epz-6438 and Colitis

epz-6438 has been researched along with Colitis* in 1 studies

Other Studies

1 other study(ies) available for epz-6438 and Colitis

ArticleYear
Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration.
    Cell research, 2021, Volume: 31, Issue:3

    The capacity of 3D organoids to mimic physiological tissue organization and functionality has provided an invaluable tool to model development and disease in vitro. However, conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives. Here, we established a novel intestinal organoid culture system composed of 8 components, mainly including VPA, EPZ6438, LDN193189, and R-Spondin 1 conditioned medium, which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury; therefore, these organoids were designated hyperplastic intestinal organoids (Hyper-organoids). Single-cell RNA sequencing identified different regenerative stem cell populations in our Hyper-organoids that shared molecular features with in vivo injury-responsive Lgr5

    Topics: Animals; Benzamides; Biphenyl Compounds; Cells, Cultured; Colitis; Culture Media, Conditioned; Dextran Sulfate; Disease Models, Animal; Female; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Organoids; Pyridones; Radiation Injuries; Regeneration; Signal Transduction; Stem Cells; Tissue Culture Techniques; Treatment Outcome; Valproic Acid

2021