ergoline and Substance-Related-Disorders

Topics: Amantadine; Antiparkinson Agents; Atrophy; Brain; Bromocriptine; Cognition; Dementia; Dreams; Drug Interactions; Ergolines; Humans; Levodopa; Libido; Memory; Parasympatholytics; Parkinson Disease; Receptors, Dopamine; Sexual Behavior; Substance-Related Disorders; Visual Perception

Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior. We found that this "priming" effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior. These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.

Topics: Animals; Behavior, Addictive; Behavior, Animal; Benzazepines; Caffeine; Cocaine; Dopamine Agonists; Ergolines; Male; Motor Activity; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Recurrence; Reinforcement, Psychology; Substance-Related Disorders; Tetrahydronaphthalenes

Topics: Amphetamine; Behavior; Canada; Cannabis; Chemical Warfare Agents; Ergolines; Glycolates; Hallucinogens; Humans; Japan; Lysergic Acid Diethylamide; Narcotics; Psychopharmacology; Psychoses, Substance-Induced; Stimulation, Chemical; Substance-Related Disorders; Toxicology; United States