estrone has been researched along with Hormone-Dependent Neoplasms in 65 studies
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Endocrine therapy is a key modality in the management of breast cancer, with current options for postmenopausal women including tamoxifen, aromatase inhibitors and fulvestrant." | 8.87 | Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer. ( Coombes, RC; Januszewski, A; Palmieri, C; Stanway, S, 2011) |
| " In the present review, we summarized the action of the 19-nor-progestin nomegestrol acetate (NOMAC) on the sulfatase, 17beta-HSD1 and sulfotransferase activities in the hormone-dependent MCF-7 and T47-D human breast cancer cell lines." | 8.82 | Effect of nomegestrol acetate on estrogen biosynthesis and transformation in MCF-7 and T47-D breast cancer cells. ( Chetrite, G; Meschi, S; Pasqualini, JR; Shields-Botella, J, 2005) |
| "To investigate whether suppression of plasma estradiol and estrone sulfate levels by the aromatase inhibitors (AIs) anastrozole and letrozole is related to body mass index (BMI) in postmenopausal women with early estrogen receptor (ER) -positive breast cancer." | 7.78 | Suppression of plasma estrogen levels by letrozole and anastrozole is related to body mass index in patients with breast cancer. ( A'Hern, RP; Dixon, JM; Dowsett, M; Folkerd, EJ; Renshaw, L, 2012) |
| "We measured serum levels of estrone (E1), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS), and sex hormone-binding globulin (SHBG) in 142 postmenopausal women aged 50 and over with primary breast cancer who had undergone surgical treatment, and investigated the heterogeneity in the relations of endogenous sex hormone levels to hormone receptor status, using the case-series study method." | 7.74 | Relation of serum levels of estrogen and dehydroepiandrosterone sulfate to hormone receptor status among postmenopausal women with breast cancer. ( Fujiya, T; Inoue, H; Kakugawa, Y; Minami, Y; Tateno, H, 2007) |
| "It has been suggested that alterations in estradiol (E(2)) metabolism, resulting in increased production of 16alpha-hydroxyestrone (16alpha-OHE(1)), is associated with an increased risk of breast cancer." | 7.71 | Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells. ( Gallo, MA; Klinge, CM; Lewis, JS; Thomas, T; Thomas, TJ, 2001) |
| "Using different hormone-dependent (MCF-7, T-47D) and hormone-independent (MDA-MB-231, Hs-578S, MDA-MB-436) human breast cancer cells, the interconversion estrone (E1)<-->estradiol (E2) was explored." | 7.69 | Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020). ( Chetrite, G; Nguyen, BL; Pasqualini, JR, 1995) |
| " Several lines of evidence indicate that the major source of estrogen in breast cancer cells may be from conversion of estrone sulfate to estrone by the enzyme estrone sulfatase." | 7.69 | Inhibition of placental estrone sulfatase activity and MCF-7 breast cancer cell proliferation by estrone-3-amino derivatives. ( Jagannathan, S; Li, PK; Rhodes, ME; Selcer, KW, 1996) |
| " The major source of estrogen in breast cancer cells may be the conversion of estrone sulfate to estrone by the enzyme estrone sulfatase." | 7.69 | Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines. ( Hegde, PV; Li, PK; Selcer, KW, 1997) |
| "In the present studies, the concentrations (mammary tissue and plasma) of estrone (E1), estradiol (E2) and their sulfates (E1S and E2S), as well as the sulfatase and aromatase activities, were evaluated in patients with breast fibroadenomas." | 7.69 | Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. ( Chetrite, G; Cortes-Prieto, J; Pasqualini, JR; Ruiz, A; Talbi, M, 1997) |
