Page last updated: 2024-10-26

erythrosine and Brain Hemorrhage, Cerebral, Traumatic

erythrosine has been researched along with Brain Hemorrhage, Cerebral, Traumatic in 1 studies

Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gu, Y1
Hua, Y1
Keep, RF1
Morgenstern, LB1
Xi, G1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Safety and Effectiveness Study of Deferoxamine and Xingnaojing Injection in Intracerebral Hemorrhage[NCT02367248]Phase 1/Phase 2180 participants (Anticipated)Interventional2015-03-31Recruiting
Futility Study of Deferoxamine in Intracerebral Hemorrhage[NCT01662895]Phase 242 participants (Actual)Interventional2013-03-18Terminated (stopped due to By DSMB on October 18, 2013 due to increased incidence of ARDS. See modified protocol [NCT02175225)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Patients Who Died During the 90-day Study Period

Mortality at any time from randomization through day-90 (NCT01662895)
Timeframe: 90 days

InterventionParticipants (Count of Participants)
Deferoxamine3
Normal Saline0

Number of Patients With Hypotension

(NCT01662895)
Timeframe: within 7 days or discharge

InterventionParticipants (Count of Participants)
Deferoxamine1
Normal Saline1

Number of Patients With New Visual or Auditory Changes

(NCT01662895)
Timeframe: within 7 days or discharge

InterventionParticipants (Count of Participants)
Deferoxamine0
Normal Saline1

Number of Patients With Serious Adverse Events

(NCT01662895)
Timeframe: 90 days

InterventionParticipants (Count of Participants)
Deferoxamine9
Normal Saline6

Number of Subjects With Acute Respiratory Distress Syndrome

(NCT01662895)
Timeframe: 90 days

InterventionParticipants (Count of Participants)
Deferoxamine6
Normal Saline0

Number of Subjects With Allergic/Anaphylactic Reaction

(NCT01662895)
Timeframe: within 7 days or discharge

InterventionParticipants (Count of Participants)
Deferoxamine0
Normal Saline0

Number of Subjects With Modified Rankin Scale (mRS) Score 0-2

"The primary outcome measure of efficacy is the modified Rankin Scale (mRS) score, dichotomized to define good functional outcome as mRS 0-2 at 90 days.~The minimum mRS score is 0 (i.e. no disability). The maximum score is 6 (i.e. dead)." (NCT01662895)
Timeframe: 90 days

InterventionParticipants (Count of Participants)
Deferoxamine6
Normal Saline10

Number of Subjects With mRS Score 0-3

The proportion of DFO- and placebo-treated subjects with mRS 0-3 vs. 4-6 at 90 days (NCT01662895)
Timeframe: 90 days

InterventionParticipants (Count of Participants)
Deferoxamine12
Normal Saline14

Other Studies

1 other study available for erythrosine and Brain Hemorrhage, Cerebral, Traumatic

ArticleYear
Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets.
    Stroke, 2009, Volume: 40, Issue:6

    Topics: Animals; Antidotes; Brain; Cell Death; Cerebral Hemorrhage, Traumatic; Deferoxamine; Ferritins; Fluo

2009
Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets.
    Stroke, 2009, Volume: 40, Issue:6

    Topics: Animals; Antidotes; Brain; Cell Death; Cerebral Hemorrhage, Traumatic; Deferoxamine; Ferritins; Fluo

2009
Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets.
    Stroke, 2009, Volume: 40, Issue:6

    Topics: Animals; Antidotes; Brain; Cell Death; Cerebral Hemorrhage, Traumatic; Deferoxamine; Ferritins; Fluo

2009
Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets.
    Stroke, 2009, Volume: 40, Issue:6

    Topics: Animals; Antidotes; Brain; Cell Death; Cerebral Hemorrhage, Traumatic; Deferoxamine; Ferritins; Fluo

2009