Compounds > erucylphospho-n-n-n-trimethylpropylammonium

erucylphospho-n-n-n-trimethylpropylammonium and Leukemia

erucylphospho-n-n-n-trimethylpropylammonium has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for erucylphospho-n-n-n-trimethylpropylammonium and Leukemia

Article	Year
Induction of apoptosis by erucylphospho-N,N,N-trimethylammonium is associated with changes in signal molecule expressionand location. Annals of the New York Academy of Sciences, 2003, Volume: 1010 At concentrations effecting apoptosis, the alkylphosphocholine ErPC3 induced increased expression of the Rb protein in breast cancer (MCF-7) and leukemia (SKW-3, AR-230) cell lines as well as hypophosphorylation (K-562, CMLT-1, DOHH-2) and fragmentation of Rb (BV-173, SKW-3) in leukemia cell lines. ErPC3 exerts at least part of its antineoplastic activity by apoptosis, and this chain of events comprises early changes in the lipid raft fraction of the cellular membrane as well as modulation of different signal molecules, such as Abl, Bcr-Abl (fusion protein), and Rb. Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Humans; K562 Cells; Leukemia; Organophosphates; Phosphorylation; Quaternary Ammonium Compounds; Retinoblastoma Protein; Signal Transduction	2003

Article

Year

Induction of apoptosis by erucylphospho-N,N,N-trimethylammonium is associated with changes in signal molecule expressionand location.

Annals of the New York Academy of Sciences, 2003, Volume: 1010

At concentrations effecting apoptosis, the alkylphosphocholine ErPC3 induced increased expression of the Rb protein in breast cancer (MCF-7) and leukemia (SKW-3, AR-230) cell lines as well as hypophosphorylation (K-562, CMLT-1, DOHH-2) and fragmentation of Rb (BV-173, SKW-3) in leukemia cell lines. ErPC3 exerts at least part of its antineoplastic activity by apoptosis, and this chain of events comprises early changes in the lipid raft fraction of the cellular membrane as well as modulation of different signal molecules, such as Abl, Bcr-Abl (fusion protein), and Rb.

Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Humans; K562 Cells; Leukemia; Organophosphates; Phosphorylation; Quaternary Ammonium Compounds; Retinoblastoma Protein; Signal Transduction

2003