ergoline and Memory-Disorders

Topics: Aged; Amantadine; Animals; Brain; Cats; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Ergolines; gamma-Aminobutyric Acid; Humans; Lisuride; Memory Disorders; Mice; Pantothenic Acid

The potential antagonism of a single oral dose of RU 41 656 (10 mg) on the memory and attention disturbances induced by oral administration of triazolam (0.25 mg) have been investigated in a 3-period, placebo controlled, double blind, cross-over study involving 12 healthy young volunteers. The effects of the compounds were evaluated by objective tests (Buschke selective reminding test, CFF, simple reaction time, tapping, arithmetical calculation) and subjective measurements (visual analogue scale, side effects questionnaire). Measurements were taken before treatment and 2, 4 and 7 h after RU 41 656 intake. Triazolam caused anterograde amnesia as already described with other benzodiazepine with few sedative effects at this dosage. Under the experimental conditions of the trial, RU 41 656 failed to counteract the memory deficits induced by triazolam.

Topics: Adult; Attention; Cognition Disorders; Double-Blind Method; Emotions; Ergolines; Flicker Fusion; Humans; Male; Memory; Memory Disorders; Psychomotor Performance; Reaction Time; Receptors, Dopamine; Receptors, Dopamine D2; Reference Values; Triazolam

Topics: Aged; Amantadine; Animals; Brain; Cats; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Ergolines; gamma-Aminobutyric Acid; Humans; Lisuride; Memory Disorders; Mice; Pantothenic Acid

To determine the effect of non-selective 5-HT2C antagonist mesulergine and 5-HT2C agonist mCPP (metachlorophenylpiperazine) on learning acquisition (LA), short-term memory (STM) and long-term memory (LTM).. Experimental study.. Department of Biochemistry, University of Karachi, from December 2009 to June 2010.. Twenty-four male albino Wistar rats were used in this study. The agonist and antagonist (mCPP and mesulergine) were injected intraperitoneally at a dose 3.0 mg/kg in volumes of 1 ml/kg. Control animals were injected with saline (1 ml/kg). Animals were randomly divided into four groups (n=6). 1st being control group, 2nd being mCPP injected group, 3rd being mesulergine injected group and 4th group being injected with both mesulergine and mCPP. Behavioural activities of rats were monitored after 30 minutes of injection. For assessment of memory functions, water maze apparatus was used.. Administration of mCPP impaired STM, LTM and LA of rats. Mesulergine injected rats exhibited no alteration in memory functions. However, when it was injected with mCPP then there were no memory deficits induced by mCPP.. Ability of 5-HT2C receptor antagonist mesulergine to block the memory impairment effect of mCPP indicated an important regulatory role of 5-HT2C receptors in cognitive processes.

Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Ergolines; Male; Maze Learning; Memory Disorders; Memory, Long-Term; Memory, Short-Term; Piperazines; Random Allocation; Rats; Rats, Wistar; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists

Topics: Adult; Aged; Arteriosclerosis; Blood Pressure; Cerebrovascular Disorders; Ergolines; Evaluation Studies as Topic; Female; Glomerulonephritis; Heart Block; Humans; Hypertension; Intracranial Arteriosclerosis; Intracranial Embolism and Thrombosis; Male; Memory Disorders; Middle Aged; Vascular Diseases; Vascular Headaches; Vision Disorders

Topics: Aged; Amnesia; Brain; Ergolines; Humans; Male; Memory Disorders; Memory, Short-Term; Syndrome