Compounds > epigallocatechin gallate
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epigallocatechin gallate and Carcinoma, Hepatocellular

epigallocatechin gallate has been researched along with Carcinoma, Hepatocellular in 65 studies

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.54)18.2507
2000's22 (33.85)29.6817
2010's32 (49.23)24.3611
2020's10 (15.38)2.80

Authors

AuthorsStudies
Chen, S; Chen, Y; Fu, L; Zhang, L1
Cai, X; Chen, D; Chen, P; He, X; Hong, Y; Liu, H; Shen, X; Wang, Q; Wang, Y; Zhao, J1
Atmodjo, WL; Irawan, A; Prabowo, E; Riwanto, I1
Jin, J; Sun, H; Wang, M; Yang, H; Zhu, S1
Bajaj, S; Bansal, H; Fayaz, F; Kumar, S; Manchanda, S; Pottoo, FH1
Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S1
Chen, YY; Fu, LX; Gan, RZ; Li, L; Liang, G; Lv, MX; Zhang, XX; Zhou, H; Zhou, JL; Zhu, HQ1
An, H; Cai, Z; Cao, J; Chen, N; Li, K; Li, Y; Luo, A; Peng, Y; Tang, Y; Tao, H1
Fahmi, AA; Gamal-Eldeen, AM; Maksoud, NAE; Mostafa, SM1
Hu, D; Jiang, X; Li, J; Li, Z; Luo, Y; Shang, L; Shen, Y; Yang, C; Zhang, Z1
Chen, F; Cheng, KW; Gowd, V; Kang, Q; Tong, Y; Wang, M1
Chen, H; Chen, Z; Liu, W; Wang, J1
Chen, ZS; Fu, LX; Gupta, P; Liang, G; Liu, BM; Tang, AZ; Wen, Y; Yang, DH; Zhang, YK; Zhao, RQ1
Abdelaziz, AI; Assal, RA; El Tayebi, HM; El-Khatib, AH; Handoussa, H; Linscheid, MW; Shaalan, YM; Youness, RA1
Goto, H; Hayashi, K; Ishida, K; Ishikawa, T; Koide, R; Satonaka, H; Shigemasa, R; Takai, M; Ueyama, J; Wakusawa, S1
Li, H; Pu, H; Sun, Q; Tang, B; Tang, P; Yang, H1
Abdel-Hameed, ND; Abdelaleem, OO; El Amin Ali, AM; Hassouna, A; Khalifa, WA; Mohammed, RA; Sabry, D1
Albino, V; Bimonte, S; Cascella, M; Molino, C; Nasto, A; Palaia, R; Piccirillo, M1
Ahmed, A; Duan, W; Jiang, T; Owusu, L; Xin, Y; Zang, S; Zhang, Y1
Hashimoto, O; Hiroshi, M; Inoue, K; Iwamoto, H; Nakamura, A; Nakamura, T; Sata, M; Torimura, T; Ueno, T1
Deng, C; Guo, T; Li, Y; Ren, X; Wang, Y; Xu, MX; Yan, E; Yang, L1
Feng, Y; Li, J; Luo, X; Shen, X; Xie, YA; Zhang, L; Zhang, Y1
Chen, L; Chen, XZ; Liang, G; Yao, WM; Ye, HL; Zhang, FC; Zhang, G1
Abbas, A; Al-Gayyar, MM; Darweish, MM; Ebrahim, MA1
Duan, W; Owusu, L; Wu, D; Xin, Y; Zhang, Y1
Gao, B; Hu, J; Shu, W; Xiong, S; Zhong, L1
Altoparlak, U; Aydogdu, S; Gundogdu, C; Karamese, M; Karamese, SA1
Ahmad, A; Farhan, M; Hadi, SM; Naseem, I; Rizvi, A1
Arffa, ML; Driver, J; Gupta, GN; Kothari, AN; Kuo, PC; Mi, Z; Wai, PY; Weber, CE; Zapf, MA1
