Page last updated: 2024-11-06

estriol and Osteoporosis, Postmenopausal

estriol has been researched along with Osteoporosis, Postmenopausal in 23 studies

hormonin: estrogen replacement; each tablet contains 600 ug micronized 17beta-estradiol, 270 ug estriol and 1.4 mg estrone
chlorapatite : A phosphate mineral with the formula Ca5(PO4)3Cl.

Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.

Research Excerpts

ExcerptRelevanceReference
" Postmenopausal genital and urinary problems with recurrent infections, incontinence, and dyspareunia can effectively be treated by vaginal application of estriol, which seems to be safe for women treated for breast cancer."4.91Hormones, herbal preparations and nutriceuticals for a better life after the menopause: part I. ( Comhaire, FH; Depypere, HT, 2015)
"The frequency and severity of treatment-related uterine bleeding decreased with the duration of Kliogest treatment."2.71Effect of combined oral estrogen/progestogen preparation (Kliogest) on bone mineral density, plasma lipids and postmenopausal symptoms in HRT-naïve Thai women. ( Jirapinyo, M; Jorgensen, LN; Manonai, J; Suchartwatnachai, C; Theppisai, U, 2003)
" Although a lower dosage of estriol may be recommended for elderly subjects, these observations suggest that hormone replacement therapy with estriol is effective against degenerative osteoporosis, and that low-turnover bones in elderly women are also responsive to estriol."2.68[Effect of estriol and bone mineral density of lumbar vertebrae in elderly and postmenopausal women]. ( Fukuo, K; Hirota, K; Ikegami, H; Morimoto, S; Nishibe, A; Ogihara, T; Onishi, T; Yamamoto, T; Yasuda, O, 1996)
"Estriol prevented postmenopausal bone loss and improved climacteric symptoms effectively with low incidence of genital bleeding."2.68Effect of estriol on bone loss in postmenopausal Japanese women: a multicenter prospective open study. ( Aso, T; Fukunaga, M; Ibuki, Y; Ikeda, T; Kato, J; Kinoshita, T; Koyama, T; Kurabayashi, T; Kusuhara, K; Minagawa, Y; Minaguchi, H; Mizunuma, H; Nozawa, S; Ochiai, K; Ohta, H; Sato, A; Shirasu, K; Tanaka, K; Tsukikawa, S; Uemura, T, 1996)
"Estriol has been found to provide some of the protection without the risks associated with stronger estrogens."2.40Estriol: safety and efficacy. ( Head, KA, 1998)
"Estriol was very effective in the improvement of major subjective climacteric complaints in 86% of patients, especially hot flush and insomnia within 3 months."1.29Efficacy and safety of estriol replacement therapy for climacteric women. ( Chang, SP; Ng, HT; Tsan, SH; Yang, TS, 1995)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's10 (43.48)18.2507
2000's9 (39.13)29.6817
2010's2 (8.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Comhaire, FH1
Depypere, HT1
Sliwiński, L1
Folwarczna, J1
Nowińska, B1
Cegieła, U1
Pytlik, M1
Kaczmarczyk-Sedlak, I1
Trzeciak, H1
Trzeciak, HI1
Kika, G1
Izumi, S1
Mori, A1
Murano, T1
Suzuki, T1
Cai, LY1
Nakamura, E1
Goya, K1
Maeda, H1
Uchida, N1
Shida, M1
Miao, Q1
Li, JG1
Miao, S1
Hu, N1
Zhang, J1
Zhang, S1
Xie, YH1
Wang, JB1
Wang, SW1
Jirapinyo, M1
Theppisai, U1
Manonai, J1
Suchartwatnachai, C1
Jorgensen, LN1
Palomba, S1
Orio, F1
Russo, T1
Colao, A1
Lombardi, G1
Zullo, F1
Yamanaka, Y1
Matsuo, H1
Mochizuki, S1
Nakago, S1
Yoshida, S1
Maruo, T1
Mizunuma, H2
Terauchi, M1
Obayashi, S1
Aso, T2
Stanosz, S1
Zochowska, E1
Stanosz, M1
Yang, TS1
Tsan, SH1
Chang, SP1
Ng, HT1
Holland, EF1
Leather, AT1
Studd, JW1
Dören, M2
Schneider, HP2
Hanabayashi, T1
Imai, A1
Tamaya, T1
Nozaki, M1
Hashimoto, K1
Inoue, Y1
Sano, M1
Nakano, H1
Nishibe, A1
Morimoto, S1
Hirota, K1
Yasuda, O1
Ikegami, H1
Yamamoto, T1
Fukuo, K1
Onishi, T1
Ogihara, T1
Melis, GB1
Cagnacci, A1
Bruni, V1
Falsetti, L1
Jasonni, VM1
Nappi, C1
Polatti, F1
Volpe, A1
Minaguchi, H1
Uemura, T1
Shirasu, K1
Sato, A1
Tsukikawa, S1
Ibuki, Y1
Koyama, T1
Nozawa, S1
Ohta, H1
Ikeda, T1
Kusuhara, K1
Ochiai, K1
Kato, J1
Kinoshita, T1
Tanaka, K1
Minagawa, Y1
Kurabayashi, T1
Fukunaga, M1
Head, KA1
Xu, K1
Liu, H1
Bi, S1
Yang, S1
Tan, J1
Hayashi, T1
Ito, I1
Kano, H1
Endo, H1
Iguchi, A1
Montag, M1
Steiniche, T1
Hasling, C1
Charles, P1
Eriksen, EF1
Mosekilde, L1
Melsen, F1

