Page last updated: 2024-11-07

estrone and Bonnevie-Ullrich Syndrome

estrone has been researched along with Bonnevie-Ullrich Syndrome in 22 studies

Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.

Bonnevie-Ullrich Syndrome: This syndrome that was originally observed by Ullrich, and designated as identical to TURNER SYNDROME, related the webbing of the neck, loose skin and other anomalies of the syndrome to accumulation of fluid in the embryo starting at the head and dispersing to the extremities (as observed by Bonnevie in mice). Commonly observed at birth in Turner Syndrome and NOONAN SYNDROME; EDEMA of the extremities usually recedes by one year and is an early sign of Turner syndrome, especially in female neonates.

Research Excerpts

ExcerptRelevanceReference
"Our objective was to assess metabolic effects of oral vs transdermal (TD) 17β-E₂ replacement using estrogen concentration-based dosing in girls with Turner syndrome (TS)."2.78Metabolic effects of oral versus transdermal 17β-estradiol (E₂): a randomized clinical trial in girls with Turner syndrome. ( Hossain, J; Klein, KO; Mauras, N; Mericq, V; Ross, JL; Santen, RJ; Singh, R; Taboada, M; Torres-Santiago, L; Unanue, N, 2013)
"Estrone was detected in cerebrospinal fluid before and after but not during dexamethasone treatment."1.26Pseudotumor cerebri in an obese woman with Turner syndrome. ( Binstock, ML; Donaldson, JO, 1981)
"To evaluate the relationship between the secretion of gonadotropins and adrenal androgens, patients with gonadal agenesis were evaluated by (a) administering human luteinizing hormone (hLH) for 5 days with or without estrogen pretreatment to agonadal patients who had prepubertal LH levels; (b) correlating circulating gonadotropin levels with adrenal androgens in 45 patients; and (c) comparing adrenal androgens with gonadotropins after long-term administration of estrogen or androgens."1.25Lack of correlation between gonadotropin and adrenal androgen levels in agonadal children. ( Blizzard, RM; Kowarski, A; Lee, PA; Migeon, CJ, 1975)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199019 (86.36)18.7374
1990's1 (4.55)18.2507
2000's1 (4.55)29.6817
2010's1 (4.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Torres-Santiago, L1
Mericq, V1
Taboada, M1
Unanue, N1
Klein, KO1
Singh, R1
Hossain, J1
Santen, RJ1
Ross, JL1
Mauras, N1
Bannink, EM1
van Sassen, C1
van Buuren, S1
de Jong, FH1
Lequin, M1
Mulder, PG1
de Muinck Keizer-Schrama, SM1
KELLY, LW1
Reiter, EO1
Duckett, GE1
Root, AW1
Donaldson, JO2
Horak, E1
Binstock, ML1
Lee, PA1
Kowarski, A1
Migeon, CJ1
Blizzard, RM1
Isaacs, AJ1
Havard, CW1
Nagamani, M1
Lin, TJ1
McDonough, PG1
Watatani, H1
McPherson, JC1
Mahesh, VB1
Conte, FA2
Grumbach, MM2
Kaplan, SL2
Toublanc, JE2
Grenier, J1
Nahoul, K1
Scholler, R2
Canlorbe, P2
Illig, R1
DeCampo, C1
Lang-Muritano, MR1
Prader, A1
Torresani, T1
Werder, EA1
Willi, U1
Schenkel, L1
Stone, D1
Mackay, AM1
Pettigrew, N1
Symington, T1
Neville, AM1
Howard, RP1
Keaty, EC1
Job, JC1
Garnier, PE1
Chaussain, JL1
Kelch, RP1
Rosenfield, RL1
Fang, VS1
Dupon, C2
Kim, MH2
Refetoff, S1
Bidlingmaier, F1
Wagner-Barnack, M1
Butenandt, O1
Knorr, D1
Hosseinian, AH1
Sacris, MO1
Cleary, RE1
Nankin, HR1
Loiudice, T1
Loraine, JA1
Adamopoulos, DA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Estrogen Dosing in Turner Syndrome:Pharmacology & Metabolism[NCT00837616]Phase 441 participants (Actual)Interventional2009-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Body Mass Index From Baseline at 12 Months