Arakawa, Y; Ikemoto, T; Imura, S; Ishikawa, D; Iwahashi, S; Morine, Y; Saito, Y; Shimada, M; Wubetu, GY; Yamada, S1
Chang, JB; Ho, CT; Liu, JJ; Liu, TZ; Shang, HS1
Heidor, R; Moreno, FS; Pogribny, IP1
Chen, K; Cheng, K; Dai, W; Feng, J; Guo, C; Kong, R; Li, J; Li, S; Liu, T; Lu, J; Wang, F; Wu, L; Xia, Y; Xu, S; Zhang, R; Zhou, S; Zhou, Y1
Freake, H; Kim, Y; Kwun, IS; Lee, MS; Park, JY1
Liang, G; Tang, HH; Zhou, M1
Chan, SH; Cheng, CH; Cheng, GY; Cheung, F; Chui, CH; Gambari, R; Ho, KP; Kok, SH; Lam, KH; Lam, WS; Lau, FY; Tang, JC; Wong, RS1
Berry, DP; Dennison, AR; Garcea, G; Mann, CD; Manson, MM; Neal, CP1
Cao, LQ; Chen, JS; Chen, XL; Fu, XH; Huang, XH; Tan, HX; Wang, Q; Zhen, MC1
Kwok, TT; Tsang, WP1
Henklein, P; Kaufmann, R; Settmacher, U1
Ashida, H; Fukuda, I; Sakane, I; Tsutsui, M1
Adachi, S; Hara, Y; Moriwaki, H; Nakagawa, T; Sakai, H; Shimizu, M; Shirakami, Y; Tsurumi, H; Yasuda, Y1
Huang, CH; Kao, JY; Pan, MH; Tsai, SJ; Wang, YJ; Way, TD1
He, M; Wang, X; Wei, X; Zhang, Z; Zheng, W1
Ardèvol, A; Arola, L; Bladé, C; Blay, M; Bustos, M; Fernández-Larrea, J; Pujadas, G; Quesada, IM; Salvadó, MJ1
Dang, Y; Ding, L; Hu, H; Hu, X; Huang, Q; Huang, W; Ji, X; Jiang, S; Li, J; Liu, JO; Liu, S; Shen, S; Yang, X; Yu, L1
Popovich, DG; Tiaras, F; Yeo, CR; Zhang, W1
Huo, X; Jiang, Y; Li, M; Luo, T; Sun, X; Yin, Y1
Bardag-Gorce, F; French, SW; Oliva, J; Tillman, B1
Chang, Y; He, YF; Hu, SS; Jin, J; Wang, D; Wei, W; Wu, YJ1
Abou El Naga, RN; Ammar, el-SM; Azab, SS; El-Demerdash, E; El-Merzabani, M; Shaarawy, S1
Cederbaum, AI; Jimenez-Lopez, JM1
Huang, ZM; Liang, G; Tang, AZ; Zhang, S1
Bae, JH; Chung, JH; Chung, WJ; Hong, MS; Hwang, JS; Leem, K; Park, HJ; Shin, DH; Yoon, SH1
Ishii, M; Itoh, Y; Jo, M; Kagawa, K; Katagishi, T; Kimura, H; Minami, M; Moriguchi, M; Nakajima, T; Nishikawa, T; Okanoue, T; Sekoguchi, S; Takashima, H1
Le, AD; Lu, Q; Rao, J; Tang, X; Zhang, Q; Zhang, Z1
Ling, MT; Wang, X; Wong, YC; Zhang, X1
Konta, L; Révész, K; Tüttô, A1
Hara, Y; Moriwaki, H; Nakagawa, T; Sakai, H; Shimizu, M; Shirakami, Y; Tatebe, H; Weinstein, IB1
Boo, YC; Kim, HJ; Lee, SI1
Liu, HM; Lu, L; Tang, WX1
Lin, CL; Lin, JK1
Fukutomi, Y; Moriwaki, H; Muto, Y; Ninomiya, M; Nishida, H; Nishiwaki, S; Omori, M; Suganuma, M1
Miura, Y; Yagasaki, K; Zhang, G1
Brackney, W; Denison, MS; Guenette, DK; Pickwell, GV; Quattrochi, LC; Shih, H; Williams, SN1