| "About one third of unselected postmenopausal women with advanced breast cancer respond to treatment with aminoglutethimide and hydrocortisone, but they all eventually relapse, and further progression of disease occurs." | 7.67 | Endocrine changes associated with relapse in advanced breast cancer patients on aminoglutethimide therapy. ( Dowsett, M; Harris, AL; Jeffcoate, SL; Smith, IE, 1984) |
| "For oestrone only, there was a significant effect of dose (on-treatment means: 0." | 6.67 | Endocrine changes with the aromatase inhibitor fadrozole hydrochloride in breast cancer. ( Coombes, RC; Dowsett, M; Moore, J; Powles, TJ; Rubens, R; Smith, IE; Smithers, D; Trunet, PF, 1994) |
| "Endocrine therapy is a key modality in the management of breast cancer, with current options for postmenopausal women including tamoxifen, aromatase inhibitors and fulvestrant." | 4.87 | Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer. ( Coombes, RC; Januszewski, A; Palmieri, C; Stanway, S, 2011) |
| " In the present review, we summarized the action of the 19-nor-progestin nomegestrol acetate (NOMAC) on the sulfatase, 17beta-HSD1 and sulfotransferase activities in the hormone-dependent MCF-7 and T47-D human breast cancer cell lines." | 4.82 | Effect of nomegestrol acetate on estrogen biosynthesis and transformation in MCF-7 and T47-D breast cancer cells. ( Chetrite, G; Meschi, S; Pasqualini, JR; Shields-Botella, J, 2005) |
| "To investigate whether suppression of plasma estradiol and estrone sulfate levels by the aromatase inhibitors (AIs) anastrozole and letrozole is related to body mass index (BMI) in postmenopausal women with early estrogen receptor (ER) -positive breast cancer." | 3.78 | Suppression of plasma estrogen levels by letrozole and anastrozole is related to body mass index in patients with breast cancer. ( A'Hern, RP; Dixon, JM; Dowsett, M; Folkerd, EJ; Renshaw, L, 2012) |
| "We measured serum levels of estrone (E1), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS), and sex hormone-binding globulin (SHBG) in 142 postmenopausal women aged 50 and over with primary breast cancer who had undergone surgical treatment, and investigated the heterogeneity in the relations of endogenous sex hormone levels to hormone receptor status, using the case-series study method." | 3.74 | Relation of serum levels of estrogen and dehydroepiandrosterone sulfate to hormone receptor status among postmenopausal women with breast cancer. ( Fujiya, T; Inoue, H; Kakugawa, Y; Minami, Y; Tateno, H, 2007) |
| "It has been suggested that alterations in estradiol (E(2)) metabolism, resulting in increased production of 16alpha-hydroxyestrone (16alpha-OHE(1)), is associated with an increased risk of breast cancer." | 3.71 | Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells. ( Gallo, MA; Klinge, CM; Lewis, JS; Thomas, T; Thomas, TJ, 2001) |
| "To determine the effects of aromatase inhibitors on oestrogen uptake, in situ aromatase activity and endogenous oestrogens in the breast, postmenopausal women with large primary ER-rich breast cancers have been treated neoadjuvantly for 3 months with either letrozole (2." | 3.71 | Local endocrine effects of aromatase inhibitors within the breast. ( Dixon, JM; Miller, WR, 2001) |
