epiglucan and Condylomata-Acuminata

The aim of the study was to examine the effects of beta-glucan treatment in women with recurrent vulvar candidiasis or previously treated with diathermocoagulation (DTC) for vulvar lesions caused by human papillomavirus (HPV) infection.. From January to March 2008, 23 women with a history of recurrent candidiasis and 209 women who underwent to DTC for HPV-correlated vulvar lesions were recruited at the Department of Obstetrics and Gynaeco-logy of San Camillo-Forlanini Hospital of Rome. The two groups were treated with two cycles of a daily topical application of beta-glucan for 15 consecutive days with a suspension of 20 days. The effects of beta-glucan were analyzed at the 1st and the 3rd month from the start of the therapy.. A total of 209 women, 21 with recurrent candidiasis and 188 who underwent to DTC for HPV-correlated lesions, completed the study. After the first month of treatment we not found any evidence of disease in both groups; otherwise we observed, a month after the term of the therapy, 5% and 3% of recurrence of candidiasis or lesions secondary to HPV infection, respectively, even if with low grade.. Our results demonstrate the efficacy of beta-glucan treatment for recurrent candidiasis, HPV-correlated lesions and in the reparative process of epidermis.

Topics: Adjuvants, Immunologic; Administration, Topical; Adult; Alphapapillomavirus; beta-Glucans; Candidiasis, Vulvovaginal; Condylomata Acuminata; Epidermis; Female; Humans; Recurrence; Regeneration; Signal Transduction; Vulvar Diseases; Young Adult

Human papillomavirus (HPV) has been directly related to acuminate warts and cervical cancer, the second most common neoplasia among women. Given the lack of treatment against the virus itself, many medications have been utilised, mainly aiming in modifying the host's immunological response. We present the case of a 54 years old postmenopausal patient with a history of vaginal cuff wart and HPV persistence that we managed in our clinic for 6 months with a mix of curcumin, aloe vera, amla and other natural ingredients. As the patient was found to be intolerant to imiquimod (one of the most common conservative methods of treatment) we attempted the use of curcumin, which was applied to the area of the wart three times per week for 6 months. Both clinical and colposcopical improvement was noted in regular clinic visits with regression of the lesion. The outcome of this case encourages our view that curcumin should be considered as a significant treatment modality against HPV infection and acuminate warts.

Topics: Adjuvants, Immunologic; Antineoplastic Agents; beta-Glucans; Colposcopy; Condylomata Acuminata; Curcumin; Drug Combinations; Fatty Alcohols; Female; Humans; Imiquimod; Lactic Acid; Middle Aged; Papanicolaou Test; Papillomavirus Infections; Phyllanthus emblica; Phytotherapy; Plant Preparations; Squamous Intraepithelial Lesions of the Cervix; Vaginal Creams, Foams, and Jellies; Vaginal Diseases; Vaginal Smears