estrone has been researched along with Arthritis, Rheumatoid in 11 studies
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Estrone sulfate transporters were present in synovial tissue." | 5.35 | Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis. ( Capellino, S; Cutolo, M; Hartung, R; Pfeifer-Leeg, A; Schmidt, M; Straub, RH, 2009) |
| "Androgens such as dehydroepiandrosterone sulfate (DHEAS) and testosterone are markedly lower in postmenopausal women with rheumatoid arthritis (RA) than in controls." | 5.11 | Sex hormone concentrations in patients with rheumatoid arthritis are not normalized during 12 weeks of anti-tumor necrosis factor therapy. ( Atzeni, F; Cutolo, M; Härle, P; Sarzi-Puttini, P; Straub, RH; Weidler, C, 2005) |
| " The conversion of dehydroepiandrosterone (DHEA) in target macrophages leads to an increase of downstream effector hormones (including estrogens), which may be an important factor for local immunomodulation at least in RA synovitis." | 4.82 | Synovial fluid estrogens in rheumatoid arthritis. ( Capellino, S; Cutolo, M; Montagna, P; Seriolo, B; Straub, RH; Sulli, A; Villaggio, B, 2004) |
| "In patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), 17beta-estradiol was thought to play a dual pro- and antiinflammatory role depending on its concentration or probably conversion to downstream mitogenic 16 alpha-hydroxyestrone or naturally occurring antiestrogens such as 2-hydroxyestrone." | 3.72 | Patients with rheumatoid arthritis and systemic lupus erythematosus have increased renal excretion of mitogenic estrogens in relation to endogenous antiestrogens. ( Härle, P; Schedel, J; Schmidt, M; Schölmerich, J; Straub, RH; Weidler, C, 2004) |
| "Estrone sulfate transporters were present in synovial tissue." | 1.35 | Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis. ( Capellino, S; Cutolo, M; Hartung, R; Pfeifer-Leeg, A; Schmidt, M; Straub, RH, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 8 (72.73) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schmidt, M | 3 |
| Hartung, R | 1 |
| Capellino, S | 2 |
| Cutolo, M | 5 |
| Pfeifer-Leeg, A | 1 |
| Straub, RH | 6 |
| Castagnetta, LA | 1 |
| Carruba, G | 1 |
| Granata, OM | 1 |
| Stefano, R | 1 |
| Miele, M | 1 |
| Weidler, C | 2 |
| Härle, P | 3 |
| Schedel, J | 1 |
| Schölmerich, J | 1 |
| Villaggio, B | 1 |
| Seriolo, B | 1 |
| Montagna, P | 1 |
| Sulli, A | 1 |
| Tengstrand, B | 1 |
| Carlström, K | 1 |
| Felländer-Tsai, L | 1 |
| Hafström, I | 1 |
| EDELSTEIN, H | 1 |
| Atzeni, F | 1 |
| Sarzi-Puttini, P | 1 |
| Yamana, S | 1 |
| Matsuda, T | 1 |
| Takasugi, K | 1 |
| Kishimoto, T | 1 |
| Nishimoto, N | 1 |
| Bijlsma, JW | 1 |
| Duursma, SA | 1 |
| Thijssen, JH | 1 |
| Huber, O | 1 |
| Flaisler, F | 1 |
| Hedon, B | 1 |
| Sany, J | 1 |
| Combe, B | 1 |
1 review available for estrone and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Synovial fluid estrogens in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; B-Lymphocytes; Cytokines; Dehydroepiandrosterone; Estriol; Estrogens; Female; | 2004 |
2 trials available for estrone and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Sex hormone concentrations in patients with rheumatoid arthritis are not normalized during 12 weeks of anti-tumor necrosis factor therapy.
Topics: Adalimumab; Aged; Androstenedione; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirh | 2005 |
Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Androgens; A | 2006 |
8 other studies available for estrone and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis.
Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Aged; Arthritis, Rheumatoid; Case-Control Studies; Cells, C | 2009 |
Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Adult; Androgens; Arthritis, Rheumatoid; Dehydroepiandrosterone; Estradiol; | 2003 |
Estrogen metabolites: increasing evidence for their role in rheumatoid arthritis and systemic lupus erythematosus.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Autoimmunity; Estrogens; Female; Humans; Hydroxyestrones | 2004 |
Patients with rheumatoid arthritis and systemic lupus erythematosus have increased renal excretion of mitogenic estrogens in relation to endogenous antiestrogens.
Topics: Arthritis, Rheumatoid; Estrogen Receptor Modulators; Estrogens; Female; Humans; Hydroxyestrones; Lup | 2004 |
Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rheumatoid arthritis: high correlation between serum estradiol and current degree of inflammation.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Case-Control Studies; Dehydroepiandrosterone; | 2003 |
[The hormone estrone in the treatment of chronic postmenopausal non-inflammatory rheumatism].
Topics: Arthritis, Rheumatoid; Estrone; Humans; Neoplasms, Hormone-Dependent; Postmenopause; Rheumatic Disea | 1950 |
Influence of nandrolondecanoate on the pituitary-gonadal axis in males.
Topics: Adult; Anabolic Agents; Androstenedione; Arthritis, Rheumatoid; Bone and Bones; Estradiol; Estrone; | 1982 |
A study of ovarian function in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Case-Control Studies; Estradiol; Estrogens; Estrone; Female; Humans; M | 1995 |