| "Using different hormone-dependent (MCF-7, T-47D) and hormone-independent (MDA-MB-231, Hs-578S, MDA-MB-436) human breast cancer cells, the interconversion estrone (E1)<-->estradiol (E2) was explored." | 3.69 | Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020). ( Chetrite, G; Nguyen, BL; Pasqualini, JR, 1995) |
| " Several lines of evidence indicate that the major source of estrogen in breast cancer cells may be from conversion of estrone sulfate to estrone by the enzyme estrone sulfatase." | 3.69 | Inhibition of placental estrone sulfatase activity and MCF-7 breast cancer cell proliferation by estrone-3-amino derivatives. ( Jagannathan, S; Li, PK; Rhodes, ME; Selcer, KW, 1996) |
| " The major source of estrogen in breast cancer cells may be the conversion of estrone sulfate to estrone by the enzyme estrone sulfatase." | 3.69 | Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines. ( Hegde, PV; Li, PK; Selcer, KW, 1997) |
| "In the present studies, the concentrations (mammary tissue and plasma) of estrone (E1), estradiol (E2) and their sulfates (E1S and E2S), as well as the sulfatase and aromatase activities, were evaluated in patients with breast fibroadenomas." | 3.69 | Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. ( Chetrite, G; Cortes-Prieto, J; Pasqualini, JR; Ruiz, A; Talbi, M, 1997) |
| "About one third of unselected postmenopausal women with advanced breast cancer respond to treatment with aminoglutethimide and hydrocortisone, but they all eventually relapse, and further progression of disease occurs." | 3.67 | Endocrine changes associated with relapse in advanced breast cancer patients on aminoglutethimide therapy. ( Dowsett, M; Harris, AL; Jeffcoate, SL; Smith, IE, 1984) |
| "Estrone sulfate (E1-S) is quantitatively the main estrogen in human breast cancer tissue." | 3.67 | [Cancer of the breast, mechanism of action of anti-estrogens]. ( Gelly, C; Pasqualini, JR, 1988) |
| "The concentrations of 17 beta-estradiol, progesterone, and estrone in leiomyomas and tumor-bearing myometrium were determined by specific radioimmunoassays in hysterectomy specimens from 12 women aged between 30 and 47 years." | 3.66 | Unconjugated steroids in leiomyomas and tumor-bearing myometrium. ( Besch, NF; Besch, PK; Buttram, VC; Otubu, JA, 1982) |
| " STX64 was administered orally (nine patients at 5 mg and five patients at 20 mg) as an initial dose followed 1 week later by 3 x 2 weekly cycles, with each cycle comprising daily dosing for 5 days followed by 9 days off treatment." | 2.72 | Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. ( Coombes, RC; Dobbs, N; Elliott, M; Kulinskaya, E; Potter, BV; Purohit, A; Reed, MJ; Stanczyk, FZ; Stanway, SJ; Sufi, S; Vigushin, D; Ward, R; Wilson, RH; Woo, LW, 2006) |
| "For oestrone only, there was a significant effect of dose (on-treatment means: 0." | 2.67 | Endocrine changes with the aromatase inhibitor fadrozole hydrochloride in breast cancer. ( Coombes, RC; Dowsett, M; Moore, J; Powles, TJ; Rubens, R; Smith, IE; Smithers, D; Trunet, PF, 1994) |
| "STS expression is increased in breast tumors and has prognostic significance." | 2.43 | Steroid sulfatase: molecular biology, regulation, and inhibition. ( Newman, SP; Potter, BV; Purohit, A; Reed, MJ; Woo, LW, 2005) |
| "One-third of the cases of breast cancer in postmenopausal women are hormone-dependent and the lesions regress upon treatment with antiestrogens or inhibition of estrogen biosynthesis." | 2.37 | Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways. ( Feil, PD; Leszczynski, D; Manni, A; Santen, RJ; Santner, SJ; Tilson-Mallet, N; Wright, C, 1986) |
