epiglucan and Squamous-Intraepithelial-Lesions-of-the-Cervix

The aim of this study was to evaluate the effect of β-glucan in women with ASCUS or L-SIL, as detected by cervical cytologic screening.. A total of 356 women with ASCUS or L-SIL were enrolled and divided into two groups: 1) 176 patients, treated with topical β-glucan; and 2) 180 patients who were only followed-up. The treatment consisted of two cycles of topical β-glucan applied once a day for 20 consecutive days and treatment separated by ten days. The effect of β-glucan was evaluated comparing Pap cytology results and colposcopic findings between treated patients and controls after 6 and 12 months of follow-up.. After 6 months from enrollment, 63.1% (111/176) of patients treated with β-glucan had a negative Pap smear versus 45% (81/180) of controls (P<0.001), and 43.4% (36/83) of treated patients versus 18.2% (14/77) of controls experienced the disappearance of colposcopic lesions (P=0.001). At the end of the 12-month follow up, 83.5% (147/176) of treated patients versus 60% (108/180) of controls had a negative Pap smear (P<0.001), and 55.4% (46/83) of treated patients versus 24.7% (19/77) of controls experienced the disappearance of colposcopic lesions (P<0.001). No side effects were observed in treated patients.. β-glucan increases the spontaneous regression rate of low-grade cytologic abnormalities as well as cervical findings.

Topics: Administration, Topical; Adolescent; Adult; Aged; Atypical Squamous Cells of the Cervix; beta-Glucans; Colposcopy; Female; Follow-Up Studies; Humans; Middle Aged; Papanicolaou Test; Squamous Intraepithelial Lesions of the Cervix; Treatment Outcome; Vaginal Smears; Young Adult

Human papillomavirus (HPV) has been directly related to acuminate warts and cervical cancer, the second most common neoplasia among women. Given the lack of treatment against the virus itself, many medications have been utilised, mainly aiming in modifying the host's immunological response. We present the case of a 54 years old postmenopausal patient with a history of vaginal cuff wart and HPV persistence that we managed in our clinic for 6 months with a mix of curcumin, aloe vera, amla and other natural ingredients. As the patient was found to be intolerant to imiquimod (one of the most common conservative methods of treatment) we attempted the use of curcumin, which was applied to the area of the wart three times per week for 6 months. Both clinical and colposcopical improvement was noted in regular clinic visits with regression of the lesion. The outcome of this case encourages our view that curcumin should be considered as a significant treatment modality against HPV infection and acuminate warts.

Topics: Adjuvants, Immunologic; Antineoplastic Agents; beta-Glucans; Colposcopy; Condylomata Acuminata; Curcumin; Drug Combinations; Fatty Alcohols; Female; Humans; Imiquimod; Lactic Acid; Middle Aged; Papanicolaou Test; Papillomavirus Infections; Phyllanthus emblica; Phytotherapy; Plant Preparations; Squamous Intraepithelial Lesions of the Cervix; Vaginal Creams, Foams, and Jellies; Vaginal Diseases; Vaginal Smears