epoetin-alfa and Hypotension

epoetin-alfa has been researched along with Hypotension* in 2 studies

Other Studies

2 other study(ies) available for epoetin-alfa and Hypotension

Article	Year
Intraoperative Blood Loss Among Jehovah's Witnesses in Spinal Deformity Surgery: A Report of 5 Cases. Journal of the South Carolina Medical Association (1975), 2015, Volume: 111, Issue:2 Topics: Adolescent; Anesthesia, General; Blood Loss, Surgical; Blood Transfusion, Autologous; Bloodless Medical and Surgical Procedures; Child; Epoetin Alfa; Female; Hematinics; Humans; Hypotension; Jehovah's Witnesses; Retrospective Studies; Scoliosis	2015
Systemic and renal haemodynamic changes in renal schemia/reperfusion injury: impact of erythropoietin. Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:11 The objective of this study was to investigate the effects of erythropoietin (EPO) on systemic and renal hemodynamics in a rat model of renal ischemic/reperfusion (I/R) injury. We used 30 male Sprague-Dawley rats distributed among the following 3 groups (10 rats per group): (i) the sham-operated group, (ii) the control group (I/R injury only), and (iii) the EPO-treated group (I/R injury with 1500 U EPO·(kg body mass)⁻¹ on day 0, and 500 U·kg⁻¹ on days 2 and 4 after ischemia). Renal function, arterial blood pressure (ABP), renal plasma flow (RPF), renal blood flow (RBF), and renal vascular resistance (RVR) were measured on days 1, 2, and 7 after ischemia. The expression of endothelial NO synthase (eNOS) and histopathology of kidney were evaluated on day 7. The contractility of aortic strips was recorded from the different groups. The results show that renal function and histopathology were significantly improved after treatment with EPO. Compared with the control group, the EPO-treated group showed a significant increase in RPF, RBF, haematocrite, ABP, eNOS expression, and a decrease in RVR (p < 0.05).The response of aortic strips to the relaxant effect of acetylcholine was improved in the EPO-treated group. In conclusion, treatment with EPO improves renal function and renal haemodynamics in renal I/R injury, and causes significant rise of ABP and haematocrite value. Topics: Animals; Aorta, Thoracic; Drug Resistance; Enzyme Induction; Epoetin Alfa; Erythropoietin; Hematinics; Hemodynamics; Hypotension; Ischemia; Kidney; Male; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Protective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Renal Circulation; Reperfusion Injury; Vascular Resistance; Vasodilation; Vasodilator Agents	2012

Article

Year

Intraoperative Blood Loss Among Jehovah's Witnesses in Spinal Deformity Surgery: A Report of 5 Cases.

Journal of the South Carolina Medical Association (1975), 2015, Volume: 111, Issue:2

Topics: Adolescent; Anesthesia, General; Blood Loss, Surgical; Blood Transfusion, Autologous; Bloodless Medical and Surgical Procedures; Child; Epoetin Alfa; Female; Hematinics; Humans; Hypotension; Jehovah's Witnesses; Retrospective Studies; Scoliosis

2015

Systemic and renal haemodynamic changes in renal schemia/reperfusion injury: impact of erythropoietin.

Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:11

The objective of this study was to investigate the effects of erythropoietin (EPO) on systemic and renal hemodynamics in a rat model of renal ischemic/reperfusion (I/R) injury. We used 30 male Sprague-Dawley rats distributed among the following 3 groups (10 rats per group): (i) the sham-operated group, (ii) the control group (I/R injury only), and (iii) the EPO-treated group (I/R injury with 1500 U EPO·(kg body mass)⁻¹ on day 0, and 500 U·kg⁻¹ on days 2 and 4 after ischemia). Renal function, arterial blood pressure (ABP), renal plasma flow (RPF), renal blood flow (RBF), and renal vascular resistance (RVR) were measured on days 1, 2, and 7 after ischemia. The expression of endothelial NO synthase (eNOS) and histopathology of kidney were evaluated on day 7. The contractility of aortic strips was recorded from the different groups. The results show that renal function and histopathology were significantly improved after treatment with EPO. Compared with the control group, the EPO-treated group showed a significant increase in RPF, RBF, haematocrite, ABP, eNOS expression, and a decrease in RVR (p < 0.05).The response of aortic strips to the relaxant effect of acetylcholine was improved in the EPO-treated group. In conclusion, treatment with EPO improves renal function and renal haemodynamics in renal I/R injury, and causes significant rise of ABP and haematocrite value.

Topics: Animals; Aorta, Thoracic; Drug Resistance; Enzyme Induction; Epoetin Alfa; Erythropoietin; Hematinics; Hemodynamics; Hypotension; Ischemia; Kidney; Male; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Protective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Renal Circulation; Reperfusion Injury; Vascular Resistance; Vasodilation; Vasodilator Agents

2012