estrone has been researched along with Genetic Predisposition in 14 studies
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been hypothesized that the ratio of urinary 2-hydroxyestrone to 16alpha-hydroxyestrone (2-OHE1/16alpha-OHE1 represents a biomarker for breast cancer risk; the lower the ratio the higher the risk." | 7.71 | Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women. ( Bernstein, L; Gentzschein, E; London, S; Pike, MC; Stanczyk, FZ; Tseng, CC; Ursin, G; Yang, D, 2002) |
| "E1Cs have been associated with breast cancer risk and may contribute to tumor progression since STS is expressed in breast cancer where its activity exceeds that of aromatase." | 5.46 | SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway. ( Barman, P; Batzler, A; Buzdar, AU; Carlson, EE; Dudenkov, TM; Goetz, MP; Ibrahim-Zada, I; Ingle, JN; Jenkins, GD; Kalari, KR; Kubo, M; Moreno-Aspita, A; Nakamura, Y; Northfelt, DW; Pietrzak, TL; Robson, ME; Wang, L; Weinshilboum, RM; Williard, CV, 2017) |
| "Estrone sulfate was statistically significantly associated with breast cancer risk among women with low (< 1." | 3.73 | Endogenous steroid hormone concentrations and risk of breast cancer: does the association vary by a woman's predicted breast cancer risk? ( Eliassen, AH; Hankinson, SE; Missmer, SA; Tworoger, SS, 2006) |
| "It has been hypothesized that the ratio of urinary 2-hydroxyestrone to 16alpha-hydroxyestrone (2-OHE1/16alpha-OHE1 represents a biomarker for breast cancer risk; the lower the ratio the higher the risk." | 3.71 | Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women. ( Bernstein, L; Gentzschein, E; London, S; Pike, MC; Stanczyk, FZ; Tseng, CC; Ursin, G; Yang, D, 2002) |
| "Women at elevated risk for breast cancer are motivated to reduce their risk." | 2.80 | Women In Steady Exercise Research (WISER) Sister: study design and methods. ( Adelman, J; Bryan, CJ; DiGiovanni, L; Domchek, S; Fenderson, D; Galantino, ML; Good, J; Grant, L; Hwang, WT; Kontos, D; Kurzer, MS; Morales, K; Salvatore, D; Schmitz, KH; Schnall, M; Stopfer, J; Sturgeon, K; Williams, NI; Wu, S, 2015) |
| "E1Cs have been associated with breast cancer risk and may contribute to tumor progression since STS is expressed in breast cancer where its activity exceeds that of aromatase." | 1.46 | SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway. ( Barman, P; Batzler, A; Buzdar, AU; Carlson, EE; Dudenkov, TM; Goetz, MP; Ibrahim-Zada, I; Ingle, JN; Jenkins, GD; Kalari, KR; Kubo, M; Moreno-Aspita, A; Nakamura, Y; Northfelt, DW; Pietrzak, TL; Robson, ME; Wang, L; Weinshilboum, RM; Williard, CV, 2017) |
| "Spontaneous pneumothorax is mostly sporadic but may also occur in families with genetic disorders, such as Birt-Hogg-Dubé syndrome, which is caused by mutations in the folliculin (FLCN) gene." | 1.35 | Novel mutations in the folliculin gene associated with spontaneous pneumothorax. ( Alkadhi, H; Berger, W; Fröhlich, BA; Mátyás, G; Russi, EW; Tuor, C; Zeitz, C, 2008) |
| "Associations of genotypes with breast cancer risk were evaluated in the case-control study and with hormone levels in the postmenopausal women using multiple linear regression with assay batch, body mass index, parity, peri- or postmenopausal status, and age band as covariates." | 1.32 | Polymorphisms associated with circulating sex hormone levels in postmenopausal women. ( Day, NE; Dowsett, M; Dunning, AM; Easton, DF; Folkerd, E; Healey, CS; Kelemen, L; Luben, RN; Novik, KL; Ogata, S; Pharoah, PD; Ponder, BA; Tee, L, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Ruan, X | 1 |
