Page last updated: 2024-11-07

estrone and Disorders of Sex Development

estrone has been researched along with Disorders of Sex Development in 41 studies

Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.

Disorders of Sex Development: In gonochoristic organisms, congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. Effects from exposure to abnormal levels of GONADAL HORMONES in the maternal environment, or disruption of the function of those hormones by ENDOCRINE DISRUPTORS are included.

Research Excerpts

ExcerptRelevanceReference
"We examined associations between urinary phthalate metabolite concentrations in early pregnancy and serum free testosterone (FT), TT, estrone (E1), and estradiol (E2) in 591 woman/infant dyads in The Infant Development and Environment Study; we also examined relationships between hormones and newborn genital outcomes using multiple regression models with covariate adjustment."3.85Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes. ( Barrett, E; Butts, S; Haaland, W; Nguyen, R; Sathyanarayana, S; Schwartz, SM; Swan, SH; Wang, C, 2017)
" In the view of previously described patients we can conclude that: 1) intensity of virilisation depends on both plasma testosterone and androstenedione levels; 2) importance of gynecomastia depends on plasma E2 but not E1 levels; 3) FSH levels are not correlated with circulating androgens or estrogens but presumably depends on importance of seminiferous tubules' lesions."3.66[Study of a new case of male pseudohermaphroditism due to 17-ketosteroid reductase deficiency (author's transl)]. ( Berthezène, F; Chevallier, M; Claustrat, B; de Peretti, E; Dubernard, JM; Forest, MG, 1979)
" At the single dosage administered, estrone and estradiol produced all females at a male-producing incubation temperature."1.29The relative effectiveness of androstenedione, testosterone, and estrone, precursors to estradiol, in sex reversal in the red-eared slider (Trachemys scripta), a turtle with temperature-dependent sex determination. ( Bergeron, JM; Cantú, AR; Crews, D; Rhen, T, 1995)
"Estriol treatment also resulted in cranially hypertrophied oviducts at all incubation temperatures in a dose-dependent manner, whereas animals treated with estradiol-17 beta and estrone had normal oviducts."1.29The relative effectiveness of estrone, estradiol-17 beta, and estriol in sex reversal in the red-eared slider (Trachemys scripta), a turtle with temperature-dependent sex determination. ( Cantú, AR; Crews, D; Rhen, T; Vohra, R, 1996)
"A 24 years old male with pseudohermaphroditism due to a deficiency in 17-ketosteroid reductase activity is described."1.2717-ketosteroid reductase deficiency in an adult patient without gynaecomastia but with female psychosexual orientation. ( Audí, L; Esmatjes, E; Martinez de Osaba, MJ; Martinez-Mora, J; Millán, M; Peig, M; Viguera, J; Vilardell, E, 1983)