Reviews

3 reviews available for estriol and Osteoporosis, Postmenopausal

ArticleYear
Hormones, herbal preparations and nutriceuticals for a better life after the menopause: part I.
    Climacteric : the journal of the International Menopause Society, 2015, Volume: 18, Issue:3

    Topics: Breast Neoplasms; Cardiovascular Diseases; Dietary Supplements; Dyspareunia; Estradiol; Estriol; Est

2015
[Treatment of osteoporosis with estrogen].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 2

    Topics: Bone Density; Breast Neoplasms; Endometrial Neoplasms; Estriol; Estrogen Replacement Therapy; Estrog

2004
Estriol: safety and efficacy.
    Alternative medicine review : a journal of clinical therapeutic, 1998, Volume: 3, Issue:2

    Topics: Estriol; Estrogen Replacement Therapy; Estrogens; Female; Heart Diseases; Humans; Menopause; Osteopo

1998

Trials

12 trials available for estriol and Osteoporosis, Postmenopausal

ArticleYear
Beneficial aspect of oral estriol as hormone replacement therapy: consideration on bone and lipid metabolism.
    The Tokai journal of experimental and clinical medicine, 2009, Sep-20, Volume: 34, Issue:3

    Topics: Bone and Bones; Bone Density; Estriol; Estrogen Replacement Therapy; Female; Humans; Lipid Metabolis

2009
Effect of combined oral estrogen/progestogen preparation (Kliogest) on bone mineral density, plasma lipids and postmenopausal symptoms in HRT-naïve Thai women.
    Acta obstetricia et gynecologica Scandinavica, 2003, Volume: 82, Issue:9

    Topics: Administration, Oral; Aged; Bone Density; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Bl

2003
Dose reduction and discontinuation of alendronate in postmenopausal osteoporotic women who were receiving estrogen therapy.
    Fertility and sterility, 2004, Volume: 81, Issue:2

    Topics: Alendronate; Bone Density; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administratio

2004
[Biochemical aspects of modified, transdermal replacement hormone therapy].
    Ginekologia polska, 2007, Volume: 78, Issue:12

    Topics: Administration, Cutaneous; Adult; Analysis of Variance; Bone Density; Estriol; Estrogen Replacement

2007
Increase in bone mass of older postmenopausal women with low mineral bone density after one year of percutaneous oestradiol implants.
    British journal of obstetrics and gynaecology, 1995, Volume: 102, Issue:3

    Topics: Absorptiometry, Photon; Administration, Cutaneous; Aged; Bone Density; Drug Implants; Estriol; Estro

1995
Effects of ipriflavone and estriol on postmenopausal osteoporotic changes.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1995, Volume: 51, Issue:1

    Topics: Bone Density; Estriol; Female; Humans; Isoflavones; Osteoporosis, Postmenopausal

1995
[Usefulness of estriol for the treatment of bone loss in postmenopausal women].
    Nihon Sanka Fujinka Gakkai zasshi, 1996, Volume: 48, Issue:2

