epothilone-a and Autistic-Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, characterized by impaired social communication, abnormal repetitive behaviors and restricted interests and/or sensory behaviors. It has been widely accepted that ASD involves a complex interplay of both genetic and environmental risk factors. Existing medications are only symptomatic treatments, there are no effective treatments that can improve these core social behavior deficits. Recent studies indicated that synaptic development and abnormal myelination are linked to the pathogenesis of ASD. The stable tubule only polypeptide (STOP) protein, also known as microtubule-associated protein 6, plays an important role in neuronal development and synaptic plasticity. Our previous studies showed that STOP protein was significantly reduced in the plasma of autistic subjects and in the cortex of BTBR T

Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Dimethyl Sulfoxide; Disease Models, Animal; Epothilones; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Myelin Proteins; Social Behavior