Reviews

6 review(s) available for epigallocatechin gallate and Carcinoma, Hepatocellular

ArticleYear
Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential.
    Journal of medicinal chemistry, 2022, 10-13, Volume: 65, Issue:19

    Topics: Carcinoma, Hepatocellular; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Interferons; Liver Neoplasms; Nucleotides; Organic Anion Transporters, Sodium-Dependent; Symporters; Virus Internalization

2022
Nanophytomedicine Based Novel Therapeutic Strategies in Liver Cancer.
    Current topics in medicinal chemistry, 2020, Volume: 20, Issue:22

    Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Catechin; Curcumin; Drug Compounding; Drug Stability; Humans; Liver Neoplasms; Nanocapsules; Plant Extracts; Quercetin; Resveratrol; Solubility; Theranostic Nanomedicine

2020
Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives.
    Drug design, development and therapy, 2019, Volume: 13

    Topics: Animals; Carcinoma, Hepatocellular; Catechin; Humans; Liver Neoplasms

2019
Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents.
    Nutrition and cancer, 2016, Volume: 68, Issue:5

    Topics: Animals; Butyric Acid; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Curcumin; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Food; Humans; Isothiocyanates; Phytochemicals; Resveratrol; Stilbenes; Sulfoxides

2016
Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2009, Volume: 18, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Brassicaceae; Caffeine; Capsaicin; Carcinoma, Hepatocellular; Catechin; Chemoprevention; Curcumin; Flavonoids; Humans; Liver Neoplasms; Phenols; Plant Extracts; Polyphenols; Resveratrol; Stilbenes

2009
[Effect of green tea flavonols on the function of the endoplasmic reticulum].
    Orvosi hetilap, 2007, Oct-07, Volume: 148, Issue:40

    Topics: alpha-Glucosidases; Animals; Antineoplastic Agents; Apoptosis; Blood Glucose; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Endoplasmic Reticulum; Flavonols; Glucuronides; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Liver; Liver Neoplasms; Microsomes; Tea

2007

Other Studies

59 other study(ies) available for epigallocatechin gallate and Carcinoma, Hepatocellular

ArticleYear
The Invasive Potential of Hepatoma Cells Induced by Radiotherapy is Related to the Activation of Hepatic Stellate Cells and Could be Inhibited by EGCG Through the TLR4 Signaling Pathway.
    Radiation research, 2022, 04-01, Volume: 197, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Hepatic Stellate Cells; Interleukin-6; Liver Neoplasms; Mice; Signal Transduction; Toll-Like Receptor 4; Tumor Microenvironment

2022
Anti-angiogenic effect of the combination of low-dose sorafenib and EGCG in HCC-induced Wistar rats.
    F1000Research, 2022, Volume: 11

    Topics: Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Rats; Rats, Wistar; Sorafenib; Vascular Endothelial Growth Factor A

2022
Synergetic Effect of EP1 Receptor Antagonist and (-)-Epigallocatechin-3-gallate in Hepatocellular Carcinoma.
    Pharmacology, 2019, Volume: 104, Issue:5-6

    Topics: Alprostadil; Apoptosis; Carcinoma, Hepatocellular; Catechin; Cell Movement; Cell Proliferation; Dinoprostone; Drug Synergism; Hep G2 Cells; Humans; Liver Neoplasms; Receptors, Prostaglandin E, EP1 Subtype; Wound Healing

2019
Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma.
    Cancer prevention research (Philadelphia, Pa.), 2020, Volume: 13, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; Catechin; Cellular Senescence; Diethylnitrosamine; Hepatic Stellate Cells; Liver Cirrhosis; Liver Neoplasms, Experimental; Male; Phenotype; Precancerous Conditions; Rats; Tea; Transcriptome

