epidermal-growth-factor and Osteomyelitis

The aim of this study was to compare the expression of proliferative markers and apoptosis-associated proteins in the oral mucosa adjacent to bone sequestrum associated with osteonecrosis (ON) of the jaws and florid osseous dysplasia (OD).. Oral mucosal samples derived from surgical procedures performed for treatment of ON and OD (10 cases each) were retrieved. Histologic analysis was done on hematoxylin and eosin-stained slides; immunohistochemical reactions against epidermal growth factor (EGF), keratinocyte growth factor (KGF), vascular endothelial growth factor (VEGF), Bcl-2 protein, interleukin-6 (IL-6), and Ki-67 antigen were performed with the immunoperoxidase technique.. The epithelium was hyperplastic in 60% and 22% of ON and OD samples, respectively. Cytoplasmic EGF and KGF expression; Bcl-2, VEGF, and IL-6 expressions; and the mean epithelial proliferative index were not statistically different between the 2 groups. Membranous EGF expression was more evident in samples showing hyperplastic epithelium.. Exposure to bisphosphonates did not alter the expression of KGF, EGF, VEGF, Bcl-2, IL-6, and the epithelial proliferating index in comparison with inflamed oral mucosa not exposed to bisphosphonates.

Topics: Aged; Biomarkers; Bisphosphonate-Associated Osteonecrosis of the Jaw; Epidermal Growth Factor; Epithelium; Female; Fibroblast Growth Factor 7; Fibrous Dysplasia of Bone; Humans; Immunoenzyme Techniques; Ki-67 Antigen; Male; Middle Aged; Mouth Mucosa; Osteomyelitis; Proto-Oncogene Proteins c-bcl-2; Vascular Endothelial Growth Factor A

Adenoid cystic carcinoma (ACC) is a relatively rare epithelial tumour of the salivary glands in the maxillofacial region. About 40-60% of the patients develop distant metastases, which have been documented most commonly in the lung but also in brain, bone, liver, thyroid, spleen and pancreatic gland.. A 55-year-old women with intraosseous ACC in the mandible mimicking apical periodontitis following curative resection and radiotherapy is presented. Three years later, multiple lung metastases were observed followed by chemotherapy. Five years after curative resection, the patient presented simultaneously with new expansive soft tissue in the pancreas and mammary gland as well as in the kidney found to be metastatic ACC. No case has been reported to date on the manifestation of distant metastases of intraosseous ACC in the breast and the kidney as described by these observations. Metastatic mammary gland ACC stained positive for epithelial growth factor receptor (EGFR) but was negative for HER-2/neu and Cyclooxygenase-2 (COX-2) expression.

Topics: Alveolar Bone Loss; Breast Neoplasms; Carcinoma, Adenoid Cystic; Cyclooxygenase 2; Diagnosis, Differential; Diagnostic Errors; Epidermal Growth Factor; Female; Humans; Hyperbaric Oxygenation; Kidney Neoplasms; Mandibular Neoplasms; Middle Aged; Osteomyelitis; Pancreatic Neoplasms; Periapical Periodontitis; Receptor, ErbB-2; Salivary Gland Neoplasms