| "We recruited 235 women with breast cancer who were prescribed AI therapy." | 1.42 | Association between self-report adherence measures and oestrogen suppression among breast cancer survivors on aromatase inhibitors. ( Brier, MJ; Chambless, D; DeMichele, A; Gross, R; Mao, JJ; Su, HI, 2015) |
| ") daily, and on day 35 the mice were dosed additionally with 20 mg/kg STX1040 s." | 1.35 | 17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer. ( Allan, GM; Chander, SK; Day, JM; Foster, PA; Lawrence, HR; Newman, SP; Parsons, MF; Potter, BV; Purohit, A; Reed, MJ; Tutill, HJ; Vicker, N, 2008) |
| "Many breast tumors are hormone-dependent, and estrogens, especially estradiol (E2), have a pivotal role in their growth and development." | 1.35 | Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core. ( Alho-Richmond, S; Huhtinen, K; Johansson, N; Karkola, S; Koskimies, P; Lilienkampf, A; Vihko, K; Wähälä, K, 2009) |
| "However, a "direct effect" of E(2) in breast cancerization has not yet been demonstrated." | 1.33 | Estradiol as an anti-aromatase agent in human breast cancer cells. ( Chetrite, GS; Pasqualini, JR, 2006) |
| "More than two-thirds of breast cancers occur in post-menopausal women, and depend on the estrogens for their proliferation and survival." | 1.32 | Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients. ( Akinaga, S; Ishida, H; Li, PK; Murakata, C; Nakata, T; Saeki, T; Sasano, H; Shiotsu, Y; Suzuki, T; Takashima, S, 2003) |
| "The presence of PSA in breast cancers is associated with the presence of steroid-hormone receptors and may be a favourable prognostic indicator." | 1.29 | Prostate-specific antigen in breast cyst fluid: possible role of prostate-specific antigen in hormone-dependent breast cancer. ( Erbas, H; Lai, LC; Lennard, TW; Peaston, RT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (36.92) | 18.7374 |
| 1990's | 16 (24.62) | 18.2507 |
| 2000's | 17 (26.15) | 29.6817 |
| 2010's | 8 (12.31) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hartmann, RW | 1 |
| Heindl, A | 1 |
| Schneider, MR | 1 |
| Schönenberger, H | 1 |
| von Angerer, E | 1 |
| Prekajac, J | 1 |
| Allan, GM | 2 |
| Lawrence, HR | 2 |
| Cornet, J | 1 |
| Bubert, C | 1 |
| Fischer, DS | 1 |
| Vicker, N | 2 |
| Smith, A | 1 |
| Tutill, HJ | 2 |
| Purohit, A | 6 |
| Day, JM | 2 |
| Mahon, MF | 2 |
| Reed, MJ | 6 |
| Potter, BV | 5 |
| Lilienkampf, A | 1 |
| Karkola, S | 1 |
| Alho-Richmond, S | 1 |
| Koskimies, P | 1 |
| Johansson, N | 1 |
| Huhtinen, K | 1 |
| Vihko, K | 1 |
| Wähälä, K | 2 |
| Fuhrman, BJ | 1 |
| Schairer, C | 1 |
| Gail, MH | 2 |
| Boyd-Morin, J | 1 |
| Xu, X | 1 |
| Sue, LY | 1 |
| Buys, SS | 1 |
| Isaacs, C | 1 |
| Keefer, LK | 1 |
| Veenstra, TD | 1 |
| Berg, CD | 1 |
| Hoover, RN | 2 |
| Ziegler, RG | 2 |
| Ursin, G | 1 |
| London, S | 1 |
| Stanczyk, FZ | 3 |
| Gentzschein, E | 1 |
| Paganini-Hill, A | 1 |
| Ross, RK | 1 |
| Pike, MC | 1 |
| Rossi, SC | 1 |
| Fears, TR | 1 |
| Bradlow, HL | 1 |
| Adlercreutz, H | 1 |
| Sepkovic, D | 1 |
| Kiuru, P | 1 |
| Vaught, JB | 1 |
| Donaldson, JL | 1 |
| Falk, RT | 1 |
| Fillmore, CM | 1 |
| Siiteri, PK | 2 |
| Lu, LJ | 1 |
| Cree, M | 1 |
| Josyula, S | 1 |
| Nagamani, M | 1 |
| Grady, JJ | 1 |
| Anderson, KE | 1 |
| Lewis, JS | 1 |
| Thomas, TJ | 1 |
| Klinge, CM | 1 |
| Gallo, MA | 1 |
| Thomas, T | 1 |
| Abul-Hajj, YJ | 1 |
| Brier, MJ | 1 |
| Chambless, D | 1 |
| Gross, R | 1 |
| Su, HI | 1 |
| DeMichele, A | 1 |
| Mao, JJ | 1 |
| Lønning, PE | 2 |
| Helle, H | 2 |
| Duong, NK | 1 |
| Ekse, D | 1 |
| Aas, T | 1 |
| Geisler, J | 1 |
