ergoline and Acute-Disease

Topics: Acute Disease; Alkaloids; Amines; Amphetamine; Antidotes; Atropa belladonna; Cannabis; Ergolines; Hallucinogens; Humans; Indoles; Lysergic Acid Diethylamide; Parasympatholytics; Phencyclidine; Phenethylamines; Plants, Medicinal; Plants, Toxic; Psilocybin; Toxicology

Acute cerebral ischaemia may take considerable advantages of an adequate intensive therapy associated with a specific treatment of cerebral oedemas, especially in terms of mortality-rate reduction. Moreover, target treatment of acute cerebral ischaemia may produce excellent results in severe cases selected by means of EEG-chronospectrography. Double-blind, randomized comparison between nicergolin and buflomedil especialls showed that the latter reduces mortality three times as much as nicergolin, and leads to a 200% increment in the complete recovery of the "functio laesa", limited to those cases, which showed an appreciable improvement following EEG-chronospectrographical survey.

Topics: Acute Disease; Aged; Brain Ischemia; Cerebrovascular Circulation; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Electroencephalography; Ergolines; Female; Humans; Male; Middle Aged; Nicergoline; Pyrrolidines; Random Allocation

To review clinical presentation, management and outcomes following different therapies in patients with pituitary apoplexy.. Retrospective analysis of case-records of patients with classical pituitary apoplexy treated in our hospitals between 1983-2004.. Forty-five patients (28 men; mean age 49 years, range 16-72 years) were identified. Only 8 (18%) were known to have pituitary adenomas at presentation. Thirty-four (81%) patients had hypopituitarism at presentation. CT and MRI identified pituitary apoplexy in 28% and 91% cases, respectively. Twenty-seven (60%) patients underwent surgical decompression, whilst 18 (40%) were managed conservatively. Median time from presentation to surgery was 6 days (range 1-121 days). Patients with visual field defects were more likely than those without these signs to be managed surgically (p = 0.01). Complete or near-complete resolution occurred in 93% (13/14), 94% (15/16) and 93% (13/14) of the surgically treated patients with reduced visual acuity, visual field deficit and ocular palsy, respectively. All patients with reduced visual acuity (4/4), visual field deficit (4/4) and ocular palsy (8/8) in the conservative group had complete or near-complete recovery. Only 5 (19%) patients in the surgical group and 2 (11%) in the conservative group had normal pituitary function at follow up. One (4%) patient in the surgical group and 4 (22%) in the conservative group had a recurrence of pituitary adenoma.. This large series suggests that the patients with classical pituitary apoplexy, who are without neuro-ophthalmic signs or exhibit mild and non-progressive signs, can be managed conservatively in the acute stage.

Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Cabergoline; Combined Modality Therapy; Decompression, Surgical; Ergolines; Female; Humans; Hypopituitarism; Magnetic Resonance Imaging; Male; Middle Aged; Pituitary Apoplexy; Pituitary Gland; Pituitary Neoplasms; Retrospective Studies; Tomography, X-Ray Computed; Treatment Outcome; Vision Disorders

A beneficial stabilizing effect of nicergoline on EEG recorded from cortex and some subcortical structures was established in cats under acute normal and anoxic conditions.

Topics: Acute Disease; Animals; Asphyxia; Brain; Cats; Electroencephalography; Ergolines; Hypoxia, Brain; Male; Nicergoline; Reference Values

Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acute Disease; Animals; Benzazepines; Biperiden; Cebus; Drug Interactions; Dyskinesia, Drug-Induced; Ergolines; Male; Quinpirole; Raclopride; Receptors, Dopamine; Salicylamides

Topics: Acute Disease; Adrenergic alpha-Antagonists; Aged; Drug Evaluation; Ergolines; Ergoloid Mesylates; Female; Hemiplegia; Humans; Intelligence; Male; Middle Aged; Motor Skills; Nicotinic Acids; Time Factors