estriol has been researched along with Smith-Lemli-Opitz Syndrome in 18 studies
hormonin: estrogen replacement; each tablet contains 600 ug micronized 17beta-estradiol, 270 ug estriol and 1.4 mg estrone
chlorapatite : A phosphate mineral with the formula Ca5(PO4)3Cl.
Smith-Lemli-Opitz Syndrome: An autosomal recessive disorder of CHOLESTEROL metabolism. It is caused by a deficiency of 7-dehydrocholesterol reductase, the enzyme that converts 7-dehydrocholesterol to cholesterol, leading to an abnormally low plasma cholesterol. This syndrome is characterized by multiple CONGENITAL ABNORMALITIES, growth deficiency, and INTELLECTUAL DISABILITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the clinical value of low maternal serum unconjugated estriol (E3) level for diagnosing Smith-Lemli-Opitz syndrome and other fetal clinical conditions in pregnant members of a large health maintenance organization." | 7.72 | Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions. ( Krieger, R; Norem, C; O'Keefe, J; Schoen, E; To, TT; Walton, D, 2003) |
| "[structure: see text] Brief partial syntheses are described for ring B unsaturated estriols, which are candidate metabolites diagnostic for Smith-Lemli-Opitz syndrome prenatally." | 7.71 | Synthesis of ring B unsaturated estriols. Confirming the structure of a diagnostic analyte for Smith-Lemli-Opitz syndrome. ( Guo, LW; Shackleton, CH; Wilson, WK, 2001) |
| "Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive disorder caused by reduced activity of 7-dehydrocholesterol (7DHC) reductase, resulting in a decreased level of cholesterol and increased concentrations of 7DHC and 8DHC in body fluids and tissues." | 3.73 | Maternal urinary steroid profiles in prenatal diagnosis of Smith-Lemli-Opitz syndrome: first patient series comparing biochemical and molecular studies. ( Ciara, E; Czerwiecka, M; Goryluk-Kozakiewicz, B; Jezela-Stanek, A; Jezuita, J; Krajewska-Walasek, M; Małunowicz, EM; Nowaczyk, MJ; Popowska, E; Spodar, K, 2006) |
| "To assess the clinical value of low maternal serum unconjugated estriol (E3) level for diagnosing Smith-Lemli-Opitz syndrome and other fetal clinical conditions in pregnant members of a large health maintenance organization." | 3.72 | Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions. ( Krieger, R; Norem, C; O'Keefe, J; Schoen, E; To, TT; Walton, D, 2003) |
| "[structure: see text] Brief partial syntheses are described for ring B unsaturated estriols, which are candidate metabolites diagnostic for Smith-Lemli-Opitz syndrome prenatally." | 3.71 | Synthesis of ring B unsaturated estriols. Confirming the structure of a diagnostic analyte for Smith-Lemli-Opitz syndrome. ( Guo, LW; Shackleton, CH; Wilson, WK, 2001) |
| "The equine-type estriols 1,3,5(10),7-estratetraene-3,16alpha,17beta-triol (16alpha-hydroxy-17beta-dihydroequilin) and 1,3,5(10),6,8-estrapentaene-3,16alpha,17beta-triol (16alpha-hydroxy-17beta-dihydroequilenin) constituted over half of the estrogens excreted by a woman carrying a Smith-Lemli-Opitz syndrome (SLOS) affected fetus." | 3.70 | Equine type estrogens produced by a pregnant woman carrying a Smith-Lemli-Opitz syndrome fetus. ( Kelley, RI; Kratz, LE; Roitman, E; Shackleton, CH, 1999) |
