ergoline and Muscle-Cramp

The effectiveness of five different serotonin antagonists in the prevention of migraine was compared in 290 patients followed for periods of up to three years. Methysergide 3-6 mg. daily was most effective, with 20% of treated patients becoming headache-free and a further 44% remaining more than "half improved." The corresponding figures for BC105 were 10% and 40%, respectively.The results with BC105 were significantly better than those with placebo (P<0.02). The total improvement rates with methdilazine (45%) and cyproheptadine (43%) were better than those with placebo (32%) but did not achieve statistical significance. A new preparation, methylergol carbamide maleate, which is chemically related to methysergide, did not give better results than placebo.

Topics: Clinical Trials as Topic; Cyproheptadine; Ergolines; Female; Histamine H1 Antagonists; Humans; Male; Methysergide; Migraine Disorders; Muscle Cramp; Nausea; Phenothiazines; Placebos; Pyrrolidines; Serotonin Antagonists; Thiophenes