eriocalyxin-b and Parkinson-Disease

Accumulating evidence indicates that microglia activation is associated with an increased risk for developing Parkinson's disease (PD). With the progressive and selective degeneration of dopaminergic (DA) neurons, proinflammatory cytokines are elevated in the substantia nigra (SN) of PD patients. Thus, anti-inflammation has become one of the therapeutic strategies of PD. Eriocalyxin B (EriB), a diterpenoid isolated from Isodoneriocalyx, was previously reported to have anti-inflammatory effects. MPTP mouse model and MPP

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Nucleus; Cytokines; Disease Models, Animal; Diterpenes; Dopaminergic Neurons; Inflammation Mediators; Mice, Inbred C57BL; Microglia; Motor Activity; NF-kappa B; Parkinson Disease; Phenotype; Phosphorylation; Protein Transport; Signal Transduction; Transcription Factor RelA