erdafitinib and Adenocarcinoma

Despite advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains among the deadliest malignancies, with a poor prognosis at time of diagnosis. Research in PDAC has suggested that adaptive signaling in the tumor microenvironment may promote tumor proliferation and survival. Several FGFR fusion genes-specifically FGFR2-are involved with the creation and progression of cancer. These mutations are found in a variety of cancer types. This report presents a unique case of a young patient with stage IV PDAC with a known FGFR2 fusion. This molecular alteration afforded a remarkable response to FGFR inhibitor therapy, erdafitinib, after the patient experienced disease progression on multiple chemotherapy regimens.

Topics: Adenocarcinoma; Carcinoma, Pancreatic Ductal; Humans; Pancreatic Neoplasms; Pyrazoles; Quinoxalines; Receptor, Fibroblast Growth Factor, Type 2; Tumor Microenvironment

We report a case of a frail 68-year-old woman with stage 4 pancreatic carcinoma harbouring a fibroblastic growth factor receptor 2 (

Topics: Adenocarcinoma; Aged; Carrier Proteins; Female; Humans; Mutation; Pancreatic Neoplasms; Pyrazoles; Quinoxalines; Receptor, Fibroblast Growth Factor, Type 2; Tumor Suppressor Proteins

Topics: Adenocarcinoma; Fluorescein Angiography; Fundus Oculi; Humans; Pyrazoles; Quinoxalines; Receptors, Fibroblast Growth Factor; Retina; Retinal Diseases; Stomach Neoplasms; Tomography, Optical Coherence; Visual Acuity