esculetin and Arrhythmias--Cardiac

esculetin has been researched along with Arrhythmias--Cardiac* in 1 studies

Other Studies

1 other study(ies) available for esculetin and Arrhythmias--Cardiac

Article	Year
The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. Prostaglandins, leukotrienes, and medicine, 1987, Volume: 28, Issue:1 Platelet-activating factor (PAF), 10(-11) mol decreased the threshold of ouabain induced arrhythmia in guinea-pigs. The thresholds inducing premature ventricular beats and ventricular flutter were statistically significantly decreased by 27.4% and 15.6%, respectively. BM 13.177 (30 mg/kg), a thromboxane receptor antagonizing substance, and esculetin (1.2 mg/kg), a lipoxygenase inhibitor, abolished this arrhythmogenic effect of PAF. Acetylsalicylic acid (10 mg/kg) showed only a tendency to inhibit the PAF effect. These results suggest that PAF could play a role in cardiac arrhythmias under special conditions and it supports the hypothesis that PAF action is mediated by the release of leukotrienes and thromboxane. Topics: Animals; Arachidonic Acids; Arrhythmias, Cardiac; Aspirin; Fibrinolytic Agents; Guinea Pigs; Lipoxygenase Inhibitors; Ouabain; Platelet Activating Factor; Sulfonamides; Umbelliferones	1987

Article

Year

The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites.

Prostaglandins, leukotrienes, and medicine, 1987, Volume: 28, Issue:1

Platelet-activating factor (PAF), 10(-11) mol decreased the threshold of ouabain induced arrhythmia in guinea-pigs. The thresholds inducing premature ventricular beats and ventricular flutter were statistically significantly decreased by 27.4% and 15.6%, respectively. BM 13.177 (30 mg/kg), a thromboxane receptor antagonizing substance, and esculetin (1.2 mg/kg), a lipoxygenase inhibitor, abolished this arrhythmogenic effect of PAF. Acetylsalicylic acid (10 mg/kg) showed only a tendency to inhibit the PAF effect. These results suggest that PAF could play a role in cardiac arrhythmias under special conditions and it supports the hypothesis that PAF action is mediated by the release of leukotrienes and thromboxane.

Topics: Animals; Arachidonic Acids; Arrhythmias, Cardiac; Aspirin; Fibrinolytic Agents; Guinea Pigs; Lipoxygenase Inhibitors; Ouabain; Platelet Activating Factor; Sulfonamides; Umbelliferones

1987