| Tong, da Y | 2 |
| Wen, XQ | 1 |
| Jin, Y | 2 |
| Liu, ZW | 2 |
| Sun, HY | 2 |
| Zhou, FJ | 2 |
| Wu, XY | 2 |
| Palmieri, C | 1 |
| Januszewski, A | 1 |
| Stanway, S | 1 |
| Coombes, RC | 3 |
| Hong, Y | 1 |
| Rashid, R | 1 |
| Chen, S | 1 |
| Haynes, BP | 1 |
| Straume, AH | 1 |
| Dunbier, A | 1 |
| Knappskog, S | 1 |
| Dowsett, M | 4 |
| Folkerd, EJ | 1 |
| Dixon, JM | 3 |
| Renshaw, L | 1 |
| A'Hern, RP | 1 |
| Miller, WR | 2 |
| Stuart, M | 1 |
| Sahmoud, T | 1 |
| Nakata, T | 1 |
| Takashima, S | 1 |
| Shiotsu, Y | 1 |
| Murakata, C | 1 |
| Ishida, H | 1 |
| Akinaga, S | 1 |
| Li, PK | 3 |
| Sasano, H | 1 |
| Suzuki, T | 1 |
| Saeki, T | 1 |
| EDELSTEIN, H | 1 |
| Woo, LW | 2 |
| Newman, SP | 2 |
| Shields-Botella, J | 1 |
| Chetrite, G | 3 |
| Meschi, S | 1 |
| Pasqualini, JR | 9 |
| Chetrite, GS | 2 |
| Stanway, SJ | 1 |
| Sufi, S | 1 |
| Vigushin, D | 1 |
| Ward, R | 1 |
| Wilson, RH | 1 |
| Dobbs, N | 1 |
| Kulinskaya, E | 1 |
| Elliott, M | 1 |
| Kakugawa, Y | 1 |
| Minami, Y | 1 |
| Tateno, H | 1 |
| Inoue, H | 1 |
| Fujiya, T | 1 |
| Foster, PA | 1 |
| Parsons, MF | 1 |
| Chander, SK | 1 |
| Brozic, P | 1 |
| Lanisnik Risner, T | 1 |
| Gobec, S | 1 |
| Harris, AL | 1 |
| Smith, IE | 2 |
| Jeffcoate, SL | 1 |
| Percy, DH | 1 |
| Morris, VL | 1 |
| MacInnes, JI | 1 |
| Ip, C | 1 |
| Ip, MM | 1 |
| Pewnim, T | 2 |
| Adams, JB | 2 |
| Ho, KP | 1 |
| Sluyser, M | 3 |
| De Goeij, CC | 2 |
| Evers, SG | 2 |
| Otubu, JA | 1 |
| Buttram, VC | 1 |
| Besch, NF | 1 |
| Besch, PK | 1 |
| van der Valk, M | 1 |
| van Blitterswijk, WJ | 1 |
| Nguyen, BL | 2 |
| Li, S | 1 |
| Lévesque, C | 1 |
| Geng, CS | 1 |
| Yan, X | 1 |
| Labrie, F | 1 |
| Smithers, D | 1 |
| Moore, J | 1 |
| Trunet, PF | 1 |
| Powles, TJ | 1 |
| Rubens, R | 1 |
| Lai, LC | 1 |
| Erbas, H | 1 |
| Lennard, TW | 1 |
| Peaston, RT | 1 |
| Selcer, KW | 2 |
| Jagannathan, S | 1 |
| Rhodes, ME | 1 |
| Hegde, PV | 1 |
| Cortes-Prieto, J | 1 |
| Talbi, M | 1 |
| Ruiz, A | 1 |
| Singh, A | 1 |
| Ebert, C | 1 |
| Wright, F | 1 |
| Philippe, JC | 1 |
| Hejaz, HA | 1 |
| Probst-Hensch, NM | 1 |
| Ingles, SA | 1 |
| Diep, AT | 1 |
| Haile, RW | 1 |
| Kolonel, LN | 1 |
| Henderson, BE | 1 |
| Mu, YM | 1 |
| Yanase, T | 1 |
| Nishi, Y | 1 |
| Hirase, N | 1 |
| Goto, K | 1 |
| Takayanagi, R | 1 |
| Nawata, H | 1 |
| Grande, M | 1 |
| Carlström, K | 1 |
| Stege, R | 1 |
| Pousette, A | 1 |
| Faxén, M | 1 |
| Brodie, AM | 1 |
| Marsh, D | 1 |
| Brodie, HJ | 1 |
| Hähnel, R | 2 |
| Martin, JD | 2 |
| Masters, AM | 2 |
| Ratajczak, T | 2 |
| Twaddle, E | 2 |
| Chandra, DP | 1 |
| Archibald, L | 1 |
| Foo, MS | 1 |
| Saez, S | 1 |
| Martin, PM | 1 |
| Chouvet, CD | 1 |
| Varin, C | 1 |
| Moncharmont, B | 1 |
| Ramp, G | 1 |
| Pommier, RF | 1 |
| Woltering, EA | 1 |
| Keenan, EJ | 1 |
| Fletcher, WS | 1 |
| Shultz, TD | 1 |
| Wilcox, RB | 1 |
| Spuehler, JM | 1 |
| Howie, BJ | 1 |
| Gelly, C | 1 |
| Abraham, S | 1 |
| Briand, P | 1 |
| Hansen, FN | 1 |
| Santen, RJ | 1 |
| Leszczynski, D | 1 |
| Tilson-Mallet, N | 1 |
| Feil, PD | 1 |
| Wright, C | 1 |
| Manni, A | 1 |
| Santner, SJ | 1 |
| Morozova, TM | 1 |
| Mitina, RL | 1 |
| Ozhogina, ZB | 1 |
| Sidorkina, OM | 1 |
10 reviews available for estrone and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase II a | 2011 |
Recent data on intratumor estrogens in breast cancer.
Topics: Aromatase; Breast; Breast Neoplasms; Estradiol; Estrogens; Estrone; Female; Humans; Neoplasms, Hormo | 2011 |
Steroid sulfatase: molecular biology, regulation, and inhibition.