2020
The epigallocatechin gallate derivative Y6 reduces the cardiotoxicity and enhances the efficacy of daunorubicin against human hepatocellular carcinoma by inhibiting carbonyl reductase 1 expression.
    Journal of ethnopharmacology, 2020, Oct-28, Volume: 261

    Topics: Alcohol Oxidoreductases; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Carcinoma, Hepatocellular; Cardiotoxicity; Catechin; Cell Proliferation; Daunorubicin; Drug Synergism; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Heart Rate; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays

2020
Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A.
    Molecular medicine reports, 2020, Volume: 22, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Catechin; cdc25 Phosphatases; Cell Cycle; Cell Proliferation; Cell Survival; Diethylnitrosamine; Disease Models, Animal; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Tea; Transfection; Tumor Burden

2020
Epigallocatechin gallate-capped gold nanoparticles enhanced the tumor suppressors let-7a and miR-34a in hepatocellular carcinoma cells.
    Anais da Academia Brasileira de Ciencias, 2020, Volume: 92, Issue:4

    Topics: Carcinoma, Hepatocellular; Catechin; Gold; Humans; Liver Neoplasms; Metal Nanoparticles; MicroRNAs

2020
L-EGCG-Mn nanoparticles as a pH-sensitive MRI contrast agent.
    Drug delivery, 2021, Volume: 28, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Contrast Media; Gadolinium DTPA; Hydrogen-Ion Concentration; Liver Neoplasms; Magnetic Resonance Imaging; Manganese; Mice; Nanoparticles; Peritoneal Neoplasms; Proof of Concept Study

2021
Oral administration of EGCG solution equivalent to daily achievable dosages of regular tea drinkers effectively suppresses miR483-3p induced metastasis of hepatocellular carcinoma cells in mice.
    Food & function, 2021, Apr-26, Volume: 12, Issue:8

    Topics: Animals; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Reactive Oxygen Species; Solutions; Tea; Transduction, Genetic

2021
Physicochemical characterization of the oolong tea polysaccharides with high molecular weight and their synergistic effects in combination with polyphenols on hepatocellular carcinoma.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 90

    Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Humans; Liver Neoplasms; Male; Mice; Molecular Weight; Plant Extracts; Polyphenols; Polysaccharides; Tea

2017
Effect of Y6, an epigallocatechin gallate derivative, on reversing doxorubicin drug resistance in human hepatocellular carcinoma cells.
    Oncotarget, 2017, May-02, Volume: 8, Issue:18

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms

2017
Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma.
    Natural product research, 2018, Volume: 32, Issue:18

    Topics: Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Humans; Insulin-Like Growth Factor Binding Protein 2; Liver Neoplasms; MicroRNAs; Quercetin; Tamaricaceae

2018
(-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways.
    Anticancer research, 2017, Volume: 37, Issue:11

    Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Hepatocellular; Catechin; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MAP Kinase Signaling System; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rhodamine 123; Signal Transduction; Tumor Cells, Cultured

2017
Honokiol nanoparticles based on epigallocatechin gallate functionalized chitin to enhance therapeutic effects against liver cancer.
    International journal of pharmaceutics, 2018, Jul-10, Volume: 545, Issue:1-2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Carcinoma, Hepatocellular; Catechin; Cell Proliferation; Chitin; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Liberation; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Kinetics; Lignans; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; Nanoparticles; Nanotechnology; Particle Size; Solubility; Surface Properties; Technology, Pharmaceutical; Tumor Burden; Xenograft Model Antitumor Assays

2018
Anti-proliferative and anti-apoptotic potential effects of epigallocatechin-3-gallate and/or metformin on hepatocellular carcinoma cells: in vitro study.
    Molecular biology reports, 2019, Volume: 46, Issue:2

    Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Catechin; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Glypicans; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; RNA, Long Noncoding; Signal Transduction; Survivin; Vascular Endothelial Growth Factor A

