1) for studying estrogenic effect on bone." | 1.32 | Comparative effects of long-term continuous release of 16 alpha-hydroxyestrone and 17 beta-estradiol on bone, uterus, and serum cholesterol in ovariectomized adult rats. ( Kennedy, AM; Lotinun, S; Turner, RT; Westerlind, KC, 2003) |
| "The finding of this study shows that lower dosage of piperazinyl estrone has effect on preventing the bone losses in OVX rats, while the bone formation and the uterus are not affected, thus supporting the hypothesis that piperazinyl estrone has the potential to prevent postmenopausal bone loss in women with less side effects." | 1.32 | [Piperazinyl estrone prevents bone loss in ovariectomized rats]. ( Chen, HQ; Hu, B; Huang, LF; Li, QN; Weng, LL; Zheng, H, 2003) |
| "Sixty seven old females with senile osteoporosis were divided into 4 groups, Group 1 (n = 28, mean age; 74." | 1.28 | [The effect of estrogen and, sex-steroids and thyroid hormone preparation on bone mineral density in senile osteoporosis--a comparative study of the effect of 1 alpha-hydroxycholecalciferol (1 alpha-OHD3) on senile osteoporosis]. ( Orimo, H; Shiraki, M, 1991) |
| "60% of our patients showed increased bone resorption (PCA less than 55%); in these subjects testosterone and androstenedione plasma levels were significantly lower than in subjects not affected by osteoporosis." | 1.27 | Osteoporosis and decline of gonadal function in the elderly male. ( Foresta, C; Gribaldo, R; Guarneri, G; Mastrogiacomo, I; Meneghello, A; Mioni, R; Ruzza, G, 1984) |
| " Requisites of such therapy are a through history to establish a real need, a complete gynecologic examination with a Pap smear before therapy begins and annually afterward, use of the smallest daily dose of estrogen that gives the desired effect, and periodic attempts to reduce the dosage or stop the hormone." | 1.26 | Estrogens for the menopause. Maximizing benefits, minimizing risks. ( Seller, JC, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (61.70) | 18.7374 |
| 1990's | 6 (12.77) | 18.2507 |
| 2000's | 11 (23.40) | 29.6817 |
| 2010's | 1 (2.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, C | 2 |
| Cui, W | 1 |
| Zhao, M | 3 |
| Yang, J | 1 |
| Peng, S | 3 |
| Xiong, Y | 1 |
| Chang, HW | 1 |
| Liu, J | 1 |
| Zhang, X | 1 |
| Peng, L | 1 |
| Li, C | 1 |
| Lotinun, S | 1 |
| Westerlind, KC | 1 |
| Kennedy, AM | 1 |
| Turner, RT | 1 |
| Gruber, DM | 1 |
| Huber, JC | 1 |
| Williams, NI | 1 |
| Reed, JL | 1 |
| Leidy, HJ | 1 |
| Legro, RS | 1 |
| De Souza, MJ | 1 |
| Oncken, C | 1 |
| Prestwood, K | 1 |
| Cooney, JL | 1 |
| Unson, C | 1 |
| Fall, P | 1 |
| Kulldorff, M | 1 |
| Raisz, LG | 1 |
| Li, QN | 1 |
| Weng, LL | 1 |
| Huang, LF | 1 |
| Hu, B | 1 |
| Chen, HQ | 1 |
| Zheng, H | 3 |
| HOLLO, I | 1 |
| POLISHUK, Z | 1 |
| KLEINHAUSE, EM | 1 |
| Wu, X | 1 |
| Li, Q | 1 |
| Weng, L | 2 |
| Desai Meena, P | 1 |
| Khatkhatay, MI | 2 |
| Bhanu Prakash, KV | 1 |
| Savardekar, LS | 1 |
| Shah, RS | 1 |
| Ansari, Z | 1 |
| Desai, MP | 1 |
| Bhanuprakash, KV | 1 |
| Donde, UM | 1 |
| Brody, S | 1 |
| Carlström, K | 1 |
| Lagrelius, A | 2 |
| Lunell, NO | 1 |
| Rosenborg, L | 1 |
| Crilly, RG | 3 |
| Francis, RM | 1 |
| Nordin, BE | 5 |
| García, CR | 1 |
| Cutler, WB | 1 |
| Laufer, LR | 1 |
| Davidson, BJ | 3 |
| Ross, RK | 2 |
| Lagasse, LD | 1 |
| Siiteri, PK | 2 |
| Judd, HL | 3 |
| Foresta, C | 1 |
| Ruzza, G | 1 |
| Mioni, R | 1 |
| Guarneri, G | 1 |
