estrone has been researched along with Alzheimer Disease in 11 studies
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether an association exists between estradiol and estrone levels and measures of cognitive functioning in women with Alzheimer disease (AD) treated with conjugated equine estrogen (Premarin; Wyeth-Ayerst, Philadelphia, Pa)." | 5.10 | Estrogen levels do not correlate with improvement in cognition. ( Grundman, M; Mulnard, R; Sano, M; Schneider, L; Thal, LJ; Thomas, RG, 2003) |
| "05 mg/day dosage of 17 beta-estradiol via a skin patch and the remaining six wore a placebo skin patch." | 2.69 | Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. ( Asthana, S; Baker, LD; Birnbaum, RS; Craft, S; Lofgreen, CP; Plymate, SR; Raskind, MA; Veith, RC, 1999) |
| "Seven women with senile dementia-Alzheimer's type (SDAT) were treated with conjugated estrogen [main content: estrone sulfate (E1-S)], at a dose of 1." | 2.66 | In vivo effects by estrone sulfate on the central nervous system-senile dementia (Alzheimer's type). ( Honjo, H; Ishihara, S; Kitawaki, J; Naitoh, K; Ogino, Y; Okada, H; Urabe, M; Yamamoto, T; Yasuda, J; Yonezawa, T, 1989) |
| "Estrone sulfate (E1-S) has been shown to be quantitatively the most important estrogen in peripheral blood." | 1.28 | [Tissue culture and estrogen, to clarify the roles of estrone sulfate]. ( Honjo, H; Kitawaki, J; Naitoh, K; Ogino, Y; Okada, H; Urabe, M; Yamamoto, T; Yasuda, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Boutin, S | 2 |
| Maltais, R | 2 |
| Roy, J | 2 |
| Poirier, D | 2 |
| Alata, W | 1 |
| Calon, F | 1 |
| Thal, LJ | 1 |
| Thomas, RG | 1 |
| Mulnard, R | 1 |
| Sano, M | 1 |
| Grundman, M | 1 |
| Schneider, L | 1 |
| Hoskin, EK | 1 |
| Tang, MX | 1 |
| Manly, JJ | 1 |
| Mayeux, R | 1 |
| Simpkins, JW | 1 |
| Wen, Y | 1 |
| Perez, E | 1 |
| Yang, S | 1 |
| Wang, X | 1 |
| Schneider, LS | 1 |
| Farlow, MR | 1 |
| Henderson, VW | 1 |
| Pogoda, JM | 1 |
| Asthana, S | 1 |
| Craft, S | 1 |
| Baker, LD | 1 |
| Raskind, MA | 1 |
| Birnbaum, RS | 1 |
| Lofgreen, CP | 1 |
| Veith, RC | 1 |
| Plymate, SR | 1 |
| Cunningham, CJ | 1 |
| Sinnott, M | 1 |
| Denihan, A | 1 |
| Rowan, M | 1 |
| Walsh, JB | 1 |
| O'Moore, R | 1 |
| Coakley, D | 1 |
| Coen, RF | 1 |
| Lawler, BA | 1 |
| O'Neill, DD | 1 |
| Hogervorst, E | 1 |
| Smith, AD | 1 |
| Honjo, H | 2 |
| Urabe, M | 2 |
| Naitoh, K | 2 |
| Ogino, Y | 2 |
| Kitawaki, J | 2 |
| Yasuda, J | 2 |
| Yamamoto, T | 2 |
| Okada, H | 2 |
| Ishihara, S | 1 |
| Yonezawa, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Alzheimer's Disease: Therapeutic Potential of Estrogen[NCT00066157] | Phase 2/Phase 3 | 42 participants (Actual) | Interventional | 2001-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for estrone and Alzheimer Disease
| Article | Year |
|---|---|
Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology.
Topics: Alzheimer Disease; Animals; Apoptosis; Brain Ischemia; Cyclin-Dependent Kinases; Disease Models, Ani | 2005 |
4 trials available for estrone and Alzheimer Disease
| Article | Year |
|---|---|
Estrogen levels do not correlate with improvement in cognition.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Estradiol; Estrogens, Conjugated (USP); Estrone; Femal | 2003 |
Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Combined Modality | 1996 |
Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Alzheimer Disease; Climacteric; Double-Blind Met | 1999 |
In vivo effects by estrone sulfate on the central nervous system-senile dementia (Alzheimer's type).
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Estrogens, Conjugated (USP); Estrone; Female; Humans; Ma | 1989 |
6 other studies available for estrone and Alzheimer Disease
| Article | Year |
|---|---|
Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency.
Topics: 17-Hydroxysteroid Dehydrogenases; Alzheimer Disease; Biocatalysis; Drug Evaluation, Preclinical; Enz | 2021 |
Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10.
Topics: 17-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Alzheimer Disease; Enzyme Inhibitors; | 2018 |
Elevated sex-hormone binding globulin in elderly women with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Analysis of Variance; Apolipoprotein E4; Apolipop | 2004 |
Endogenous sex hormone levels in postmenopausal women with Alzheimer's disease.
Topics: Aged; Alcohol Drinking; Alzheimer Disease; Androstenedione; Body Mass Index; Cognition; Depression; | 2001 |
The interaction of serum folate and estradiol levels in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Estradiol; Estrone; Female; Folic Acid; Humans; Logistic | 2002 |
[Tissue culture and estrogen, to clarify the roles of estrone sulfate].
Topics: Alzheimer Disease; Breast Neoplasms; Culture Techniques; Endometrial Neoplasms; Endometrium; Estradi | 1989 |