2019
Anti-metastatic and differential effects on protein expression of epigallocatechin-3-gallate in HCCLM6 hepatocellular carcinoma cells.
    International journal of molecular medicine, 2013, Volume: 32, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Catechin; Cell Differentiation; Cell Line, Tumor; Cell Survival; DNA Helicases; DNA-Binding Proteins; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Molecular Chaperones; Neoplasm Metastasis; Nuclear Proteins; Nucleophosmin; Protein Processing, Post-Translational; Proteomics; RNA-Binding Proteins

2013
Methylated-(3'')-epigallocatechin gallate analog suppresses tumor growth in Huh7 hepatoma cells via inhibition of angiogenesis.
    Nutrition and cancer, 2014, Volume: 66, Issue:4

    Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Human Umbilical Vein Endothelial Cells; Humans; Liver Neoplasms; Mice; Mitogen-Activated Protein Kinase 1; Neovascularization, Pathologic; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2014
Mechanism of the inhibition of the STAT3 signaling pathway by EGCG.
    Oncology reports, 2013, Volume: 30, Issue:6

    Topics: Apoptosis; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Molecular Docking Simulation; Phosphorylation; Protein Conformation; Signal Transduction; src Homology Domains; STAT3 Transcription Factor; Surface Plasmon Resonance; Tea

2013
Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway.
    International journal of oncology, 2014, Volume: 44, Issue:3

    Topics: Apoptosis; Carcinoma, Hepatocellular; Catechin; Cell Cycle Checkpoints; Cell Proliferation; Humans; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; S Phase; Signal Transduction

2014
Autophagy inhibition contributes to the synergistic interaction between EGCG and doxorubicin to kill the hepatoma Hep3B cells.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Humans; Liver Neoplasms; Mice; Mice, Nude; Up-Regulation; Xenograft Model Antitumor Assays

2014
Chemopreventive and hepatoprotective effects of Epigallocatechin-gallate against hepatocellular carcinoma: role of heparan sulfate proteoglycans pathway.
    The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:7

    Topics: alpha-Fetoproteins; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Ascorbic Acid; Camellia sinensis; Carcinoma, Hepatocellular; Catechin; Fibroblast Growth Factor 2; Gene Expression; Hep G2 Cells; Heparan Sulfate Proteoglycans; Humans; Liver; Liver Neoplasms; Male; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Phytotherapy; Plant Extracts; Rats, Sprague-Dawley; Syndecan-1; Thioacetamide

2014
Epigallocatechin-3-gallate induces the apoptosis of hepatocellular carcinoma LM6 cells but not non-cancerous liver cells.
    International journal of molecular medicine, 2015, Volume: 35, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Catechin; Cell Cycle; Cell Line, Tumor; Cell Survival; Hepatocytes; Humans; Membrane Potential, Mitochondrial

2015
Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication.
    Cell death & disease, 2015, May-21, Volume: 6

    Topics: Antiviral Agents; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; DNA Replication; DNA, Viral; Hep G2 Cells; Hepatitis B virus; Humans; Liver Neoplasms; Lysosomes; Microtubule-Associated Proteins; Plant Extracts; RNA Interference; RNA, Small Interfering; Tea; Ubiquitin-Activating Enzymes; Viral Core Proteins; Virus Replication

2015
Preventive effects of a major component of green tea, epigallocathechin-3-gallate, on hepatitis-B virus DNA replication.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:10

    Topics: Antioxidants; Camellia sinensis; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; DNA Replication; DNA, Viral; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Liver Neoplasms; Tea; Virus Replication

2015
Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:11

    Topics: Animals; Carcinoma, Hepatocellular; Catechin; Cell Membrane Permeability; Copper; Diethylnitrosamine; DNA Damage; Free Radical Scavengers; Humans; Liver Neoplasms; Oxidative Stress; Rats; Reactive Oxygen Species; Tea

2015
Green tea component epigallocatechin-3-gallate decreases expression of osteopontin via a decrease in mRNA half-life in cell lines of metastatic hepatocellular carcinoma.
    Surgery, 2015, Volume: 158, Issue:4