Topics: Animals; Breast Neoplasms; Clinical Trials, Phase I as Topic; Coumarins; Enzyme Inhibitors; Estrone; | 2005 |
Effect of nomegestrol acetate on estrogen biosynthesis and transformation in MCF-7 and T47-D breast cancer cells.
Topics: 17-Hydroxysteroid Dehydrogenases; Aromatase; Biotransformation; Breast Neoplasms; Cell Line, Tumor; | 2005 |
Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Topics: 17-Hydroxysteroid Dehydrogenases; Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogens; Estrone | 2008 |
Role, control and expression of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase activities in human breast cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Breast Neoplasms; Estradiol; Estrone; Female; Humans; Neoplasms, H | 1997 |
Regulation of steroid sulphatase and oestradiol 17 beta-hydroxysteroid dehydrogenase in breast cancer.
Topics: Arylsulfatases; Breast Neoplasms; Enzyme Inhibitors; Estradiol Dehydrogenases; Estrogens; Estrone; F | 1999 |
Steroid hormones and endometrial cancer.
Topics: Adenocarcinoma; Cell Nucleus; Cytosol; Estradiol Congeners; Estrogens; Estrone; Female; Humans; Neop | 1978 |
Estrogen receptors and blood hormone levels in endometrial carcinoma.
Topics: Adult; Aged; DNA, Neoplasm; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Hormones; Huma | 1979 |
Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aminoglutethimide; Androstenedione; Animals; Aromat | 1986 |
3 trials available for estrone and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Anastrozole ('Arimidex') blocks oestrogen synthesis both peripherally and within the breast in postmenopausal women with large operable breast cancer.
Topics: Aged; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors | 2002 |
Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Androstenediol; Breast Neoplasms; Coumarins; D | 2006 |
Endocrine changes with the aromatase inhibitor fadrozole hydrochloride in breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Dose-Response Relationship, | 1994 |
52 other studies available for estrone and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Binding, Competitive; Cattle; Estr | 1986 |
Benzo[a]carbazole derivatives. Synthesis, estrogen receptor binding affinities, and mammary tumor inhibiting activity.
Topics: Animals; Antineoplastic Agents; Carbazoles; Cattle; Cell Line; Estrogen Antagonists; Estrogens, Non- | 1986 |
Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Topics: 17-Hydroxysteroid Dehydrogenases; Amides; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; | 2006 |
Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core.
Topics: 17-Hydroxysteroid Dehydrogenases; Antineoplastic Agents; Azepines; Breast Neoplasms; Cell Line, Tumo | 2009 |
Estrogen metabolism and risk of breast cancer in postmenopausal women.
Topics: Aged; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Chromatography, Liquid; Confounding | 2012 |
A pilot study of urinary estrogen metabolites (16alpha-OHE1 and 2-OHE1) in postmenopausal women with and without breast cancer.
Topics: Breast Neoplasms; Case-Control Studies; Estradiol; Estriol; Estrone; Female; Humans; Hydroxyestrones | 1997 |
Quantifying estrogen metabolism: an evaluation of the reproducibility and validity of enzyme immunoassays for 2-hydroxyestrone and 16alpha-hydroxyestrone in urine.
Topics: Adult; Biomarkers; Breast Neoplasms; Estrogens; Evaluation Studies as Topic; Female; Follicular Phas | 1997 |
Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones.
Topics: Adult; Breast Neoplasms; Diet; Female; Glycine max; Humans; Hydroxyestrones; Isoflavones; Neoplasms, | 2000 |
Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-D | 2001 |
Effect of catechol estrogens on rat mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Estradiol; Estriol; Estrone; Female; Hydroxyestrones; Mam | 1979 |
Association between self-report adherence measures and oestrogen suppression among breast cancer survivors on aromatase inhibitors.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, T | 2015 |
Tissue estradiol is selectively elevated in receptor positive breast cancers while tumour estrone is reduced independent of receptor status.
Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Estradiol; Estrone; Female; Humans; Menopa | 2009 |
Changes of androgen receptor and insulin-like growth factor-1 in LNCaP prostate cancer cells treated with sex hormones and flutamide.
Topics: Androgen Antagonists; Androgens; Blotting, Western; Cell Line, Tumor; Dihydrotestosterone; Estrogens | 2010 |
Binding features of steroidal and nonsteroidal inhibitors.