| "We selected 14 cases of trisomy 18 and 3 cases of SLO in which the maternal uE(3) level was decreased and reported malformations were observed after fetopathological examination." | 1.40 | Involvement and alteration of the Sonic Hedgehog pathway is associated with decreased cholesterol level in trisomy 18 and SLO amniocytes. ( Bigot, N; Galera, P; Gruchy, N; Jeanne Pasquier, C; Leporrier, N; Odent, S; Read, MH, 2014) |
| "The DR and SPR for trisomy 21 (N = 827) during the quadruple-marker time period were 75." | 1.37 | Detection rate of quadruple-marker screening determined by clinical follow-up and registry data in the statewide California program, July 2007 to February 2009. ( Currier, RJ; Flessel, M; Goldman, S; Hennigan, C; Hodgkinson, C; Kazerouni, NN; Lorey, F; Malm, L; Roberson, M; Tempelis, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 10 (55.56) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gruchy, N | 1 |
| Bigot, N | 1 |
| Jeanne Pasquier, C | 1 |
| Read, MH | 1 |
| Odent, S | 1 |
| Galera, P | 1 |
| Leporrier, N | 1 |
| Jelliffe-Pawlowski, LL | 1 |
| Walton-Haynes, L | 1 |
| Currier, RJ | 2 |
| Marcos, J | 2 |
| Craig, WY | 4 |
| Palomaki, GE | 5 |
| Kloza, EM | 1 |
| Haddow, JE | 5 |
| Roberson, M | 3 |
| Bradley, LA | 4 |
| Shackleton, CH | 5 |
| Kazerouni, NN | 1 |
| Flessel, M | 1 |
| Goldman, S | 1 |
| Hennigan, C | 1 |
| Hodgkinson, C | 1 |
| Lorey, F | 1 |
| Malm, L | 1 |
| Tempelis, C | 1 |
| Schoen, E | 1 |
| Norem, C | 1 |
| O'Keefe, J | 1 |
| Krieger, R | 1 |
| Walton, D | 1 |
| To, TT | 1 |
| Shinawi, M | 1 |
| Szabo, S | 1 |
| Popek, E | 1 |
| Wassif, CA | 1 |
| Porter, FD | 1 |
| Potocki, L | 1 |
| Jezela-Stanek, A | 1 |
| Małunowicz, EM | 1 |
| Ciara, E | 1 |
| Popowska, E | 1 |
| Goryluk-Kozakiewicz, B | 1 |
| Spodar, K | 1 |
| Czerwiecka, M | 1 |
| Jezuita, J | 1 |
| Nowaczyk, MJ | 1 |
| Krajewska-Walasek, M | 1 |
| Kelley, RI | 5 |
| Kratz, LE | 3 |
| Canick, JA | 1 |
| Abuelo, DN | 1 |
| Tint, GS | 2 |
| Knight, GJ | 2 |
| Opitz, JM | 1 |
| Irons, M | 1 |
| Bick, DP | 1 |
| McCorkle, D | 1 |
| Stanley, WS | 1 |
| Stern, HJ | 1 |
| Staszak, P | 1 |
| Berkovitz, GD | 1 |
| Meyers, CM | 1 |
| Roitman, E | 2 |
| Craig, JE | 1 |
| Savage, V | 1 |
| Cowley, D | 1 |
| Clague, A | 1 |
| Glass, IA | 1 |
| Kratz, L | 1 |
| Kelley, R | 1 |
| Guo, LW | 1 |
| Wilson, WK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Feasibility of Screening for Smith-Lemli-Opitz Syndrome[NCT00070850] | 1,800 participants | Observational | 2001-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for estriol and Smith-Lemli-Opitz Syndrome
| Article | Year |
|---|---|
Recognition of Smith-Lemli-Opitz syndrome (RSH) in the fetus: utility of ultrasonography and biochemical analysis in pregnancies with low maternal serum estriol.
Topics: DNA Mutational Analysis; Estriol; Fatal Outcome; Female; Fetal Diseases; Humans; Male; Mutation, Mis | 2005 |
Levels of unconjugated estriol and other maternal serum markers in pregnancies with Smith-Lemli-Opitz (RSH) syndrome fetuses.
Topics: alpha-Fetoproteins; Biomarkers; Chorionic Gonadotropin; Estriol; Female; Genetic Testing; Humans; Pr | 1999 |
Prenatal diagnosis of Smith-Lemli-Opitz syndrome in a pregnancy with low maternal serum oestriol and a sex-reversed fetus.
Topics: Adult; Amniotic Fluid; Dehydrocholesterols; Diagnosis, Differential; Disorders of Sex Development; E | 1999 |
1 trial available for estriol and Smith-Lemli-Opitz Syndrome
| Article | Year |
|---|---|
Dehydrosteroid measurements in maternal urine or serum for the prenatal diagnosis of Smith-Lemli-Opitz syndrome (SLOS).
