epz004777 and Neoplasms

epz004777 has been researched along with Neoplasms* in 1 studies

Reviews

1 review(s) available for epz004777 and Neoplasms

ArticleYear
Oncoepigenomics: making histone lysine methylation count.
    European journal of medicinal chemistry, 2012, Volume: 56

    Increasing studies show that methylation of histone lysine residues is implicated in the development and progression of varying disease states such as schizophrenia, diabetes, and multiple human cancers. Targeting the specific enzymes responsible for these processes has fueled global investigation into the understanding and correction of epigenetic pathology. This review aims to assemble a timely account of the current progress against chromatin-modifying histone lysine methyltransferases (KMTs) and demethylases (KDMs) to inform ongoing and future efforts into this promising field. In particular, we report on their role in tumor growth and progression and the development of small molecules that modulate these enzymes.

    Topics: Animals; Epigenomics; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms

2012