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Movement; Enzyme-Linked Immunosorbent Assay; Half-Life; Humans; Liver Neoplasms; Neoplasm Metastasis; Osteopontin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2015
Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation.
    Journal of gastroenterology and hepatology, 2016, Volume: 31, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Catechin; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; HCT116 Cells; Hep G2 Cells; Humans; Liver Neoplasms; Neoplastic Stem Cells; Tea

2016
Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma.
    Oncotarget, 2015, Sep-22, Volume: 6, Issue:28

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Culture Media; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Folic Acid; Heat-Shock Proteins; Hep G2 Cells; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Oxidation-Reduction; Reactive Oxygen Species; RNA Interference; Signal Transduction; Survivin

2015
In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity.
    Scientific reports, 2016, 06-28, Volume: 6

    Topics: Aerobiosis; Apoptosis; Carcinoma, Hepatocellular; Catechin; Glycolysis; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Proteins; Phosphofructokinases

2016
Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells.
    The British journal of nutrition, 2008, Volume: 99, Issue:6

    Topics: Analysis of Variance; Camellia sinensis; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cholesterol 7-alpha-Hydroxylase; Dose-Response Relationship, Drug; Gene Expression; Humans; Liver; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Tea

2008
[Impact of epigallocatechin gallate on gene expression profiles of human hepatocellular carcinoma cell lines BEL7404/ADM and BEL7402/5-FU].
    Ai zheng = Aizheng = Chinese journal of cancer, 2008, Volume: 27, Issue:10

    Topics: Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cyclin G1; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Profiling; Humans; Liver Neoplasms; Oligonucleotide Array Sequence Analysis; Vault Ribonucleoprotein Particles

2008
In vitro cytotoxicity of (-)-EGCG octaacetate on MDAMB-231 and SKHep-1 human carcinoma cells: a pharmacological consideration on prodrug design.
    International journal of molecular medicine, 2008, Volume: 22, Issue:6

    Topics: Acetates; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Prodrugs

2008
[Epigallocatechin-3-gallate induces apoptosis in human hepatocellular carcinoma cells].
    Zhonghua yi xue za zhi, 2008, Sep-23, Volume: 88, Issue:36

    Topics: Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Catechin; Cell Line, Tumor; Cyclooxygenase 2; Humans; Liver Neoplasms; Reverse Transcriptase Polymerase Chain Reaction

2008
Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells.
    The Journal of nutritional biochemistry, 2010, Volume: 21, Issue:2

    Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Catechin; DNA Fragmentation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Genes, Reporter; Hep G2 Cells; Humans; Liver Neoplasms; MicroRNAs; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2; Tea; Up-Regulation

2010
Green tea polyphenol epigallocatechin-3-gallate inhibits thrombin-induced hepatocellular carcinoma cell invasion and p42/p44-MAPKinase activation.
    Oncology reports, 2009, Volume: 21, Issue:5

    Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Catechin; Cell Growth Processes; Cell Line, Tumor; Enzyme Activation; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Oligopeptides; Phosphorylation; Receptor, PAR-1; Receptors, Thrombin; Tea; Thrombin

2009
Suppression of cytochrome P450 1A1 expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse hepatoma hepa-1c1c7 cells treated with serum of (-)-epigallocatechin-3-gallate- and green tea extract-administered rats.
    Bioscience, biotechnology, and biochemistry, 2009, Volume: 73, Issue:5

    Topics: Animals; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Down-Regulation; Gene Expression Regulation, Neoplastic; Male; Mice; Plant Extracts; Polychlorinated Dibenzodioxins; Rats; Tea

2009
(-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis.
    Cancer science, 2009, Volume: 100, Issue:10

    Topics: Animals; Anticarcinogenic Agents; bcl-X Protein; Blotting, Western; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2009
EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells.
    Molecular nutrition & food research, 2009, Volume: 53, Issue:9

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Catechin; Cell Cycle; Cell Line, Tumor; Fatty Acid Synthases; Humans; Lipogenesis; Liver Neoplasms; Protein Biosynthesis; Protein Kinases; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53

