epsilon-viniferin has been researched along with Diarrhea* in 1 studies
1 other study(ies) available for epsilon-viniferin and Diarrhea
| Article | Year |
|---|---|
Resveratrol dimer trans-ε-viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel.
We previously identified, by a natural-product screen, resveratrol oligomers as inhibitors of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Here, we report the resveratrol dimer trans-ε-viniferin (TV) and tetramer r-2-viniferin (RV) as inhibitors of the intestinal calcium-activated chloride channel (CaCC) and demonstrate their antisecretory efficacy in a neonatal mouse model of rotaviral diarrhea. Short-circuit measurements show inhibition of CaCC current in the human colonic cell line HT-29 by TV and RV with IC Topics: Animals; Benzofurans; Chloride Channels; Diarrhea; HT29 Cells; Humans; Intestines; Male; Mice, Inbred C57BL; Resveratrol; Rotavirus; Rotavirus Infections; Stilbenes | 2018 |