"A 46 XY individual with male pseudohermaphroditism was investigated."1.25Clinical and endocrinologic characterization of a patients with the syndrome of incomplete testicular feminization. ( MacDonald, PC; Madden, JD; Walsh, PC; Wilson, JD, 1975)
"In 22 children with male pseudohermaphroditism, plasma concentrations of testosterone and dehydroandrosterone sulfate were measured before and after HCG stimulation."1.25Children with male pseudohermaphroditism: endocrine and metabolic studies. ( Bertrand, J; De Peretti, E; Frederich, A; Saez, JM, 1971)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199031 (75.61)18.7374
1990's4 (9.76)18.2507
2000's1 (2.44)29.6817
2010's5 (12.20)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sathyanarayana, S1
Butts, S1
Wang, C1
Barrett, E1
Nguyen, R1
Schwartz, SM1
Haaland, W1
Swan, SH1
Arlos, MJ1
Parker, WJ1
Bicudo, JR1
Law, P1
Hicks, KA1
Fuzzen, MLM1
Andrews, SA1
Servos, MR1
Hassell, K1
Pettigrove, V1
Beresford, N1
Jobling, S1
Kumar, A1
Vajda, AM1
Barber, LB1
Gray, JL1
Lopez, EM1
Bolden, AM1
Schoenfuss, HL1
Norris, DO1
Williams, RJ1
Churchley, JH1
Kanda, R1
Johnson, AC1
SHEARMAN, RP1
LEE, CW1
ILBERY, PL1
KASE, N1
MORRIS, JM1
JOSSO, N1
DE GROUCHY, J1
AUVERT, J1
NEZELOF, C1
JAYLE, MF1
MOULLEC, J1
FREZAL, J1
DE CASAUBON, A1
LAMY, M1
SHARMA, DC1
DORFMAN, RI1
SOUTHREN, AL1
Holbech, H1
Kinnberg, K1
Petersen, GI1
Jackson, P1
Hylland, K1
Norrgren, L1
Bjerregaard, P1
Millán, M1
Audí, L1
Martinez-Mora, J1
Martinez de Osaba, MJ1
Viguera, J1
Esmatjes, E1
Peig, M1
Vilardell, E1
Schweikert, HU2
Weissbach, L1
Leyendecker, G1
Schwinger, E1
Wartenberg, H1
Krück, F1
Crews, D3
Cantú, AR2
Bergeron, JM2
Rhen, T2
Vohra, R1
Kaiser, J1
Arnold, SF1
Tran, DQ1
Collins, BM1
Vonier, PM1
Toscano, WA1
McLachlan, JA1
Stanczyk, FZ2
Goebelsmann, U3
Nakamura, RM2
Berthezène, F1
Forest, MG1
de Peretti, E4
Chevallier, M1
Claustrat, B1
Dubernard, JM1
Hall, TD1
Paul, WL1
Gallegos, AJ1
Guizar, E1
Armendares, S1
Cortés-Gallegos, V1
Cervantes, C1
Bedolla, N1
Parra, A1
Savage, MO1
Chaussain, JL2
Evain, D1
Roger, M1
Canlorbe, P2
Job, JC2
Cadillon, E1
Bertrand, J3
Imperato-McGinley, J1
Peterson, RE1
Stoller, R1
Goodwin, WE1
Aiman, J1
Hemsell, DL2
MacDonald, PC5
Edman, CD1
Winters, AJ1
Porter, JC1
Wilson, J1
Milewich, L1
Wilson, JD4
Knorr, D2
Bidlingmaier, F2
Madden, JD2
Walsh, PC2
Saez, JM2
Morera, AM1
Givens, JR1
Wiser, WL1
Summitt, RL1
Kerber, IJ1
Andersen, RN1
Pittaway, DE1
Fish, SA1
Frederich, A1
Horton, R1
Mestman, JH1
Arce, JJ1
Nagata, Y1
Thorneycroft, IH1
Mishell, DR1
Schneider, G1
Bardin, CW1
Harrod, MJ2
Goldstein, JL2
Engelhardt, D1
Garnier, PE1
Scholler, R1
Toublanc, JE1
Breuer, J1
Breuer, H1
Lisboa, BP1
Akram, H1
Weniger, JP1
Colombo, L1
Del Conte, E1
Clemenze, P1
Wade, AP1
Wilkinson, GS1
Davis, JC1
Jeffcoate, TN1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy[NCT04288427]120 participants (Anticipated)Interventional2020-09-25Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for estrone and Disorders of Sex Development

