estramustine and Penile-Neoplasms

Prostatic carcinoma metastatic to the penis is a rare phenomenon. We report two cases of acute urinary retention due to penile metastases from a prostatic carcinoma. Patients may have a penile mass or diffuse swelling of the penis. Some patients develop priapism and urinary retention can be rarely observed. The most effective treatment seems to be local excision with wide resection and, if necessary, total penectomy. The prognosis remains poor regardless of the type of therapy employed.

Topics: Adenocarcinoma; Aged; Aged, 80 and over; Amputation, Surgical; Biopsy; Cystoscopy; Estramustine; Humans; Male; Middle Aged; Neoplasm Staging; Penile Neoplasms; Phlebography; Prognosis; Prostatic Neoplasms; Survival Rate; Urinary Retention

A 77-year-old man presented with complaints of dysuria, nocturia and painless nodule on his penis. Laboratory examination revealed elevated serum prostate-specific antigen (PSA) and CA19-9. Pathological examinations on prostate and penile biopsy specimens revealed prostate adenocarcinoma with penile metastasis. The patient was diagnosed as having prostate cancer stage D2 (T4N1M1) with bone, lymph node and penile metastases. There was no response to initial hormonal therapy with the surgical castration and diethylstilbestrol. However, decrease of the tumor size, as well as PSA and CA19-9 values were achieved after the combined chemotherapy with Estramustine, Paclitaxel and Carboplatin.

Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; CA-19-9 Antigen; Carboplatin; Combined Modality Therapy; Estramustine; Humans; Male; Orchiectomy; Paclitaxel; Penile Neoplasms; Prostate-Specific Antigen; Prostatic Neoplasms

A 62-year-old patient was referred with the suspected diagnosis of Peyronie disease. The patient showed the clinical picture of a beginning malignant priapism with hematogenous metastases from an recurrent prostatic carcinoma. The penile metastases were misdiagnosed as Peyronie disease. Although both clinical pictures show some superficial similarity, Peyronie disease usually fulfills classical criteria which help to clearly distinguish it from neoplastic diseases.

Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Diagnosis, Differential; Drug Therapy, Combination; Epirubicin; Estramustine; Flutamide; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Orchiectomy; Palliative Care; Penile Induration; Penile Neoplasms; Priapism; Prostatic Neoplasms; Time Factors

Prostatic carcinoma metastasizing to the penis is rare. A case of adenocarcinoma of the prostate with metastases to the penile shaft and glans penis is presented.

Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Hormonal; Estramustine; Humans; Magnetic Resonance Imaging; Male; Neoplasm Metastasis; Orchiectomy; Penile Neoplasms; Prostate-Specific Antigen; Prostatic Neoplasms

In a 68-year-old man metastasis to the penis was diagnosed about two years after transurethral resection of the prostate because of adenocarcinoma. Diethylstilboestrol has been given postoperatively. Initially the metastasis was interpreted as primary cancer of the penis, as biopsy findings indicated a spinocellular carcinoma. Subsequent biopsies, however, showed the same histologic pattern as in the original cancer of the prostate. Up to 1976 about 170 cases of metastasis to the penis were reported in the literature. The prognosis as a rule is very poor. In the present case estramustine phosphate (Estracyt) seemed to improve the patients's general health, but did not affect the penile metastasis. The patient died 18 months after the metastasis had been demonstrated.

Topics: Adenocarcinoma; Aged; Castration; Diethylstilbestrol; Estramustine; Humans; Male; Penile Neoplasms; Prognosis; Prostatic Neoplasms