| Gribaldo, R | 1 |
| Meneghello, A | 1 |
| Mastrogiacomo, I | 1 |
| Notelovitz, M | 1 |
| MacMahon, B | 1 |
| Trichopoulos, D | 1 |
| Cole, P | 1 |
| Brown, J | 1 |
| Paganini-Hill, A | 1 |
| Hammond, GD | 1 |
| Riggs, BL | 3 |
| Coulam, CB | 1 |
| Toft, DO | 1 |
| Smetnik, VP | 1 |
| Chapurlat, RD | 1 |
| Bauer, DC | 1 |
| Cummings, SR | 1 |
| Hui, SL | 2 |
| Perkins, AJ | 1 |
| Zhou, L | 1 |
| Longcope, C | 3 |
| Econs, MJ | 1 |
| Peacock, M | 1 |
| McClintock, C | 1 |
| Johnston, CC | 3 |
| Mo, Z | 1 |
| Jiao, X | 1 |
| Su, H | 1 |
| Manolagas, SC | 1 |
| Anderson, DC | 1 |
| Lindsay, R | 1 |
| Marshall, DH | 4 |
| Seller, JC | 1 |
| Crilly, R | 2 |
| Horsman, A | 1 |
| Cawood, M | 1 |
| Shiraki, M | 1 |
| Orimo, H | 1 |
| Eichner, JE | 1 |
| Friedrich, CA | 1 |
| Cauley, JA | 1 |
| Kamboh, MI | 1 |
| Gutai, JP | 1 |
| Kuller, LH | 1 |
| Ferrell, RE | 1 |
| Ohta, H | 1 |
| Suda, Y | 1 |
| Makita, K | 1 |
| Nozawa, S | 1 |
| Nemoto, K | 1 |
| Nilas, L | 1 |
| Christiansen, C | 3 |
| Reginster, JY | 1 |
| Deroisy, R | 1 |
| Albert, A | 1 |
| Denis, D | 1 |
| Lecart, MP | 1 |
| Collette, J | 1 |
| Franchimont, P | 1 |
| Devogelaer, JP | 1 |
| Crabbé, J | 1 |
| Nagant de Deuxchaisnes, C | 1 |
| Riis, BJ | 1 |
| Rødbro, P | 2 |
| Martin, RB | 1 |
| Butcher, RL | 1 |
| Sherwood, LL | 1 |
| Buckendahl, P | 1 |
| Boyd, RD | 1 |
| Farris, D | 1 |
| Sharkey, N | 1 |
| Dannucci, G | 1 |
| Slemenda, C | 1 |
| Wahner, HW | 2 |
| Melton, LJ | 1 |
| Richelson, LS | 1 |
| Offord, KP | 1 |
| Jensen, J | 1 |
| Ryan, RJ | 1 |
| Jiang, NS | 1 |
| Mattox, VR | 1 |
| Goldfarb, AF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Moderate Aerobic Exercise Combined With Caloric Restriction on Circulating Estrogens and IGF-I in Premenopausal Women[NCT05107804] | 47 participants (Actual) | Interventional | 2001-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for estrone and Osteoporosis
| Article | Year |
|---|---|
Conjugated estrogens--the natural SERMs.
Topics: 2-Methoxyestradiol; Anticarcinogenic Agents; Cardiovascular Diseases; Dihydrotestosterone; Equilin; | 1999 |
Steroid hormones, ageing and bone.
Topics: Adult; Aged; Aging; Androstenedione; Bone and Bones; Calcium; Castration; Dehydroepiandrosterone; Es | 1981 |
3 trials available for estrone and Osteoporosis
| Article | Year |
|---|---|
Estrogen and progesterone exposure is reduced in response to energy deficiency in women aged 25-40 years.
Topics: Adult; Body Composition; Breast Neoplasms; Caloric Restriction; Estradiol; Estrogens; Estrone; Exerc | 2010 |
Effects of smoking cessation or reduction on hormone profiles and bone turnover in postmenopausal women.
Topics: Dehydroepiandrosterone; Estradiol; Estrogen Replacement Therapy; Estrone; Female; Humans; Middle Age | 2002 |
Cigarette smoking, serum estrogens, and bone loss during hormone-replacement therapy early after menopause.
Topics: Adult; Bone Resorption; Drug Combinations; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; M | 1985 |
42 other studies available for estrone and Osteoporosis
| Article | Year |
|---|---|
Studies on the synthesis and anti-Osteoporosis of estrogen-GHRPs linkers.
Topics: Animals; Body Weight; Calcium; Cross-Linking Reagents; Estrogens; Femur; Growth Hormone-Releasing Ho | 2003 |
Improved anti-osteoporosis potency and reduced endometrial membrane hyperplasia during hormone replacement therapy with estrogen-RGD peptide conjugates.
