erastin and Swine-Diseases

Porcine epidemic diarrhea virus (PEDV), an intestinal pathogenic coronavirus, has caused significant economic losses to the swine industry worldwide. At present, there are several treatment methods, but there is still a lack of clinically effective targeted drugs, new antiviral mechanisms and drugs need to be explored.. In this study, we established a model of erastin versus ferrostatin-1 treatment of Vero cells, and then detected virus proliferation and gene expression by RT-qPCR through PEDV infection experiments.. We demonstrated for the first time that erastin significantly inhibited the replication of PEDV upon entry into cells; Vero treated with erastin significantly regulated the expression of three genes,. Since

Topics: Animals; Chlorocebus aethiops; Coronavirus Infections; NF-E2-Related Factor 2; Piperazines; Porcine epidemic diarrhea virus; Swine; Swine Diseases; Vero Cells; Virus Replication