epinastine has been researched along with Muscle Contraction in 5 studies
epinastine: RN given refers parent cpd
epinastine : A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An L-type Ca2+ channel blocker, nicardipine, did not suppress the electrical field stimulation-induced smooth muscle contraction and did not alter the inhibitory effect of epinastine." | 3.70 | Effects of epinastine hydrochloride on cholinergic neuro-effector transmission in canine tracheal smooth muscle. ( Aizawa, H; Hara, N; Hirose, T; Inoue, H; Matsumoto, K; Nakano, H; Nishima, S; Takahashi, N, 1998) |
| " In an in vivo experiment, chronic administration of HQL-79 clearly reduced PGD2 contents and enhanced PGE2 contents in the lungs of repeatedly antigen-exposed guinea pigs." | 1.30 | Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. ( Aritake, K; Hayashi, K; Hayashi, M; Hirotsu, I; Hizue, M; Kimura, Y; Matsushita, N; Mitsui, K; Nakajima, H; Takada, A; Tani, T, 1998) |
| "Epinastine (WAL 801CL) is an antihistaminic drug with binding affinity at certain other receptors, including alpha-adrenergic receptors and various serotonin (5-HT) receptor subtypes." | 1.29 | Epinastine (WAL 801CL) modulates the noncholinergic contraction in guinea-pig airways in vitro by a prejunctional 5-HT1-like receptor. ( Demedts, MG; Dupont, LJ; Meade, CJ; Verleden, GM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dupont, LJ | 1 |
| Meade, CJ | 1 |
| Demedts, MG | 1 |
| Verleden, GM | 1 |
| Matsushita, N | 1 |
| Aritake, K | 1 |
| Takada, A | 1 |
| Hizue, M | 1 |
| Hayashi, K | 1 |
| Mitsui, K | 1 |
| Hayashi, M | 1 |
| Hirotsu, I | 1 |
| Kimura, Y | 1 |
| Tani, T | 1 |
| Nakajima, H | 1 |
| Takahashi, N | 1 |
| Aizawa, H | 1 |
| Inoue, H | 1 |
| Matsumoto, K | 1 |
| Nakano, H | 1 |
| Hirose, T | 1 |
| Nishima, S | 1 |
| Hara, N | 1 |
| Kamei, C | 2 |
| Mio, M | 1 |
| Kitazumi, K | 1 |
| Tsujimoto, S | 2 |
| Yoshida, T | 2 |
| Adachi, Y | 1 |
| Tasaka, K | 2 |
| Izushi, K | 1 |
5 other studies available for epinastine and Muscle Contraction
| Article | Year |
|---|---|
Epinastine (WAL 801CL) modulates the noncholinergic contraction in guinea-pig airways in vitro by a prejunctional 5-HT1-like receptor.
Topics: Animals; Bronchi; Dibenzazepines; Female; Guinea Pigs; Histamine H1 Antagonists; Imidazoles; In Vitr | 1996 |
Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antigens; Capillary Permeability; Dibenzazepin | 1998 |
Effects of epinastine hydrochloride on cholinergic neuro-effector transmission in canine tracheal smooth muscle.
Topics: Animals; Calcium Channel Blockers; Cholinergic Agents; Cholinergic Fibers; Dibenzazepines; Dogs; Ele | 1998 |
Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (II). Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects.
Topics: Animals; Bronchoconstriction; Dibenzazepines; Guinea Pigs; Histamine H1 Antagonists; Imidazoles; In | 1992 |
Comparison of pharmacological properties of optical isomers and a racemic mixture of epinastine.
Topics: Animals; Dibenzazepines; Electroencephalography; Guinea Pigs; Histamine; Histamine H1 Antagonists; H | 1991 |