estrone has been researched along with Glioblastoma in 2 studies
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Estramustine is an estradiol-based agent that has been shown to accumulate in human glioma cells, resulting in a concentration-dependent alteration in cell size and shape within minutes and an inhibition of proliferation over 3 to 6 days." | 5.29 | Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells. ( Chen, Z; Keefe, DL; Lin, TT; Naftolin, F; Piepmeier, JM; Weinstein, MA; Yoshida, D; Zielinski, J, 1993) |
| "Glioblastoma multiforme is an aggressive form of human astrocytoma, with poor prognosis due to multi-drug resistance to a number of anticancer drugs." | 1.40 | Characterization of a multiple endogenously expressed adenosine triphosphate-binding cassette transporters using nuclear and cellular membrane affinity chromatography columns. ( Habicht, KL; Khadeer, MA; Moaddel, R; Shimmo, R; Singh, NS; Wainer, IW, 2014) |
| "Estramustine is an estradiol-based agent that has been shown to accumulate in human glioma cells, resulting in a concentration-dependent alteration in cell size and shape within minutes and an inhibition of proliferation over 3 to 6 days." | 1.29 | Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells. ( Chen, Z; Keefe, DL; Lin, TT; Naftolin, F; Piepmeier, JM; Weinstein, MA; Yoshida, D; Zielinski, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Habicht, KL | 1 |
| Singh, NS | 1 |
| Khadeer, MA | 1 |
| Shimmo, R | 1 |
| Wainer, IW | 1 |
| Moaddel, R | 1 |
| Piepmeier, JM | 1 |
| Keefe, DL | 1 |
| Weinstein, MA | 1 |
| Yoshida, D | 1 |
| Zielinski, J | 1 |
| Lin, TT | 1 |
| Chen, Z | 1 |
| Naftolin, F | 1 |
2 other studies available for estrone and Glioblastoma
| Article | Year |
|---|---|
Characterization of a multiple endogenously expressed adenosine triphosphate-binding cassette transporters using nuclear and cellular membrane affinity chromatography columns.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily | 2014 |
Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells.
Topics: Brain Neoplasms; Cell Division; Cell Line; DNA Replication; Dose-Response Relationship, Drug; Estram | 1993 |