epinastine has been researched along with Hypersensitivity in 5 studies
epinastine: RN given refers parent cpd
epinastine : A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The inhibitory effect of epinastine (WAL 801 CL, CAS 80012-43-7) on types II, III and IV allergic reactions was studied." | 7.68 | Inhibitory effect of epinastine on the type II-IV allergic reactions in mice, rats and guinea pigs. ( Adachi, Y; Izushi, K; Kamei, C; Shimazawa, M; Tasaka, K, 1991) |
| " When leukocytes from asthmatic patients sensitive to mite were stimulated with the allergen, epinastine inhibited histamine release with a concentration required for 50% inhibition (IC50) of 3 x 10(-5) mol/l and leukotriene C4 generation." | 3.69 | Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. ( Mita, H; Shida, T, 1995) |
| "The inhibitory effect of epinastine (WAL 801 CL, CAS 80012-43-7) on types II, III and IV allergic reactions was studied." | 3.68 | Inhibitory effect of epinastine on the type II-IV allergic reactions in mice, rats and guinea pigs. ( Adachi, Y; Izushi, K; Kamei, C; Shimazawa, M; Tasaka, K, 1991) |
| "Epinastine did not inhibit isolated protein kinase C from rat brain." | 1.31 | In vitro investigations with the histamine H1 receptor antagonist, epinastine (WAL 801 CL), on isolated human allergic effector cells. ( Amon, U; Buss, G; Gibbs, BF; Nitschke, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rahman, MA | 1 |
| Inoue, T | 1 |
| Kamei, C | 2 |
| Finegold, I | 1 |
| Granet, DB | 1 |
| D'Arienzo, PA | 1 |
| Epstein, AB | 1 |
| Mita, H | 1 |
| Shida, T | 1 |
| Amon, U | 1 |
| Gibbs, BF | 1 |
| Buss, G | 1 |
| Nitschke, M | 1 |
| Izushi, K | 1 |
| Adachi, Y | 1 |
| Shimazawa, M | 1 |
| Tasaka, K | 1 |
1 trial available for epinastine and Hypersensitivity
| Article | Year |
|---|---|
Efficacy and response with olopatadine versus epinastine in ocular allergic symptoms: a post hoc analysis of data from a conjunctival allergen challenge study.
Topics: Adult; Aged; Dibenzazepines; Dibenzoxepins; Eye Diseases; Female; Humans; Hypersensitivity; Imidazol | 2006 |
4 other studies available for epinastine and Hypersensitivity
| Article | Year |
|---|---|
Role of substance P in allergic nasal symptoms in rats.
Topics: Animals; Antigens; Cyproheptadine; Dibenzazepines; Dibenzoxepins; Dose-Response Relationship, Drug; | 2006 |
Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes.
Topics: Asthma; Calcimycin; Dibenzazepines; Histamine H1 Antagonists; Humans; Hypersensitivity; Imidazoles; | 1995 |
In vitro investigations with the histamine H1 receptor antagonist, epinastine (WAL 801 CL), on isolated human allergic effector cells.
Topics: Basophils; Cell Separation; Dibenzazepines; Eosinophils; Female; Histamine H1 Antagonists; Humans; H | 2000 |
Inhibitory effect of epinastine on the type II-IV allergic reactions in mice, rats and guinea pigs.
Topics: Animals; Arthus Reaction; Dexamethasone; Dibenzazepines; Edema; Erythrocytes; Forssman Antigen; Guin | 1991 |