erastin has been researched along with Peripheral-Nerve-Injuries* in 1 studies
1 other study(ies) available for erastin and Peripheral-Nerve-Injuries
| Article | Year |
|---|---|
Overexpression of c-Jun inhibits erastin-induced ferroptosis in Schwann cells and promotes repair of facial nerve function.
Myelin undergoes various changes after nerve injury, and c-Jun has a close relationship with Schwann cells (SCs). However, it remains unclear whether c-Jun can be involved in nerve repair by regulating ferroptosis. To explore this, we first set up a facial nerve injury model and detected the changes of ferroptosis-related proteins and c-Jun by immunofluorescence and Western blot. Then, we cultured RSC 96 and pSCs, and studied the potential regulatory relationships by a combination of experimental methods such as CCK-8, ELISA, immunofluorescence, qRT-PCR, Western blot and viral transfection. Finally, we corroborated the role of c-Jun through animal experiments. Our experiments revealed that ferroptosis occurs after facial nerve injury. Erastin decreased GPX4, c-Jun proteins and GSH content, while PTGS2, NRF2, HO-1 proteins, MDA, Fe Topics: Animals; Facial Nerve; Facial Nerve Injuries; Ferroptosis; NF-E2-Related Factor 2; Peripheral Nerve Injuries; Piperazines; Schwann Cells; Signal Transduction | 2022 |