    Topics: Absorptiometry, Photon; Alkaline Phosphatase; Amino Acids; Bone Density; Calcium; Estriol; Female; H

1996
[Effect of estriol and bone mineral density of lumbar vertebrae in elderly and postmenopausal women].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1996, Volume: 33, Issue:5

    Topics: Aged; Aged, 80 and over; Bone Density; Estriol; Estrogen Replacement Therapy; Female; Humans; Lumbar

1996
Effect of estriol on bone loss in postmenopausal Japanese women: a multicenter prospective open study.
    The journal of obstetrics and gynaecology research, 1996, Volume: 22, Issue:3

    Topics: Bone Density; Climacteric; Estriol; Female; Humans; Middle Aged; Osteoporosis, Postmenopausal; Prosp

1996
Estriol (E3) replacement improves endothelial function and bone mineral density in very elderly women.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2000, Volume: 55, Issue:4

    Topics: Aged; Aged, 80 and over; Bone and Bones; Bone Density; Bone Resorption; Brachial Artery; Endothelium

2000
[Prospective perimenopausal estrogen-progestin substitution therapies for the prevention of osteoporosis].
    Archives of gynecology and obstetrics, 1989, Volume: 245, Issue:1-4

    Topics: Clinical Trials as Topic; Drug Therapy, Combination; Estradiol; Estriol; Female; Humans; Medroxyprog

1989
A randomized study on the effects of estrogen/gestagen or high dose oral calcium on trabecular bone remodeling in postmenopausal osteoporosis.
    Bone, 1989, Volume: 10, Issue:5

    Topics: Administration, Oral; Aged; Bone Density; Calcium; Drug Combinations; Estradiol; Estriol; Female; Hu

1989

Other Studies

8 other studies available for estriol and Osteoporosis, Postmenopausal

ArticleYear
A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system.
    Acta biochimica Polonica, 2009, Volume: 56, Issue:2

    Topics: Animals; Body Weight; Bone and Bones; Bone Density; Bone Marrow Cells; Bone Resorption; Calcificatio

2009
The bone-protective effect of genistein in the animal model of bilateral ovariectomy: roles of phytoestrogens and PTH/PTHR1 against post-menopausal osteoporosis.
    International journal of molecular sciences, 2012, Volume: 13, Issue:1

    Topics: Alkaline Phosphatase; Animals; Bone Density; Creatinine; Disease Models, Animal; Estriol; Female; Fe

2012
Effects of estriol on cell viability and 1,25-dihydroxyvitamin D3 receptor mRNA expression in cultured human osteoblast-like cells.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2003, Volume: 17, Issue:6

    Topics: Calcitriol; Cell Survival; Cells, Cultured; Estradiol; Estriol; Female; Humans; Osteoblasts; Osteopo

2003
Estriol, conjugated equine estrogens, and alendronate therapy for osteoporosis.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2006, Volume: 92, Issue:2

    Topics: Adult; Aged; Alendronate; Bone Density Conservation Agents; Estriol; Estrogens; Estrogens, Conjugate

2006
Efficacy and safety of estriol replacement therapy for climacteric women.
    Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 1995, Volume: 55, Issue:5

    Topics: Adult; Climacteric; Estriol; Estrogen Replacement Therapy; Female; Humans; Middle Aged; Osteoporosis

1995
Estrogen-progestogen replacement therapy in postmenopausal women--is 1 mg estradiolvalerate sufficient to maintain axial trabecular bone density?
    International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:5

    Topics: Administration, Oral; Bone Density; Estradiol; Estriol; Estrogen Replacement Therapy; Estrogens, Con

1994
Salmon calcitonin plus intravaginal estriol: an effective treatment for the menopause.
    Maturitas, 1996, Volume: 24, Issue:1-2

    Topics: Absorptiometry, Photon; Administration, Intranasal; Administration, Intravaginal; Alkaline Phosphata

1996
[An endometrium morphometry study on ovariectomized rats subjected to nilestriol and estradiol replalcement therapies].
    Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1998, Volume: 29, Issue:3

    Topics: Animals; Endometrium; Estradiol; Estriol; Estrogen Replacement Therapy; Female; Humans; Hyperplasia;

1998