ArticleYear
Gynaecomastia in male adolescents.
    Clinics in endocrinology and metabolism, 1975, Volume: 4, Issue:1

    Topics: Adolescent; Diagnosis, Differential; Disorders of Sex Development; Estradiol; Estrogens; Estrone; Fo

1975

Other Studies

40 other studies available for estrone and Disorders of Sex Development

ArticleYear
Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes.
    The Journal of clinical endocrinology and metabolism, 2017, 06-01, Volume: 102, Issue:6

    Topics: Adult; Chromatography, Liquid; Cryptorchidism; Disorders of Sex Development; Estradiol; Estrone; Fem

2017
Modeling the exposure of wild fish to endocrine active chemicals: Potential linkages of total estrogenicity to field-observed intersex.
    Water research, 2018, 08-01, Volume: 139

    Topics: Animals; Disorders of Sex Development; Endocrine Disruptors; Estradiol; Estrogens; Estrone; Ethinyl

2018
No evidence of exposure to environmental estrogens in two feral fish species sampled from the Yarra River, Australia: A comparison with Northern Hemisphere studies.
    Ecotoxicology and environmental safety, 2016, Volume: 131

    Topics: Animals; Asia; Australia; Carps; Cyprinidae; Disorders of Sex Development; Endocrine Disruptors; Env

2016
Demasculinization of male fish by wastewater treatment plant effluent.
    Aquatic toxicology (Amsterdam, Netherlands), 2011, Volume: 103, Issue:3-4

    Topics: Animals; Benzhydryl Compounds; Colorado; Disorders of Sex Development; Endocrine Disruptors; Environ

2011
Comparing predicted against measured steroid estrogen concentrations and the associated risk in two United Kingdom river catchments.
    Environmental toxicology and chemistry, 2012, Volume: 31, Issue:4

    Topics: Animals; Disorders of Sex Development; England; Estradiol; Estrogens; Estrone; Ethinyl Estradiol; Fi

2012
CLINICAL, HORMONAL AND CYTOGENETIC FINDINGS IN A TRUE HERMAPHRODITE.
    The Journal of obstetrics and gynaecology of the British Commonwealth, 1964, Volume: 71

    Topics: Androgens; Biopsy; Bone Marrow Examination; Chromosomes; Cytodiagnosis; Cytogenetic Analysis; Disord

1964
STEROID SYNTHESIS IN THE CRYPTORCHID TESTES OF THREE CASES OF THE "TESTICULAR FEMINIZATION" SYNDROME.
    American journal of obstetrics and gynecology, 1965, Jan-01, Volume: 91

    Topics: Androgen-Insensitivity Syndrome; Androgens; Cryptorchidism; Dehydroepiandrosterone; Disorders of Sex

1965
TRUE HERMAPHRODITISM WITH XX-XY MOSAICISM, PROBABLY DUE TO DOUBLE FERTILIZATION OF THE OVUM.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Blood Group Antigens; Chromosome Aberrations; Chromosome

1965
STEROID BIOSYNTHESIS IN VITRO BY FEMINIZING TESTES.
    Endocrinology, 1965, Volume: 76

    Topics: Adolescent; Androgen-Insensitivity Syndrome; Androgens; Carbon Isotopes; Chromatography; Disorders o

1965
Detection of endocrine disrupters: evaluation of a Fish Sexual Development Test (FSDT).
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2006, Volume: 144, Issue:1

    Topics: Animals; Biomarkers; Disorders of Sex Development; Endocrine Disruptors; Estradiol; Estriol; Estrone

2006
17-ketosteroid reductase deficiency in an adult patient without gynaecomastia but with female psychosexual orientation.
    Acta endocrinologica, 1983, Volume: 102, Issue:4

    Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Androstenedione; Castration; Dehydroepiandrosterone; Disord

1983
Clinical, endocrinological, and cytological characterization of two 46, XX males.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:4

    Topics: Adult; Androstenedione; Biopsy; Chorionic Gonadotropin; Dihydrotestosterone; Disorders of Sex Develo

1982
The relative effectiveness of androstenedione, testosterone, and estrone, precursors to estradiol, in sex reversal in the red-eared slider (Trachemys scripta), a turtle with temperature-dependent sex determination.
    General and comparative endocrinology, 1995, Volume: 100, Issue:1

    Topics: Androstenedione; Animals; Disorders of Sex Development; Dose-Response Relationship, Drug; Estradiol;

1995
The relative effectiveness of estrone, estradiol-17 beta, and estriol in sex reversal in the red-eared slider (Trachemys scripta), a turtle with temperature-dependent sex determination.
    General and comparative endocrinology, 1996, Volume: 102, Issue:3

