estramustine has been researched along with Adenoviridae-Infections* in 1 studies
1 other study(ies) available for estramustine and Adenoviridae-Infections
| Article | Year |
|---|---|
Estramustine phosphate reversibly inhibits an early stage during adenovirus replication.
Estramustine phosphate, an estradiol-mustard conjugate, was shown to reversibly inhibit a stage during the first hour of productive adenovirus 2 infection of HeLa cells. This drug, employed in the therapy of advanced prostatic cancer, specifically interacts with microtubule-associated proteins (MAPs) of the cytoskeleton. The results obtained under physiological conditions in vivo suggest a MAPs-interference with the microtubule-mediated vectorial migration of the virus inoculum to the nucleus. Virus attachment, uncoating kinetics and the appearance of established uncoating intermediates were not affected. Topics: Adenoviridae Infections; Adenoviruses, Human; Antigens, Viral; Capsid; Centrifugation, Density Gradient; Estramustine; HeLa Cells; Humans; Kinetics; Microtubule-Associated Proteins; Microtubules; Nitrogen Mustard Compounds; Virus Replication | 1990 |