2009
[Effects of differentially expressed proteins in hepatocellular carcinoma cell treated by different telomerase inhibitors].
    Wei sheng yan jiu = Journal of hygiene research, 2010, Volume: 39, Issue:2

    Topics: Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Enzyme Inhibitors; Humans; Liver Neoplasms; Protein Array Analysis; Proteome; Telomerase; Tretinoin; Zidovudine

2010
Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells.
    The Journal of nutritional biochemistry, 2011, Volume: 22, Issue:2

    Topics: Biflavonoids; Carcinoma, Hepatocellular; Catechin; Cation Transport Proteins; Diet; Gene Expression Regulation; Grape Seed Extract; Hep G2 Cells; Homeostasis; Humans; Interleukin-6; Liver Neoplasms; Metallothionein; Proanthocyanidins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tea; Zinc

2011
Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma.
    Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:2

    Topics: Alcohol Oxidoreductases; Animals; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Catechin; Daunorubicin; Humans; Liver Neoplasms; Mice; Tumor Cells, Cultured

2010
Lovastatin interacts with natural products to influence cultured hepatocarcinoma cell (hep-g2) growth.
    Journal of the American College of Nutrition, 2010, Volume: 29, Issue:3

    Topics: Antineoplastic Agents; Capsaicin; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cells, Cultured; Curcumin; Drug Synergism; Hep G2 Cells; Herb-Drug Interactions; Humans; Liver Neoplasms; Lovastatin; Plant Extracts

2010
The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells.
    Journal of cellular and molecular medicine, 2011, Volume: 15, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 7; Catechin; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Flavonoids; Heat-Shock Proteins; Hep G2 Cells; Humans; Liver Neoplasms; Phosphorylation; Poly(ADP-ribose) Polymerases; Proteasome Inhibitors; Regulatory Factor X Transcription Factors; RNA Interference; Transcription Factors; Unfolded Protein Response

2011
Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitro.
    Experimental and molecular pathology, 2011, Volume: 90, Issue:3

    Topics: Aldehydes; Anti-Infective Agents, Local; Antioxidants; Betaine; Blotting, Western; Carcinoma, Hepatocellular; Catechin; Cells, Cultured; Cytochrome P-450 CYP2E1; Ethanol; Gastrointestinal Agents; Hepatocytes; Humans; In Vitro Techniques; Liver Neoplasms; Malondialdehyde; Oxidative Stress; Quercetin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2011
Prostanoid EP1 receptor as the target of (-)-epigallocatechin-3-gallate in suppressing hepatocellular carcinoma cells in vitro.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:5

    Topics: Alprostadil; Antineoplastic Agents, Phytogenic; Blotting, Western; Bridged Bicyclo Compounds; Caproates; Carcinoma, Hepatocellular; Catechin; Cell Movement; Cell Proliferation; Cell Survival; Dinoprostone; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gq-G11; Hep G2 Cells; Humans; Immunoassay; Liver Neoplasms; Neoplasm Invasiveness; Receptors, Prostaglandin E, EP1 Subtype; Time Factors

2012
Sensitization of TRAIL-induced apoptosis in human hepatocellular carcinoma HepG2 cells by phytochemicals.
    Life sciences, 2013, Mar-21, Volume: 92, Issue:10

    Topics: Apoptosis; Carcinoma, Hepatocellular; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Catechin; DNA Fragmentation; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Indoles; Inhibitory Concentration 50; Liver Neoplasms; Proto-Oncogene Proteins c-bcl-2; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand

2013
Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity.
    Free radical biology & medicine, 2004, Feb-01, Volume: 36, Issue:3

    Topics: Arachidonic Acid; Carcinoma, Hepatocellular; Catalysis; Catechin; Cell Line, Tumor; Cytochrome P-450 CYP2E1; Glutathione; Hepatocytes; Humans; Iron; Lipid Peroxidation; Mitochondria; Phenols; Protective Agents; Reactive Oxygen Species; Tea

2004
[MDR-reversing effect of two components of catechin on human hepatocellular carcinoma BEL-7404/Adr in vitro].
    Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:4