    Topics: Animals; Disorders of Sex Development; Dose-Response Relationship, Drug; Estradiol; Estriol; Estrone

1996
Scientists angle for answers.
    Science (New York, N.Y.), 1996, Dec-13, Volume: 274, Issue:5294

    Topics: Animals; Disorders of Sex Development; Estradiol; Estrogens; Estrone; Ethinyl Estradiol; Female; Fis

1996
Synergistic responses of steroidal estrogens in vitro (yeast) and in vivo (turtles).
    Biochemical and biophysical research communications, 1997, Jun-18, Volume: 235, Issue:2

    Topics: Animals; beta-Galactosidase; Disorders of Sex Development; Drug Synergism; Estradiol; Estriol; Estro

1997
Further in vitro steroid metabolic studies of testicular 17beta-reduction deficiency.
    Journal of steroid biochemistry, 1978, Volume: 9, Issue:2

    Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Androstenediol; Androstenedione; Dehydroepiandrosterone; Di

1978
[Study of a new case of male pseudohermaphroditism due to 17-ketosteroid reductase deficiency (author's transl)].
    Annales d'endocrinologie, 1979, Volume: 40, Issue:6

    Topics: 17-Hydroxysteroid Dehydrogenases; Adolescent; Androstenedione; Disorders of Sex Development; Estradi

1979
In vitro steroid metabolic studies in testicular 17 beta-reduction deficiency.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 41, Issue:06

    Topics: Adult; Androstenedione; Dehydroepiandrosterone; Disorders of Sex Development; Estradiol; Estrone; Hu

1975
Familial true hermaphorodism in three siblings: plasma hormonal profile and in vitro steroid biosynthesis in gonadal structures.
    The Journal of clinical endocrinology and metabolism, 1976, Volume: 42, Issue:4

    Topics: Adolescent; Androstenedione; Child; Dehydroepiandrosterone; Disorders of Sex Development; Estradiol;

1976
Endocrine studies in male pseudohermaphroditism in childhood and adolescence.
    Clinical endocrinology, 1978, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Androstenedione; Child; Child, Preschool; Dehydroepiandrosterone; Dihydrotestoste

1978
[In vitro studies of testicular biosynthesis in 4 cases of male pseudohermaphrodism (MPH) due to testicular 17 ketoreductase defect (author's transl)].
    Annales d'endocrinologie, 1979, Volume: 40, Issue:6

    Topics: 17-Hydroxysteroid Dehydrogenases; Adolescent; Adult; Androstenediols; Androstenedione; Dehydroepiand

1979
Male pseudohermaphroditism secondary to 17 beta-hydroxysteroid dehydrogenase deficiency: gender role change with puberty.
    The Journal of clinical endocrinology and metabolism, 1979, Volume: 49, Issue:3

    Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Androstenedione; Disorders of Sex Development; Estradiol; E

1979
Production and origin of estrogen in two true hermaphrodites.
    American journal of obstetrics and gynecology, 1978, Oct-15, Volume: 132, Issue:4

    Topics: Adolescent; Adult; Androstenedione; Disorders of Sex Development; Estradiol; Estrone; Female; Follic

1978
Embryonic testicular regression. A clinical spectrum of XY agonadal individuals.
    Obstetrics and gynecology, 1977, Volume: 49, Issue:2

    Topics: Adolescent; Adult; Androstenedione; Disorders of Sex Development; Estrone; Female; Gynecomastia; Hum

1977
Aromatization of androstenedione by cultured human fibroblasts.
    The Journal of clinical endocrinology and metabolism, 1976, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Androgen-Insensitivity Syndrome; Androstenedione; Cells, Cultured; Child; Child,

1976
Clinical and endocrinologic characterization of a patients with the syndrome of incomplete testicular feminization.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 41, Issue:4

    Topics: Androstenedione; Disorders of Sex Development; Estradiol; Estrone; Female; Follicle Stimulating Horm

1975
Further in vivo studies in male pseudohermaphroditism with gynecomastia due to a testicular 17-ketosteroid reductase defect (compared to a case of testicular feminization).
    The Journal of clinical endocrinology and metabolism, 1972, Volume: 34, Issue:3

