ergoline and Intracranial-Arteriosclerosis

Topics: Adult; Aged; Arteriosclerosis; Attention; Clinical Trials as Topic; Drug Evaluation; Ergolines; Female; Headache; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Nicotinic Acids; Pain; Raynaud Disease

Topics: Adult; Aged; Cerebrovascular Circulation; Clinical Trials as Topic; Drug Evaluation; Ergolines; Female; Hemodynamics; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Nicotinic Acids

It has been found that the drug sermion (nicergoline)--a synthetic ergot alkaloid with alpha-adrenoblocking action--produces a pronounced vasoactive (spasmolytic) effect in the elderly patients suffering of initial atherosclerotic encephalopathy. A course of sermion treatment improves, via its effect on the brain and lower extremity vessels, the flow in most involved vascular regions. High concentrations of the drug after intravenous administration of 4 mg of sermion (nicergoline) result in a rise of the sympathetic vascular tone, high adrenoblocking action.

Topics: Administration, Oral; Aged; Cerebrovascular Circulation; Drug Evaluation; Ergolines; Hemodynamics; Humans; Injections, Intravenous; Intracranial Arteriosclerosis; Middle Aged; Nicergoline; Time Factors

The authors report results of a clinico-physiological study of the efficacy of a vasoactive agent sermion in patients with initial atherosclerotic encephalopathy indicating a positive effect of course treatment with this agent on the main clinical manifestations of the disease, pulse blood filling, bioelectric activity of the brain, psychomotor rate, mental working capacity, mnemonic function. Considering the established age-related differences in the efficacy of the agent, it is expedient to recommend sermion for long-term employment in the elderly. One should be cautious in instituting the drug in persons suffering of raised intraocular pressure.

Topics: Aged; Drug Evaluation; Electroencephalography; Ergolines; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Nicergoline; Psychological Tests; Tablets; Time Factors

Topics: Adult; Brain; Brain Ischemia; Drug Evaluation; Ergolines; Humans; Injections, Intravenous; Intracranial Arteriosclerosis; Middle Aged; Nicergoline; Plethysmography, Impedance; Tablets; Time Factors

Topics: Aged; Cerebral Angiography; Cerebrovascular Circulation; Ergolines; Female; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Nicergoline

Topics: Adult; Aged; Cerebral Angiography; Cerebrovascular Circulation; Cerebrovascular Disorders; Electrocardiography; Ergolines; Female; Humans; Intracranial Arteriosclerosis; Intracranial Embolism and Thrombosis; Ischemic Attack, Transient; Male; Middle Aged; Vinca Alkaloids

Topics: Adult; Aged; Arteriosclerosis; Blood Pressure; Cerebrovascular Disorders; Ergolines; Evaluation Studies as Topic; Female; Glomerulonephritis; Heart Block; Humans; Hypertension; Intracranial Arteriosclerosis; Intracranial Embolism and Thrombosis; Male; Memory Disorders; Middle Aged; Vascular Diseases; Vascular Headaches; Vision Disorders

Topics: Aged; Arterial Occlusive Diseases; Cerebrovascular Disorders; Ergolines; Female; Humans; Intracranial Arteriosclerosis; Ischemic Attack, Transient; Leg; Male; Middle Aged; Vasodilator Agents

Topics: Adult; Aged; Blood Pressure; Brain; Cerebrovascular Circulation; Ergolines; Female; Glucose; Hemodynamics; Humans; Hypertension; Intracranial Arteriosclerosis; Male; Middle Aged; Oxygen Consumption