    Topics: Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Liver Neoplasms

2004
Epigallocatechin gallate reduces hypoxia-induced apoptosis in human hepatoma cells.
    Life sciences, 2006, May-08, Volume: 78, Issue:24

    Topics: Antigens, Neoplasm; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cadherins; Carcinoma, Hepatocellular; Catechin; Cell Adhesion Molecules; Cell Hypoxia; Cell Line, Tumor; Coloring Agents; Epithelial Cell Adhesion Molecule; Genes, bcl-2; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Liver Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2006
A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins.
    Journal of hepatology, 2006, Volume: 44, Issue:6

    Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; bcl-X Protein; Camellia sinensis; Carcinoma, Hepatocellular; Caspases; Catechin; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Humans; Liver Neoplasms; Male; Membrane Glycoproteins; Mice; Mice, Inbred Strains; RNA, Messenger; Tea; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays

2006
Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:5

    Topics: Angiogenesis Inhibitors; Anticarcinogenic Agents; Carcinoma; Carcinoma, Hepatocellular; Catechin; Cell Hypoxia; Culture Media; Extracellular Signal-Regulated MAP Kinases; Female; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Plant Extracts; RNA, Messenger; Sirolimus; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A

2006
Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis.
    Cancer science, 2007, Volume: 98, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Cisplatin; Down-Regulation; Doxorubicin; Etoposide; Female; HeLa Cells; Humans; Inhibitor of Differentiation Protein 1; Liver Neoplasms; Male; Mechlorethamine; Methotrexate; Mitomycin; Nasopharyngeal Neoplasms; Paclitaxel; Prostatic Neoplasms; Vincristine

2007
EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells.
    Cancer letters, 2008, Apr-08, Volume: 262, Issue:1

    Topics: Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Proliferation; Hepatocytes; Humans; Liver Neoplasms; Phosphorylation; Receptor, IGF Type 1; Signal Transduction

2008
Effect of green tea and (-)-epigallocatechin gallate on ethanol-induced toxicity in HepG2 cells.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:5

    Topics: Acetylcysteine; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Ethanol; gamma-Glutamyltransferase; Glutathione; Humans; Liver Neoplasms; Plant Extracts; Tea

2008
[Effect of epigallocatechin-3-gallate on the invasiveness of hepatocarcinoma cells in vitro].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2007, Volume: 15, Issue:11

    Topics: Carcinoma, Hepatocellular; Catechin; Cell Adhesion; Cell Survival; Hep G2 Cells; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mucin-1; Neoplasm Invasiveness; Plant Extracts

2007
Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling blockade in human hepG2 hepatoma cells.
    Molecular nutrition & food research, 2008, Volume: 52, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Adenylate Kinase; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Glucose; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction

2008
Inhibitory effects of (-)-epigallocatechin gallate on spontaneous hepatoma in C3H/HeNCrj mice and human hepatoma-derived PLC/PRF/5 cells.
    Japanese journal of cancer research : Gann, 1994, Volume: 85, Issue:3

    Topics: alpha-Fetoproteins; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Carcinoma, Hepatocellular; Catechin; Cell Division; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Tumor Cells, Cultured

1994
Suppression of adhesion and invasion of hepatoma cells in culture by tea compounds through antioxidative activity.
    Cancer letters, 2000, Oct-31, Volume: 159, Issue:2

    Topics: Animals; Antioxidants; Biflavonoids; Carcinoma, Hepatocellular; Catechin; Cell Adhesion; Dose-Response Relationship, Drug; Drug Synergism; Neoplasm Invasiveness; Reactive Oxygen Species; Tea; Tumor Cells, Cultured

2000
Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression.
    Chemico-biological interactions, 2000, Nov-01, Volume: 128, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; Catechin; Cytochrome P-450 CYP1A1; DNA; Gene Expression; Guinea Pigs; Humans; Liver; Liver Neoplasms; Male; Mice; Plant Extracts; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; RNA, Messenger; Tea; Tumor Cells, Cultured

2000