ergoline and Thrombosis

Topics: Animals; Anticoagulants; Aorta, Abdominal; Aspirin; Blood Vessel Prosthesis; Dipyridamole; Dogs; Ergolines; Female; Iliac Artery; Jugular Veins; Male; Papaverine; Premedication; Preoperative Care; Thrombosis; Transplantation, Autologous

The influence of dihydrogenated ergot alkaloids on vessels and blood platelets was studied in vitro and in vivo. At low concentrations they cause contraction of isolated vein strips via a stimulation of alpha-adrenoceptors, at higher concentrations they antagonize the action of noradrenaline on arteries and veins and inhibit the adrenaline-induced platelet aggregation in vitro. In volunteers, intravenous and subcutaneous administration of dihydroergotamine (Dihytamin) caused a decrease in blood volume of the capacitance vessels and inhibition of the adrenaline-potentiated platelet aggregation "ex vivo". The selective venoconstrictor and antiaggregating effects of dihydroergotamine are utilized in the postoperative prophylaxis of thrombosis.

Topics: Adrenergic alpha-Antagonists; Animals; Blood Volume; Dihydroergotamine; Epinephrine; Ergolines; Humans; Norepinephrine; Platelet Aggregation; Rabbits; Thrombosis; Vasoconstriction

Topics: Aged; Depression, Chemical; Ergolines; Female; Humans; Male; Middle Aged; Nicergoline; Platelet Aggregation; Postoperative Complications; Thrombosis

Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Ergolines; Nicotinic Acids; Platelet Adhesiveness; Rabbits; Thrombosis

Topics: Aspirin; Blood Coagulation Tests; Blood Platelets; Ergolines; Hemostasis; Humans; Platelet Adhesiveness; Thrombosis