erbstatin and Neoplasms--Nerve-Tissue

erbstatin has been researched along with Neoplasms--Nerve-Tissue* in 1 studies

Other Studies

1 other study(ies) available for erbstatin and Neoplasms--Nerve-Tissue

Article	Year
[Inhibitors for protein tyrosine kinases, erbstatin, genistein and herbimycin A, induce differentiation of human neural tumor cell lines]. Nihon geka hokan. Archiv fur japanische Chirurgie, 1991, Mar-01, Volume: 60, Issue:2 Recent reports suggest that protein phosphorylation is involved in neural differentiation. We have found that specific inhibitors of protein phosphorylation at tyrosine residues, Erbstatin, Genistein, Herbimycin A, effectively induce neural differentiation in a human neuroblastoma cell line SK-N-DZ and a human medulloblastoma cell line Med-3, as indicated by the marked increase in the number of neurites/cell and in the expression of neurofilaments (160 k) detected by immunohistochemical studies. Possible involvement of protein phosphorylation at tyrosine residues in the differentiation of neural tumor cells was stressed. Topics: Antibiotics, Antineoplastic; Benzoquinones; Cell Differentiation; Genistein; Humans; Hydroquinones; Immunohistochemistry; Isoflavones; Lactams, Macrocyclic; Neoplasms, Nerve Tissue; Neurofilament Proteins; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tumor Cells, Cultured	1991

Article

Year

[Inhibitors for protein tyrosine kinases, erbstatin, genistein and herbimycin A, induce differentiation of human neural tumor cell lines].

Nihon geka hokan. Archiv fur japanische Chirurgie, 1991, Mar-01, Volume: 60, Issue:2

Recent reports suggest that protein phosphorylation is involved in neural differentiation. We have found that specific inhibitors of protein phosphorylation at tyrosine residues, Erbstatin, Genistein, Herbimycin A, effectively induce neural differentiation in a human neuroblastoma cell line SK-N-DZ and a human medulloblastoma cell line Med-3, as indicated by the marked increase in the number of neurites/cell and in the expression of neurofilaments (160 k) detected by immunohistochemical studies. Possible involvement of protein phosphorylation at tyrosine residues in the differentiation of neural tumor cells was stressed.

Topics: Antibiotics, Antineoplastic; Benzoquinones; Cell Differentiation; Genistein; Humans; Hydroquinones; Immunohistochemistry; Isoflavones; Lactams, Macrocyclic; Neoplasms, Nerve Tissue; Neurofilament Proteins; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tumor Cells, Cultured

1991