| Seeger, H | 1 |
| Wallwiener, D | 1 |
| Huober, J | 1 |
| Mueck, AO | 1 |
| Ursin, G | 1 |
| London, S | 1 |
| Yang, D | 1 |
| Tseng, CC | 1 |
| Pike, MC | 1 |
| Bernstein, L | 2 |
| Stanczyk, FZ | 2 |
| Gentzschein, E | 1 |
| Ingle, JN | 2 |
| Kalari, KR | 2 |
| Barman, P | 2 |
| Shepherd, LE | 1 |
| Ellis, MJ | 1 |
| Goss, PE | 1 |
| Buzdar, AU | 2 |
| Robson, ME | 2 |
| Cairns, J | 1 |
| Carlson, EE | 2 |
| Eyman Casey, A | 1 |
| Hoskin, TL | 1 |
| Goodnature, BA | 1 |
| Haddad, TC | 1 |
| Goetz, MP | 2 |
| Weinshilboum, RM | 2 |
| Wang, L | 2 |
| Dudenkov, TM | 1 |
| Kubo, M | 1 |
| Ibrahim-Zada, I | 1 |
| Batzler, A | 1 |
| Jenkins, GD | 1 |
| Pietrzak, TL | 1 |
| Northfelt, DW | 1 |
| Moreno-Aspita, A | 1 |
| Williard, CV | 1 |
| Nakamura, Y | 1 |
| Schmitz, KH | 1 |
| Williams, NI | 1 |
| Kontos, D | 1 |
| Kurzer, MS | 1 |
| Schnall, M | 1 |
| Domchek, S | 1 |
| Stopfer, J | 1 |
| Galantino, ML | 1 |
| Hwang, WT | 1 |
| Morales, K | 1 |
| Wu, S | 1 |
| DiGiovanni, L | 1 |
| Salvatore, D | 1 |
| Fenderson, D | 1 |
| Good, J | 1 |
| Sturgeon, K | 1 |
| Grant, L | 1 |
| Bryan, CJ | 1 |
| Adelman, J | 1 |
| Fröhlich, BA | 1 |
| Zeitz, C | 1 |
| Mátyás, G | 1 |
| Alkadhi, H | 1 |
| Tuor, C | 1 |
| Berger, W | 1 |
| Russi, EW | 1 |
| Terry, K | 1 |
| McGrath, M | 1 |
| Lee, IM | 1 |
| Buring, J | 1 |
| De Vivo, I | 1 |
| Johnson, N | 1 |
| Walker, K | 1 |
| Gibson, LJ | 1 |
| Orr, N | 1 |
| Folkerd, E | 2 |
| Haynes, B | 1 |
| Palles, C | 1 |
| Coupland, B | 1 |
| Schoemaker, M | 1 |
| Jones, M | 1 |
| Broderick, P | 1 |
| Sawyer, E | 1 |
| Kerin, M | 1 |
| Tomlinson, IP | 1 |
| Zvelebil, M | 1 |
| Chilcott-Burns, S | 1 |
| Tomczyk, K | 1 |
| Simpson, G | 1 |
| Williamson, J | 1 |
| Hillier, SG | 1 |
| Ross, G | 1 |
| Houlston, RS | 1 |
| Swerdlow, A | 1 |
| Ashworth, A | 1 |
| Dowsett, M | 2 |
| Peto, J | 1 |
| Dos Santos Silva, I | 1 |
| Fletcher, O | 1 |
| Nickerson, ML | 1 |
| Warren, MB | 1 |
| Toro, JR | 1 |
| Matrosova, V | 1 |
| Glenn, G | 1 |
| Turner, ML | 1 |
| Duray, P | 1 |
| Merino, M | 1 |
| Choyke, P | 1 |
| Pavlovich, CP | 1 |
| Sharma, N | 1 |
| Walther, M | 1 |
| Munroe, D | 1 |
| Hill, R | 1 |
| Maher, E | 1 |
| Greenberg, C | 1 |
| Lerman, MI | 1 |
| Linehan, WM | 1 |
| Zbar, B | 1 |
| Schmidt, LS | 1 |
| Dunning, AM | 1 |
| Healey, CS | 1 |
| Tee, L | 1 |
| Luben, RN | 1 |
| Novik, KL | 1 |
| Kelemen, L | 1 |
| Ogata, S | 1 |
| Pharoah, PD | 1 |
| Easton, DF | 1 |
| Day, NE | 1 |
| Ponder, BA | 1 |
| Dereure, O | 1 |
| Eliassen, AH | 1 |
| Missmer, SA | 1 |
| Tworoger, SS | 1 |
| Hankinson, SE | 1 |
| Fan, J | 1 |
| McKean-Cowdin, R | 1 |
| Li, AX | 1 |
| Ballard-Barbash, R | 1 |
| McTiernan, A | 1 |
| Baumgartner, R | 1 |
| Gilliland, F | 1 |
| Kim, EH | 1 |
| Jeong, SY | 1 |
| Kim, HJ | 1 |
| Kim, YC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence of Birt-Hogg-Dubé Syndrome Among Patients With (Hereditary) Spontaneous Pneumothorax[NCT02916992] | Phase 1 | 200 participants (Anticipated) | Interventional | 2016-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for estrone and Genetic Predisposition
| Article | Year |
|---|---|
Women In Steady Exercise Research (WISER) Sister: study design and methods.
