ergoline and Oligomenorrhea

Topics: Adult; Cabergoline; Choristoma; Diagnosis, Differential; Ergolines; Female; Hormone Antagonists; Humans; Hyperprolactinemia; Magnetic Resonance Imaging; Oligomenorrhea; Pituitary Diseases; Pituitary Gland, Posterior; Prolactin; Recurrence; Treatment Outcome

Eighteen hyperprolactinaemic patients were orally treated for up to 16 months with pergolide mesylate, a new potent long-lasting dopaminergic ergot derivative. In all cases, Prl normalization (less than 25 ng/ml) was achieved at a once-a-day dose of 50-300 micrograms. All women recovered and/or exhibited normal menstrual function. Among the 6 women wishing to become pregnant, 4 of them conceived within 4 months; there were other causes for infertility than hyperprolactinaemia in the 2 other couples. A macroprolactinoma man experienced important improvement in well-being as well as objective regression of his visual fields defect. This suggests a shrinkage effect of pergolide on the tumoural process. Another man regained normal potency and normal testosterone within 2 weeks. While 10 patients were completely free of any side effect, 7 experienced transiently mild gastro-intestinal side effects or postural hypotension. Only one patient discontinued her treatment because of dizziness. The present study demonstrates the high potency, the good tolerance and the excellent efficacy of pergolide in the treatment of hyperprolactinaemia.

Topics: Adolescent; Adult; Amenorrhea; Dose-Response Relationship, Drug; Ergolines; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Middle Aged; Oligomenorrhea; Pergolide; Pituitary Neoplasms; Prolactin; Time Factors

This is a report about 20 sterile women in whom the amenorrhoea or oligomenorrhoea was accompanied by hyperprolactinaemia. Parlodel, Lysenyl, and Deprenon were used for treatment. The therapy was followed by pregnancy of 70 per cent of the women.

Topics: Amenorrhea; Bromocriptine; Ergolines; Female; Galactorrhea; Humans; Infertility, Female; Lisuride; Oligomenorrhea; Pregnancy; Prolactin

19 women with anovulation after discontinuing oral contraceptive agents and with normal plasma-prolactin concentrations were treated with bromocriptine. Ovulation and menstruation were restored in 9 of the 13 amenorrhoeic and 5 of the 6 oligomenorrhoeic patients. The success-rate (74%) indicates that bromocriptine is an effective treatment for post-pill anovulation in normoprolactinaemic women.. The therapeutic efficacy of bromocriptine in the treatment of anovulation was assessed in 19 women who failed to return to fertility following discontinuation of oral contraceptive (OC) use. Plasma concentrations of prolactin were normal. Treatment with bromocriptine restored ovulation and menstruation in 9 of the 13 amenorrheic patients and in 5 of 6 oligomenorrheic women. Given the high success rate (74%), it is concluded that bromocriptine is an effective treatment for postpill anovulation in women with normal prolactin levels.

Topics: Adolescent; Adult; Amenorrhea; Anovulation; Bromocriptine; Contraceptives, Oral; Drug Evaluation; Ergolines; Female; Follow-Up Studies; Humans; Menstruation Disturbances; Oligomenorrhea; Prolactin