Topics: Alkaline Phosphatase; Animals; Calcium; Endometrium; Estrogen Replacement Therapy; Estrogens; Female | 2007 |
3D QSAR of novel estrogen-RGD peptide conjugates: getting insight into structural dependence of anti-osteoporosis activity and side effect of estrogen in ERT.
Topics: Amino Acid Sequence; Animals; Bone and Bones; Computer Simulation; Estrogen Replacement Therapy; Est | 2009 |
Comparative effects of long-term continuous release of 16 alpha-hydroxyestrone and 17 beta-estradiol on bone, uterus, and serum cholesterol in ovariectomized adult rats.
Topics: Animals; Bone and Bones; Cholesterol; Delayed-Action Preparations; Estradiol; Estriol; Female; Hydro | 2003 |
[Piperazinyl estrone prevents bone loss in ovariectomized rats].
Topics: Animals; Atrophy; Bone Density; Estradiol Congeners; Estrone; Female; Organ Size; Osteogenesis; Oste | 2003 |
THERAPY OF OSTEOPOROSIS.
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Anabolic Agents; Androgens; Androsterone; Calcium, Die | 1963 |
Treatment of post-menopausal osteoporosis with estrone micro-crystal precipitates.
Topics: Estrogens; Estrone; Female; Humans; Osteoporosis; Osteoporosis, Postmenopausal | 1952 |
[Piperazinyl estrone, a new estrogen derivant, prevents bone loss in aged rats].
Topics: Aging; Animals; Estrone; Female; Osteogenesis; Osteoporosis; Rats; Rats, Sprague-Dawley; Uterus | 2005 |
Hormonal profiles and biochemical indices of bone turnover in Indian women.
Topics: Adult; Age Distribution; Aged; Amino Acids; Biomarkers; Bone and Bones; Collagen Type I; Databases, | 2007 |
Age-related changes in bone turnover markers and ovarian hormones in premenopausal and postmenopausal Indian women.
Topics: Adult; Aged; Aging; Biomarkers; Body Mass Index; Bone and Bones; Bone Density; Bone Diseases, Metabo | 2007 |
Adrenal steroids, bone mineral content and endometrial pathology in postmenopausal women.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Bone and Bones; Dehydroepiandrosterone; Dehydr | 1981 |
Treatment with oral estrone sulphate in the female climacteric. III. Effects on bone density and on certain biochemical parameters.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Climacteric; Estrogens, Conjugated (USP); Estrone; Fema | 1981 |
Preservation of the ovary: a reevaluation.
Topics: Adult; Age Factors; Androstenedione; Estrone; Female; Humans; Hysterectomy; Middle Aged; Osteoporosi | 1984 |
Physical characteristics and sex hormone levels in patients with osteoporotic hip fractures or endometrial cancer.
Topics: Aged; Androstenedione; Body Weight; Estradiol; Estrone; Female; Gonadal Steroid Hormones; Hip Fractu | 1983 |
Osteoporosis and decline of gonadal function in the elderly male.
Topics: Aged; Androstenedione; Bone Resorption; Estradiol; Estrone; Humans; Male; Middle Aged; Osteoporosis; | 1984 |
When and how to use estrogen therapy in women over 60.
Topics: Aged; Atrophy; Cystitis; Dose-Response Relationship, Drug; Estradiol; Estradiol Congeners; Estrogens | 1980 |
Cigarette smoking and urinary estrogens.
Topics: Breast Neoplasms; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Menopause; Menstruation; M | 1982 |
Total and free estrogens and androgens in postmenopausal women with hip fractures.
Topics: Aged; Androgens; Androstenedione; Estradiol; Estrogens; Estrone; Female; Hip Fractures; Humans; Meno | 1982 |
Concentration of cytosolic estrogen receptors in patients with postmenopausal osteoporosis.
Topics: Aged; Androstenedione; Cervix Uteri; Cytosol; Estradiol; Estrone; Female; Gonadal Steroid Hormones; | 1980 |
[Principles of replacement hormone therapy in climacteric disorders].
Topics: Adult; Aged; Cardiovascular Diseases; Climacteric; Estradiol; Estriol; Estrogen Replacement Therapy; | 1995 |
Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: study of osteoporotic fractures.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Biomarkers; Bone Resorption; Collagen; Collagen Type | 2001 |
Bone loss at the femoral neck in premenopausal white women: effects of weight change and sex-hormone levels.
Topics: Adult; Body Weight; Bone Density; Cohort Studies; Estradiol; Estrone; Female; Femur Neck; Follicle S | 2002 |
[The estrogenic activities of 2-[3-estrone-N-ethyl-piperazine-methyl]tetracycline(XW630)--a new compound with anti-osteoporosis activity].