Topics: Amino Acids; Androgens; Androstadienes; Androstenedione; Aromatase; Aromatase Inhibitors; Binding Si | 2011 |
Suppression of plasma estrogen levels by letrozole and anastrozole is related to body mass index in patients with breast cancer.
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Body Ma | 2012 |
Expression changes and regulation of AR and IGF-1 in PC3 prostate cancer cells treated with sexual hormones and flutamide.
Topics: Androgen Antagonists; Androgens; Blotting, Western; Dihydrotestosterone; Estrogens; Estrone; Flutami | 2012 |
Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; Enzyme Inhibitors | 2003 |
[The hormone estrone in the treatment of chronic postmenopausal non-inflammatory rheumatism].
Topics: Arthritis, Rheumatoid; Estrone; Humans; Neoplasms, Hormone-Dependent; Postmenopause; Rheumatic Disea | 1950 |
Estradiol as an anti-aromatase agent in human breast cancer cells.
Topics: Aromatase; Aromatase Inhibitors; Breast Neoplasms; Chromatography, Thin Layer; DNA, Complementary; E | 2006 |
Relation of serum levels of estrogen and dehydroepiandrosterone sulfate to hormone receptor status among postmenopausal women with breast cancer.
Topics: Aged; Aged, 80 and over; Breast Neoplasms; Case-Control Studies; Dehydroepiandrosterone Sulfate; Est | 2007 |
17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell L | 2008 |
Endocrine changes associated with relapse in advanced breast cancer patients on aminoglutethimide therapy.
Topics: Aminoglutethimide; Androstenedione; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estrone; Fe | 1984 |
Comparison of biologic behavior and histology of transplanted mammary tumors in GR mice.
Topics: Adenocarcinoma; Animals; Castration; Cell Differentiation; DNA, Viral; Estrone; Gammaretrovirus; Mal | 1982 |
Serum estrogens and estrogen responsiveness in 7,12-dimethylbenz[a]anthracene-induced mammary tumors as influenced by dietary fat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Castration; Dietary Fats; Estradiol; Estrogens; Estrone; | 1981 |
A relationship between estrogen sulfurylation and estrogen and progesterone receptor status in human mammary carcinoma.
Topics: Adult; Aged; Breast Neoplasms; Cytosol; Estrogens; Estrone; Female; Humans; Middle Aged; Neoplasms, | 1980 |
Changes in sensitivity to cyclophosphamide of mouse mammary tumors during serial transplantation.
Topics: Animals; Cell Division; Cyclophosphamide; Estrone; Female; Male; Mammary Neoplasms, Experimental; Mi | 1981 |
Unconjugated steroids in leiomyomas and tumor-bearing myometrium.
Topics: Adult; Estradiol; Estrone; Female; Gonadal Steroid Hormones; Humans; Leiomyoma; Menstruation; Middle | 1982 |
Changes in concanavalin A-mediated agglutination of hormone-dependent mouse mammary tumour cells during serial transplantation.
Topics: Agglutination; Animals; Concanavalin A; Dose-Response Relationship, Immunologic; Estrone; Female; Ma | 1980 |
Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020).
Topics: 17-Hydroxysteroid Dehydrogenases; Biotransformation; Breast Neoplasms; Danazol; Estradiol; Estrogen | 1995 |
Inhibitory effects of medroxyprogesterone acetate (MPA) and the pure antiestrogen EM-219 on estrone (E1)-stimulated growth of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat.
Topics: 17-Hydroxysteroid Dehydrogenases; 9,10-Dimethyl-1,2-benzanthracene; Adrenal Glands; Animals; Antineo | 1995 |
Prostate-specific antigen in breast cyst fluid: possible role of prostate-specific antigen in hormone-dependent breast cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Adenocarcinoma; Body Fluids; Breast Neoplasms; Cell Division; Cell | 1996 |
Inhibition of placental estrone sulfatase activity and MCF-7 breast cancer cell proliferation by estrone-3-amino derivatives.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Danazol; Dose-Response Relationship, Drug; Enzyme I | 1996 |
Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines.
Topics: Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Estrogens; Estrone; Humans; Neopl | 1997 |
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma.
Topics: Adolescent; Adult; Aromatase; Breast Neoplasms; Estradiol; Estrone; Fibroadenoma; Humans; Neoplasms, | 1997 |
Effect of Medrogestone on 17beta-hydroxysteroid dehydrogenase activity in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.
