ergoline has been researched along with Leukemia-L5178* in 2 studies
2 other study(ies) available for ergoline and Leukemia-L5178
| Article | Year |
|---|---|
Clavines as antitumor agents; 2. Natural 8-hydroxymethyl-ergoline type clavines and their derivatives.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Cells, Cultured; Chemical Phenomena; Chemistry; Ergolines; Leukemia L5178; Mice | 1986 |
Clavines. New antibiotics with cytostatic activity.
The cytostatic potentials of ten ergolines were determined in the L5178y mouse lymphoma cell system; six of them belong to the clavines (agroclavine, 1-propyl-agroclavine, 1-propyl-festuclavine, 1-allyl-festuclavine, 6-cyano-6-nor-festuclavine and 1-hydroxymethyl-festuclavine) and four to the lysergic acid derivatives (methylergometrine, lysergic acid amide, isolysergic acid amide and lysergic acid diethylamide). It is shown that agroclavine (ED50: 3.9 microM), 1-propyl-agroclavine (3.5 microM), 1-propylfestuclavine (4.3 microM) and 1-allyl-festuclavine (4.3 microM) are potent cytostatic agents. Up to 2 X ED50 concentration the inhibitory effect was completely reversible. Incorporation studies suggested that the compounds inhibit DNA synthesis; this assumption was also supported by the findings which revealed that after incubation with these clavines, the cells showed slight 'unbalanced growth'. 6-Cyano-6-nor-festuclavine was less inhibitory (ED50 11.8 microM). 1-Hydroxymethyl-festuclavine and all lysergic acid derivatives tested were without any detectable activity. Topics: Animals; Antibiotics, Antineoplastic; Cell Survival; Cells, Cultured; DNA; Ergolines; Leukemia L5178; Mice; RNA; Structure-Activity Relationship | 1984 |