(NCT00837616)
Timeframe: 12 months

Interventionkg/m2 (Mean)
Oral Estradiol0.075
Transdermal Estradiol0.65

Change in Fat Free Mass From Baseline at 12 Months

(NCT00837616)
Timeframe: 12 months

Interventionkg (Mean)
Oral Estradiol1.03
Transdermal Estradiol1.67

Change in Percent Fat Mass From Baseline in 12 Months

(NCT00837616)
Timeframe: 12 months

Interventionpercent fat mass (Mean)
Oral Estradiol-0.14
Transdermal Estradiol-0.64

Change in Weight From Baseline at 12 Months

(NCT00837616)
Timeframe: 12 months

Interventionkilograms (Mean)
Oral Estradiol1.1
Transdermal Estradiol1.9

Changes in Insulin Growth Factor-I From Baseline at 12 Months

(NCT00837616)
Timeframe: 12 months

Interventionng/ml (Mean)
Oral Estradiol-16
Transdermal Estradiol28

Rates of Lipid Oxidation After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

(NCT00837616)
Timeframe: 12 months

InterventionKcal/Fat Free Mass/day (Mean)
Oral Estradiol10
Transdermal Estradiol7.3

Serum 17B Estradiol Concentrations After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

(NCT00837616)
Timeframe: 12 months

Interventionpg/ml (Mean)
Oral Estradiol124
Transdermal Estradiol74

Serum Estrone Concentrations After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

(NCT00837616)
Timeframe: 12 months

Interventionpg/mL (Mean)
Oral Estradiol504
Transdermal Estradiol43

Serum Estrone Sulfate Concentrations After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

(NCT00837616)
Timeframe: 12 months

Interventionpg/mL (Mean)
Oral Estradiol63638
Transdermal Estradiol1875

Lipids Concentrations After Using Oral Versus Transdermal 17B Estradiol Replacement for 12 Months

(NCT00837616)
Timeframe: 12 months

,
Interventionmg/dl (Mean)
Total CholesterolLow Density LipoproteinHigh Density LipoproteinTriglycerides
Oral Estradiol168935695
Transdermal Estradiol153885070

Reviews

1 review available for estrone and Bonnevie-Ullrich Syndrome

ArticleYear
Chromosomal mosaicism in the human and chromosomal change in vitro.
    Recent advances in biological psychiatry, 1966, Volume: 9

    Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes; Chromosomes, Human, 13-15; Chromosomes, H

1966

Trials

2 trials available for estrone and Bonnevie-Ullrich Syndrome

ArticleYear
Metabolic effects of oral versus transdermal 17β-estradiol (E₂): a randomized clinical trial in girls with Turner syndrome.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Basal Metabolism; Biotransformation; Body Composition; Bone

2013
Puberty induction in Turner syndrome: results of oestrogen treatment on development of secondary sexual characteristics, uterine dimensions and serum hormone levels.
    Clinical endocrinology, 2009, Volume: 70, Issue:2

    Topics: Administration, Oral; Adolescent; Breast; Child; Cross-Sectional Studies; Dose-Response Relationship

2009

Other Studies

19 other studies available for estrone and Bonnevie-Ullrich Syndrome

ArticleYear
Ovarian dwarfism with pituitary tumor.
    The Journal of clinical endocrinology and metabolism, 1963, Volume: 23

    Topics: Dwarfism; Estrone; Humans; Hypogonadism; Norethynodrel; Pituitary Neoplasms; Turner Syndrome

1963
Responses to constant infusion of LH-RH in girls with primary hypogonadism.
    Obstetrics and gynecology, 1980, Volume: 56, Issue:3

    Topics: Adolescent; Adult; Androstenedione; Child; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; E