    Topics: 17-Ketosteroids; Adolescent; Adult; Androgen-Insensitivity Syndrome; Androsterone; Dehydroepiandrost

1972
Familial male pseudohermaphroditism without gynecomastia due to deficient testicular 17-ketosteroid reductase activity.
    The New England journal of medicine, 1974, Oct-31, Volume: 291, Issue:18

    Topics: 17-Ketosteroids; Adolescent; Androstenedione; Circadian Rhythm; Dehydroepiandrosterone; Dihydrotesto

1974
Children with male pseudohermaphroditism: endocrine and metabolic studies.
    Birth defects original article series, 1971, Volume: 7, Issue:6

    Topics: 17-Ketosteroids; Adolescent; Alcohol Oxidoreductases; Androgen-Insensitivity Syndrome; Androstenedio

1971
Male pseudohermaphroditism due to testicular 17 -hydroxysteroid dehydrogenase deficiency.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 36, Issue:5

    Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Androstenedione; Dexamethasone; Disorders of Sex Devel

1973
Defective testicular testosterone synthesis by the pseudohermaphrodite rat: an abnormality of 17 beta-hydroxysteroid dehydrogenase.
    Endocrinology, 1970, Volume: 87, Issue:5

    Topics: 17-Ketosteroids; Androstanes; Animals; Carbon Isotopes; Chromatography, Gas; Chromatography, Thin La

1970
Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias.
    The New England journal of medicine, 1974, Oct-31, Volume: 291, Issue:18

    Topics: Abdomen; Adolescent; Androstenedione; Child, Preschool; Culture Techniques; Dihydrotestosterone; Dis

1974
Reifenstein's syndrome, a 17beta-hydroxysteroid-oxydoreductase deficiency?
    Acta endocrinologica. Supplementum, 1973, Volume: 173

    Topics: Androstenedione; Child; Disorders of Sex Development; Estradiol; Estrone; Follicle Stimulating Hormo

1973
Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on the release of gonadotropins in hypophyso-gonadal disorders of children and adolescents. V. Agonadism.
    The Journal of clinical endocrinology and metabolism, 1974, Volume: 38, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Disorders of Sex Development; Estradiol; Estrone; Female; Folli

1974
[Studies on metabolism of steroid hormones in vertebrates. X. Metabolism of (4- 14C)estrone in liver slices of normal and of sex-converted African water frogs (Xenopus laevis)].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1972, Volume: 353, Issue:12

    Topics: Animals; Carbon Isotopes; Chromatography; Chromatography, Paper; Crosses, Genetic; Disorders of Sex

1972
Familial incomplete male pseudohermaphroditism, type 1. Evidence for androgen resistance and variable clinical manifestations in a family with the Reifenstein syndrome.
    The New England journal of medicine, 1974, May-16, Volume: 290, Issue:20

    Topics: Adolescent; Adult; Androgen-Insensitivity Syndrome; Androgens; Androstenedione; Child; Child, Presch

1974
[Secretion of estrone and estradiol by the feminized chick-embryo testis].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1967, Apr-03, Volume: 264, Issue:14

    Topics: Animals; Chick Embryo; Disorders of Sex Development; Estradiol; Estrone; Male; Testis

1967
Steroid biosynthesis in vitro by the gonads of Sparus auratus L. (Teleostei) at different stages during natural sex reversal.
    General and comparative endocrinology, 1972, Volume: 19, Issue:1

    Topics: 17-Ketosteroids; Androstanes; Animals; Carbon Isotopes; Chromatography, Thin Layer; Crystallization;

1972
The metabolism of testostrone, androstendione and oestrone by testes from a case of testicular feminization.
    The Journal of endocrinology, 1968, Volume: 42, Issue:3

    Topics: 17-Ketosteroids; Adolescent; Androgen-Insensitivity Syndrome; Androstanes; Carbon Isotopes; Chromato

1968