Topics: Animals; Binding, Competitive; Estradiol; Estrogens; Estrone; Female; Humans; Mice; Osteoporosis; Pi | 1998 |
Adrenal steroids and the development of osteoporosis in oophorectomised women.
Topics: 17-Ketosteroids; Adult; Androgens; Androstenediols; Androstenedione; Castration; Dehydroepiandroster | 1979 |
Metabolic effects of corticosteroid therapy in post-menopausal women.
Topics: Androstenedione; Bone and Bones; Calcium; Creatinine; Dehydroepiandrosterone; Estradiol; Estrone; Fe | 1979 |
Estrogens for the menopause. Maximizing benefits, minimizing risks.
Topics: Affective Symptoms; Arteriosclerosis; Breast Neoplasms; Climacteric; Cystitis; Estradiol; Estrogens; | 1977 |
Prevalence, pathogenesis and treatment of post-menopausal osteoporosis.
Topics: Aged; Androstenedione; Calcium; Ergocalciferols; Estradiol; Estrone; Ethinyl Estradiol; Female; Huma | 1979 |
Plasma androstenedione and oestrone levels in normal and osteoporotic postmenopausal women.
Topics: Adult; Aged; Androstenedione; Castration; Estrone; Female; Humans; Menopause; Middle Aged; Osteoporo | 1977 |
Hormonal status in normal, osteoporotic and corticosteroid-treated postmenopausal women.
Topics: Adrenal Cortex Hormones; Androstenedione; Creatinine; Estrone; Female; Humans; Hydroxyproline; Menop | 1978 |
[The effect of estrogen and, sex-steroids and thyroid hormone preparation on bone mineral density in senile osteoporosis--a comparative study of the effect of 1 alpha-hydroxycholecalciferol (1 alpha-OHD3) on senile osteoporosis].
Topics: Age Factors; Aged; Aged, 80 and over; Androstenediol; Androstenedione; Bone Density; Calcium; Drug C | 1991 |
Alpha 2-HS glycoprotein phenotypes and quantitative hormone and bone measures in postmenopausal women.
Topics: Aged; Alleles; alpha-Macroglobulins; Bone Density; Cohort Studies; Estradiol; Estrogens; Estrone; Fe | 1990 |
[Influences of menopause and oophorectomy on bone metabolism and spinal bone mineral content].
Topics: Alkaline Phosphatase; Androstenedione; Bone and Bones; Bone Density; Calcium; Estrone; Female; Human | 1991 |
The pathophysiology of peri- and postmenopausal bone loss.
Topics: Aged; Alkaline Phosphatase; Bone and Bones; Estradiol; Estrone; Female; Follicle Stimulating Hormone | 1989 |
Relationship between whole plasma calcitonin levels, calcitonin secretory capacity, and plasma levels of estrone in healthy women and postmenopausal osteoporotics.
Topics: Adult; Aged; Calcitonin; Estrone; Female; Humans; Menopause; Metabolic Clearance Rate; Middle Aged; | 1989 |
Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass.
Topics: Addison Disease; Adult; Aged; Androgens; Androstenedione; Bone and Bones; Dehydroepiandrosterone; Es | 1987 |
The role of serum concentrations of sex steroids and bone turnover in the development and occurrence of postmenopausal osteoporosis.
Topics: Aged; Androstenedione; Bone and Bones; Bone Resorption; Estradiol; Estrogens; Estrone; Female; Human | 1986 |
Androgen and estrogen dynamics in pre- and postmenopausal women: a comparison between smokers and nonsmokers.
Topics: Androgens; Androstenedione; Estradiol; Estrogens; Estrone; Female; Humans; Menopause; Middle Aged; O | 1988 |
Effects of ovariectomy in beagle dogs.
Topics: Animals; Bone and Bones; Calcium-Binding Proteins; Disease Models, Animal; Dogs; Estradiol; Estrogen | 1987 |
Sex steroids and bone mass. A study of changes about the time of menopause.
Topics: Adult; Bone and Bones; Calcium-Binding Proteins; Diet; Estradiol; Estrone; Female; Gonadal Steroid H | 1987 |
Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause.
Topics: Adult; Aged; Bone and Bones; Densitometry; Estradiol; Estrone; Female; Humans; Lumbar Vertebrae; Men | 1986 |
Serum concentrations of estrogen, testosterone, and gonadotropins in osteoporotic and nonosteoporotic postmenopausal women.
Topics: Climacteric; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; | 1973 |
The climacteric and some of its problems.
Topics: Adolescent; Adrenal Glands; Adult; Arteriosclerosis; Climacteric; Coronary Disease; Diethylstilbestr | 1969 |