Topics: Estriol; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Pregnancy; Pregnanetriol; Smith | 2007 |
14 other studies available for estriol and Smith-Lemli-Opitz Syndrome
| Article | Year |
|---|---|
Involvement and alteration of the Sonic Hedgehog pathway is associated with decreased cholesterol level in trisomy 18 and SLO amniocytes.
Topics: Amniotic Fluid; Atorvastatin; Bone Morphogenetic Protein 2; Cells, Cultured; Cholesterol; Chromosome | 2014 |
Using second trimester ultrasound and maternal serum biomarker data to help detect congenital heart defects in pregnancies with positive triple-marker screening results.
Topics: alpha-Fetoproteins; Biomarkers; Chorionic Gonadotropin; Chromosomes, Human, Pair 18; Chromosomes, Hu | 2008 |
Maternal urine and serum steroid measurements to identify steroid sulfatase deficiency (STSD) in second trimester pregnancies.
Topics: Androsterone; Dehydroepiandrosterone; Estriol; False Positive Reactions; Female; Gas Chromatography- | 2009 |
Detection rate of quadruple-marker screening determined by clinical follow-up and registry data in the statewide California program, July 2007 to February 2009.
Topics: Adult; alpha-Fetoproteins; Biomarkers; California; Chorionic Gonadotropin; Chromosome Aberrations; C | 2011 |
Maternal serum unconjugated estriol as a predictor for Smith-Lemli-Opitz syndrome and other fetal conditions.
Topics: Adult; Biomarkers; Cohort Studies; Estriol; Female; Fetal Diseases; Fetal Viability; Gestational Age | 2003 |
Maternal urinary steroid profiles in prenatal diagnosis of Smith-Lemli-Opitz syndrome: first patient series comparing biochemical and molecular studies.
Topics: Adult; Amniotic Fluid; Chorionic Villi Sampling; Dehydrocholesterols; Estriol; Family; Female; Gas C | 2006 |
Major fetal abnormalities associated with positive screening tests for Smith-Lemli-Opitz syndrome (SLOS).
Topics: Adult; alpha-Fetoproteins; California; Chorionic Gonadotropin; Down Syndrome; Estriol; Female; Human | 2007 |
Maternal serum marker levels in two pregnancies affected with Smith-Lemli-Opitz syndrome.
Topics: alpha-Fetoproteins; Chorionic Gonadotropin; Estriol; Female; Humans; Pregnancy; Smith-Lemli-Opitz Sy | 1997 |
Prenatal diagnosis of the RSH/Smith-Lemli-Opitz syndrome.
Topics: Amniotic Fluid; Cholesterol; Chorionic Villi; Dehydrocholesterols; Estriol; Female; Humans; Models, | 1999 |
Equine type estrogens produced by a pregnant woman carrying a Smith-Lemli-Opitz syndrome fetus.
Topics: Adult; Animals; Estriol; Female; Horses; Humans; Pregnancy; Smith-Lemli-Opitz Syndrome | 1999 |
Low maternal serum oestriol at mid-trimester may indicate a fetal disorder of cholesterol biosynthesis.
Topics: Adult; Estriol; Fatal Outcome; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Pregnancy; Pre | 1999 |
Dehydro-oestriol and dehydropregnanetriol are candidate analytes for prenatal diagnosis of Smith-Lemli-Opitz syndrome.
Topics: Biomarkers; Estriol; Female; Gas Chromatography-Mass Spectrometry; Humans; Predictive Value of Tests | 2001 |
Synthesis of ring B unsaturated estriols. Confirming the structure of a diagnostic analyte for Smith-Lemli-Opitz syndrome.
Topics: Biomarkers; Estriol; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Smith-Lemli-Opit | 2001 |
Assigning risk for Smith-Lemli-Opitz syndrome as part of 2nd trimester screening for Down's syndrome.
Topics: alpha-Fetoproteins; Biomarkers; Chorionic Gonadotropin; Down Syndrome; Estriol; Female; Humans; Preg | 2002 |