Page last updated: 2024-11-07

estrone and Glioblastoma

estrone has been researched along with Glioblastoma in 2 studies

Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.

Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.

Research Excerpts

ExcerptRelevanceReference
"Estramustine is an estradiol-based agent that has been shown to accumulate in human glioma cells, resulting in a concentration-dependent alteration in cell size and shape within minutes and an inhibition of proliferation over 3 to 6 days."5.29Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells. ( Chen, Z; Keefe, DL; Lin, TT; Naftolin, F; Piepmeier, JM; Weinstein, MA; Yoshida, D; Zielinski, J, 1993)
"Glioblastoma multiforme is an aggressive form of human astrocytoma, with poor prognosis due to multi-drug resistance to a number of anticancer drugs."1.40Characterization of a multiple endogenously expressed adenosine triphosphate-binding cassette transporters using nuclear and cellular membrane affinity chromatography columns. ( Habicht, KL; Khadeer, MA; Moaddel, R; Shimmo, R; Singh, NS; Wainer, IW, 2014)
"Estramustine is an estradiol-based agent that has been shown to accumulate in human glioma cells, resulting in a concentration-dependent alteration in cell size and shape within minutes and an inhibition of proliferation over 3 to 6 days."1.29Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells. ( Chen, Z; Keefe, DL; Lin, TT; Naftolin, F; Piepmeier, JM; Weinstein, MA; Yoshida, D; Zielinski, J, 1993)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Habicht, KL1
Singh, NS1
Khadeer, MA1
Shimmo, R1
Wainer, IW1
Moaddel, R1
Piepmeier, JM1
Keefe, DL1
Weinstein, MA1
Yoshida, D1
Zielinski, J1
Lin, TT1
Chen, Z1
Naftolin, F1

Other Studies

2 other studies available for estrone and Glioblastoma

ArticleYear
Characterization of a multiple endogenously expressed adenosine triphosphate-binding cassette transporters using nuclear and cellular membrane affinity chromatography columns.
    Journal of chromatography. A, 2014, Apr-25, Volume: 1339

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily

2014
Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells.
    Neurosurgery, 1993, Volume: 32, Issue:3

    Topics: Brain Neoplasms; Cell Division; Cell Line; DNA Replication; Dose-Response Relationship, Drug; Estram

1993