epirizole has been researched along with Gastric Ulcer in 16 studies
Epirizole: 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine. A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have investigated the endogenous levels of duodenal calcitonin gene-related peptide- (CGRP) and Substance P- (SP) like immunoreactivity (li) following the induction of duodenal ulcers in rats." | 7.68 | Decrease of duodenal calcitonin gene-related peptide- and substance P-like immunoreactivity in rat duodenal ulcers. ( Evangelista, S; Mantellini, P; Renzi, D; Surrenti, C, 1991) |
| " Acutely induced gastric ulcers or erosions such as Shay ulcers, water-immersion stress-, indomethacin-, aspirin-, or prednisolone-induced erosions were all markedly inhibited by oral or intraduodenal administration of 10-100 mg/kg of omeprazole." | 7.67 | Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984) |
| "The purpose of these studies was to determine the role played by endogenous prostaglandins in the development of gastric ulcers produced by indomethacin, and of duodenal ulcers produced by mepirizole in rats." | 7.67 | Prostaglandin deficiency by itself is not the cause of mepirizole-induced duodenal ulcers in rats. ( Jacobson, ED; Joffe, SN; Robert, A; Tabata, K, 1987) |
| "Duodenal ulcers were produced in rats following either an oral or parenteral administration of 200 mg/kg of mepirizole, a nonsteroidal antiinflammatory agent." | 7.66 | Mepirizole-induced duodenal ulcers in rats and their pathogenesis. ( Inoo, H; Ishihara, Y; Okabe, S; Tanaka, H, 1982) |
| ") inhibited mepirizole-induced duodenal ulcers." | 3.69 | YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats. ( Akuzawa, S; Ito, H; Kamato, T; Kobayashi, A; Miyata, K; Nagakura, Y; Nishida, A; Takinami, Y; Yamano, M; Yuki, H, 1994) |
| "We have investigated the endogenous levels of duodenal calcitonin gene-related peptide- (CGRP) and Substance P- (SP) like immunoreactivity (li) following the induction of duodenal ulcers in rats." | 3.68 | Decrease of duodenal calcitonin gene-related peptide- and substance P-like immunoreactivity in rat duodenal ulcers. ( Evangelista, S; Mantellini, P; Renzi, D; Surrenti, C, 1991) |
| " Z-103 given orally prevented development of gastric lesions induced by water immersion stress, histamine, HCl-aspirin, HCl-ethanol and also duodenal ulcers induced by mepirizole in a dose-dependent manner." | 3.68 | [Studies on anti-ulcer effects of a new compound, zinc L-carnosine (Z-103)]. ( Aita, H; Hori, Y; Morita, H; Okabe, S; Seiki, M; Soeda, M; Tagashira, E; Tanaka, Y; Ueki, S; Yoneta, T, 1990) |
| " Acutely induced gastric ulcers or erosions such as Shay ulcers, water-immersion stress-, indomethacin-, aspirin-, or prednisolone-induced erosions were all markedly inhibited by oral or intraduodenal administration of 10-100 mg/kg of omeprazole." | 3.67 | Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984) |
| ") inhibited restraint and water-immersion-induced stress, ulcers, indometacin- and absolute ethanol-induced gastric ulcers and mepirizole-induced duodenal ulcers in rats in a dose-dependent manner." | 3.67 | Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats. ( Bickel, M; Goto, M; Hayashi, S; Herling, AW; Sakurai, M; Tanaka, T, 1989) |
| "The purpose of these studies was to determine the role played by endogenous prostaglandins in the development of gastric ulcers produced by indomethacin, and of duodenal ulcers produced by mepirizole in rats." | 3.67 | Prostaglandin deficiency by itself is not the cause of mepirizole-induced duodenal ulcers in rats. ( Jacobson, ED; Joffe, SN; Robert, A; Tabata, K, 1987) |
| "Duodenal ulcers were produced in rats following either an oral or parenteral administration of 200 mg/kg of mepirizole, a nonsteroidal antiinflammatory agent." | 3.66 | Mepirizole-induced duodenal ulcers in rats and their pathogenesis. ( Inoo, H; Ishihara, Y; Okabe, S; Tanaka, H, 1982) |
| "Indomethacin pretreatment did not significantly augment the duodenal lesions induced by mepirizole or cysteamine, but did augment the gastric lesions induced by these compounds." | 1.27 | Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin. ( Kuwahara, Y; Okabe, S; Tanaka, H, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, J | 1 |
| Iida, H | 1 |
| Abe, M | 1 |
| Yuda, Y | 1 |
| Inoue, S | 1 |
| Okabe, S | 7 |
| Ishihara, Y | 2 |
| Inoo, H | 1 |
| Tanaka, H | 2 |