1980
Cerebrospinal fluid oestrone in pseudotumour cerebri.
    Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:8

    Topics: Adult; Cerebrospinal Fluid Proteins; Dexamethasone; Diet, Reducing; Estradiol; Estriol; Estrone; Fem

1982
Pseudotumor cerebri in an obese woman with Turner syndrome.
    Neurology, 1981, Volume: 31, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Androstenedione; Estrogens; Estrone; Female; Humans; Menstruation; O

1981
Lack of correlation between gonadotropin and adrenal androgen levels in agonadal children.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 40, Issue:4

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androgens; Dehydroepiandrosterone; Estrogens, Conjugated (

1975
Effect of piperazine oestrone sulphate on serum lipids and lipoproteins in menopausal women.
    Acta endocrinologica, 1977, Volume: 85, Issue:1

    Topics: Cholesterol; Climacteric; Estrone; Fatty Acids; Fatty Acids, Nonesterified; Female; Humans; Lipids;

1977
Clinical and endocrine studies in menopausal women after estradiol pellet implantation.
    Obstetrics and gynecology, 1977, Volume: 50, Issue:5

    Topics: Adult; Depression, Chemical; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Lutei

1977
A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 40, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Estradiol; Estrone; Female; Follicle Stimul

1975
[Levels of estrone, estradiol 17 beta and testosterone in girls during normal puberty. Applications in pathology].
    Gynecologie, 1975, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Estradiol; Estrone; Female; Humans; Hypopituitarism; Inf

1975
A physiological mode of puberty induction in hypogonadal girls by low dose transdermal 17 beta-oestradiol.
    European journal of pediatrics, 1990, Volume: 150, Issue:2

    Topics: Administration, Cutaneous; Adolescent; Child; Estradiol; Estrone; Female; Follicle Stimulating Hormo

1990
Tumors of dysgenetic gonads (gonadoblastoma): ultrastructural and steroidogenic aspects.
    Cancer, 1974, Volume: 34, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; Androstenedione; Androstenes; Basement Membrane; Cell Nucleus; Cytopla

1974
Evaluation of equilin 3-monosulfate and other estrogens. Comparison by study of urinary gonadotropins in women.
    Archives of internal medicine, 1971, Volume: 128, Issue:2

    Topics: 17-Ketosteroids; Administration, Oral; Adult; Aged; Amenorrhea; Animals; Biological Assay; Castratio

1971
Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on the release of gonadotropins in hypophyso-gonadal disorders of children and adolescents. V. Agonadism.
    The Journal of clinical endocrinology and metabolism, 1974, Volume: 38, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Disorders of Sex Development; Estradiol; Estrone; Female; Folli

1974
Episodic secretion of luteinizing hormone (LH) in adolescent patients with the syndrome of gonadal dysgenesis.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Child; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Iodine I

1973
The effects of low doses of depot estradiol and testosterone in teenagers with ovarian failure and Turner's syndrome.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 37, Issue:4

    Topics: Adolescent; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Half-Life; Humans; Luteinizing

1973
Plasma estrogens in childhood and puberty under physiologic and pathologic conditions.
    Pediatric research, 1973, Volume: 7, Issue:11

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adult; Animals; Cattle; C

1973
Hormonal profile in patients with gonadal dysgenesis.
    American journal of obstetrics and gynecology, 1974, Apr-01, Volume: 118, Issue:7

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Androstenedione; Chorionic Gonadotropin; Depression, Che

1974
Primary amenorrhea in a 46,XX-46,XXq-female.
    Obstetrics and gynecology, 1974, Volume: 44, Issue:1

    Topics: Adult; Amenorrhea; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Karyotyping; Lu

1974
Recent studies on the estimation of human pituitary gonadotrophins in urine in clinical conditions.
    Hormones, 1970, Volume: 1, Issue:2

    Topics: Adult; Aged; Animals; Ascorbic Acid; Climacteric; Clomiphene; Contraceptives, Oral; Estradiol; Estri

1970