Topics: 17-Hydroxysteroid Dehydrogenases; Antineoplastic Agents, Hormonal; Breast Neoplasms; Dose-Response R | 1999 |
Synthesis and biological activity of the superestrogen (E)-17-oximino-3-O-sulfamoyl-1,3,5(10)-estratriene: x-ray crystal structure of (E)-17-oximino-3-hydroxy-1,3,5(10)-estratriene.
Topics: Animals; Antineoplastic Agents; Arylsulfatases; Breast Neoplasms; Crystallography, X-Ray; Drug Scree | 1999 |
Aromatase and breast cancer susceptibility.
Topics: Aged; Androstenedione; Aromatase; Breast Neoplasms; Disease Susceptibility; Estrogens; Estrone; Ethn | 1999 |
A nuclear receptor system constituted by RAR and RXR induces aromatase activity in MCF-7 human breast cancer cells.
Topics: Aromatase; Base Sequence; Benzoates; Breast Neoplasms; DNA Primers; Enzyme Induction; Estrone; Exons | 2000 |
Local endocrine effects of aromatase inhibitors within the breast.
Topics: Anastrozole; Androstadienes; Aromatase; Aromatase Inhibitors; Breast; Breast Neoplasms; Cells, Cultu | 2001 |
Estrogens affect endothelin-1 mRNA expression in LNCaP human prostate carcinoma cells.
Topics: Biomarkers, Tumor; Endothelin-1; Estradiol; Estrogen Receptor beta; Estrone; Gene Expression; Humans | 2002 |
Aromatase inhibitors--IV. Regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenedione; Animals; Aromatase Inhibitors; Estradiol; Estrone | 1979 |
A correlation between estrogen sulfotransferase levels and estrogen receptor status in human primary breast carcinoma.
Topics: Breast Neoplasms; Cytosol; Estrogens; Estrone; Female; Humans; Neoplasms, Hormone-Dependent; Phospho | 1979 |
Estrogen receptors and blood hormone levels in cervical carcinoma and other gynecological tumors.
Topics: Adult; Aged; DNA, Neoplasm; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Genital Neopla | 1979 |
Estradiol and progesterone receptor levels in human breast adenocarcinoma in relation to plasma estrogen and progesterone levels.
Topics: Adenocarcinoma; Breast Neoplasms; Estradiol; Estrogens; Estrone; Female; Humans; Menopause; Menstrua | 1978 |
Effect of the progestagen R5020 (promegestone) and of progesterone on the uptake and on the transformation of estrone sulfate in the MCF-7 and T-47d human mammary cancer cells: correlation with progesterone receptor levels.
Topics: Biotransformation; Breast Neoplasms; Estradiol; Estrone; Female; Humans; Neoplasms, Hormone-Dependen | 1992 |
Steroid sulphotransferase activity in human hormone-independent MDA-MB-468 mammary cancer cells.
Topics: Animals; Cell Division; Estradiol; Estriol; Estrogens; Estrone; Humans; Mammary Neoplasms, Experimen | 1992 |
Hormonal regulation of mouse mammary tumor growth.
Topics: Animals; DNA, Viral; Estrone; Female; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; M | 1987 |
The mechanism of hormone-sensitive breast cancer progression on antiestrogen therapy. Implications for treatment and protocol planning.
Topics: Adrenal Glands; Adrenalectomy; Adult; Aged; Breast Neoplasms; Castration; Dehydroepiandrosterone; Es | 1987 |
Dietary and hormonal interrelationships in premenopausal women: evidence for a relationship between dietary nutrients and plasma prolactin levels.
Topics: Adult; Breast Neoplasms; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diet, Vegetarian; D | 1987 |
[Cancer of the breast, mechanism of action of anti-estrogens].
Topics: Breast Neoplasms; Cell Line, Transformed; Estradiol; Estrone; Neoplasms, Hormone-Dependent; Polyunsa | 1988 |
Lipid metabolism and enzyme activities in hormone-dependent and hormone-independent mammary adenocarcinoma in GR mice.
Topics: Adenocarcinoma; Animals; Carbon Dioxide; Estrone; Fatty Acid Synthases; Fatty Acids; Female; Glucose | 1986 |
[Activation of protein kinase C and cAMP-dependent protein kinase in hormone-dependent mammary gland tumors during stimulation of their growth with progesterone and estrone].
Topics: Animals; Enzyme Activation; Estrone; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Str | 1986 |