| Yamamoto, O | 1 |
| Okada, Y | 1 |
| Yamada, Y | 1 |
| Hata, Y | 1 |
| Tsurumi, K | 1 |
| Kyuki, K | 1 |
| Fujimura, H | 1 |
| Kobayashi, K | 1 |
| Chono, S | 1 |
| Yamada, H | 1 |
| Nishida, A | 1 |
| Takinami, Y | 1 |
| Yuki, H | 1 |
| Kobayashi, A | 1 |
| Akuzawa, S | 1 |
| Kamato, T | 1 |
| Ito, H | 1 |
| Yamano, M | 1 |
| Nagakura, Y | 1 |
| Miyata, K | 1 |
| Sekiguchi, H | 1 |
| Hamada, K | 1 |
| Taga, F | 1 |
| Nishino, K | 1 |
| Yamaguchi, T | 1 |
| Aihara, K | 1 |
| Yamada, S | 1 |
| Narita, S | 1 |
| Kogi, K | 1 |
| Terashima, K | 1 |
| Shimamura, H | 1 |
| Kawase, A | 1 |
| Tanaka, Y | 2 |
| Tanimura, T | 1 |
| Kamisaki, T | 1 |
| Ishizuka, Y | 1 |
| Sato, M | 1 |
| Amagase, K | 1 |
| Kato, S | 1 |
| Yamamoto, H | 1 |
| Renzi, D | 1 |
| Evangelista, S | 1 |
| Mantellini, P | 1 |
| Surrenti, C | 1 |
| Seiki, M | 1 |
| Ueki, S | 1 |
| Soeda, M | 1 |
| Hori, Y | 1 |
| Aita, H | 1 |
| Yoneta, T | 1 |
| Morita, H | 1 |
| Tagashira, E | 1 |
| Tanaka, T | 1 |
| Bickel, M | 1 |
| Herling, AW | 1 |
| Sakurai, M | 1 |
| Goto, M | 1 |
| Hayashi, S | 1 |
| Robert, A | 1 |
| Tabata, K | 1 |
| Joffe, SN | 1 |
| Jacobson, ED | 1 |
| Kuwahara, Y | 1 |
16 other studies available for epirizole and Gastric Ulcer
| Article | Year |
|---|---|
Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Cysteamine; Duodenal | 2004 |
Mepirizole-induced duodenal ulcers in rats and their pathogenesis.
Topics: Administration, Oral; Animals; Antacids; Chemical Phenomena; Chemistry; Dose-Response Relationship, | 1982 |
Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats.
Topics: Animals; Aspirin; Benzimidazoles; Chemical Phenomena; Chemistry; Duodenal Ulcer; Epirizole; Gastric | 1984 |
Species and strain differences in mepirizole-induced duodenal and gastric lesions.
Topics: Animals; Dogs; Duodenal Ulcer; Epirizole; Female; Gastric Juice; Guinea Pigs; Male; Mice; Pyrazoles; | 1983 |
Interaction of indomethacin and aspirin or mepirizole in rats as shown by gastrointestinal ulcerogenic and anti-inflammatory activities.
Topics: Animals; Aspirin; Biological Transport; Charcoal; Drug Interactions; Edema; Epirizole; Indomethacin; | 1980 |
Mepirizole, a non-steroidal antiinflammatory compound, its ulcerogenicity and inhibitory action on lesions induced by acidic antiinflammatory agents in the rat stomach.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Epirizole; Fibrinolysis; Gastri | 1980 |
YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepines; Duodenal Ulcer; Epirizole; Ethanol; Famotidine; Gastric | 1994 |
Effects of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl] urea with potent gastric mucosal protective activity on acute gastric lesions and duodenal ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cyanides; Duodenal Ulcer; Epirizole; Ethanol; Gastric Mucosa; H | 1993 |
Biochemical and pharmacological properties of a newly synthesized proton pump (H+/K(+)-ATPase) inhibitor, TY-11345 in experimental animals.
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Benzimidazoles; Duodenal Ulcer; Epirizole; Ethano | 1993 |
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole; | 1995 |
Effects of the novel histamine H2-receptor antagonist (+/-)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3-[2-[[[5- (methylamino)methyl-2-furyl]methyl]thio]ethyl]-2-(methylsulfonyl) guanidine on gastric secretion and gastroduodenal ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Epirizole; Gastric Acid; Gastric Mucos | 1996 |
Decrease of duodenal calcitonin gene-related peptide- and substance P-like immunoreactivity in rat duodenal ulcers.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cysteamine; Denervation; Duodenal Ulcer; Duoden | 1991 |
[Studies on anti-ulcer effects of a new compound, zinc L-carnosine (Z-103)].
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carnosine; Dogs; Duodenal Ulcer; Epirizole; Ethanol; Gastric Ac | 1990 |
Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Epirizole; Ethanol; Gastric Acid; Gastric Mucosa; Imm | 1989 |
Prostaglandin deficiency by itself is not the cause of mepirizole-induced duodenal ulcers in rats.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Dose-Response Relationship, Drug; Drug Interactions; Duoden | 1987 |
Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin.
Topics: Animals; Cysteamine; Disease Models, Animal; Drug Synergism; Duodenal Ulcer; Epirizole; Histamine; I | 1986 |