er-086526 and Tumor-Lysis-Syndrome

Tumor lysis syndrome (TLS) is a complication of cancer treatment that requires urgent intervention. It is extremely rare in the treatment of soft tissue sarcoma (STS) of the limbs or trunk, and there are currently no reports of TLS occurrence from eribulin therapy. We report the case of a 78-year-old woman with an undiffer-entiated pleomorphic sarcoma on the right buttock. We initiated chemotherapy with intravenous eribulin mesylate. Deterioration of renal function, mild hyperkalemia, hyperuricemia, hypocalcemia, and hyperphos-phatemia were confirmed on examination, suggesting the presence of TLS. We present an extremely rare case of TLS from eribulin for STS.

Topics: Aged; Antineoplastic Agents; Buttocks; Fatal Outcome; Female; Furans; Humans; Ketones; Positron Emission Tomography Computed Tomography; Sarcoma; Soft Tissue Neoplasms; Tumor Lysis Syndrome

A middle-aged woman with a history of leiomyosarcoma of the uterus treated with surgery and adjuvant chemotherapy suffered a bulky metastatic recurrence 1 year later. She elected treatment with palliative eribulin, presenting with acute renal failure and electrolyte abnormalities consistent with tumour lysis syndrome on cycle 1 day 8. Despite aggressive supportive care and treatment including intravenous hydration, bicarbonate and rasburicase, she continued to decline, ultimately foregoing haemodialysis in favour of palliative care and passed away in the hospital.

Topics: Acute Kidney Injury; Antimitotic Agents; Fatal Outcome; Female; Furans; Humans; Ketones; Leiomyosarcoma; Liver Neoplasms; Middle Aged; Tumor Lysis Syndrome; Uterine Neoplasms