esculetin and Edema
esculetin has been researched along with Edema* in 2 studies
Other Studies
2 other study(ies) available for esculetin and Edema
| Article | Year |
|---|---|
Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase.
The anti-inflammatory activity of three benzo-pyrones with prevalent lipooxigenase-inhibitory activity was studied using the Croton oil ear test in mice, in comparison with nordihydroguaieretic acid (NDGA) and indomethacin. Kaempferol, quercetin and NDGA possess a strong and prolonged anti-inflammatory effect, whereas the action of indomethacin appears relevant, but not long-lasting. In contrast the anti-inflammatory activity of esculetin is rather weak, but persistent. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Croton Oil; Cyclooxygenase Inhibitors; Edema; Flavonoids; Granulocytes; Indomethacin; Kaempferols; Lipoxygenase Inhibitors; Male; Masoprocol; Mice; Mice, Inbred Strains; Quercetin; Umbelliferones | 1988 |
Anti-inflammatory and peripheral analgesic activity of esculetin in vivo.
Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and greater than 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect. Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Croton Oil; Drug Evaluation, Preclinical; Edema; Male; Mice; Mice, Inbred Strains; Peroxidases; Umbelliferones | 1988 |