Topics: Adiponectin; Adult; Breast; Breast Neoplasms; Estrone; Exercise Therapy; Female; Genes, BRCA1; Genes | 2015 |
CYP3A variation, premenopausal estrone levels, and breast cancer risk.
Topics: Adult; Age Factors; Androgens; Breast Neoplasms; Case-Control Studies; Cross-Sectional Studies; Cyto | 2012 |
12 other studies available for estrone and Genetic Predisposition
| Article | Year |
|---|---|
The ratio of the estradiol metabolites 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16-OHE1) may predict breast cancer risk in postmenopausal but not in premenopausal women: two case-control studies.
Topics: Adult; Biomarkers; Breast Neoplasms; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Estrad | 2015 |
Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women.
Topics: Adult; Biomarkers; Breast Neoplasms; Estradiol; Estriol; Estrogens; Estrone; Female; Genetic Predisp | 2002 |
Single-nucleotide polymorphism biomarkers of adjuvant anastrozole-induced estrogen suppression in early breast cancer.
Topics: Adult; Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Estrone; Female; Genetic Pred | 2021 |
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.
Topics: Adult; Aged; Breast Neoplasms; Estrone; Female; Genetic Predisposition to Disease; Genome-Wide Assoc | 2017 |
Novel mutations in the folliculin gene associated with spontaneous pneumothorax.
Topics: Adult; DNA Mutational Analysis; Estrone; Exons; Family Health; Female; Genetic Predisposition to Dis | 2008 |
Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk.
Topics: Adult; Alleles; Case-Control Studies; Cholesterol Side-Chain Cleavage Enzyme; Endometrial Neoplasms; | 2010 |
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome.
Topics: Amino Acid Sequence; Base Sequence; Chromosomes, Human, Pair 17; Conserved Sequence; DNA Mutational | 2002 |
Polymorphisms associated with circulating sex hormone levels in postmenopausal women.
Topics: 17-alpha-Hydroxyprogesterone; Aged; Androstenedione; Aromatase; Aryl Hydrocarbon Hydroxylases; Breas | 2004 |
[Mutations of tumor suppressor genes coding for folliculin in Birt Hogg Dube syndrome].
Topics: Estrone; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Humans; Mutation; Skin Diseases | 2005 |
Endogenous steroid hormone concentrations and risk of breast cancer: does the association vary by a woman's predicted breast cancer risk?
Topics: Adult; Breast Neoplasms; Case-Control Studies; Estradiol; Estrone; Female; Genetic Predisposition to | 2006 |
An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivors.
Topics: Black or African American; Breast Neoplasms; C-Reactive Protein; Cohort Studies; Estradiol; Estrone; | 2006 |
A case of Birt-Hogg-Dubé syndrome.
Topics: Adult; Biopsy; Diagnosis, Differential; DNA Mutational Analysis; Estrone; Exons; Female; Gene Deleti | 2008 |