epidermal-growth-factor and Mouth-Diseases

Saliva plays an important role in oral health, regulating and maintaining the integrity of the oral hard tissues and soft tissues. This paper reviews the role of saliva in the oral defence mechanisms. The most important salivary immune and non-immune defence proteins and constituents that take part in the pellicle formation and re-mineralisation processes are introduced. General health conditions, medications and salivary gland disorders influencing the defence potential of the saliva are discussed. Treatment possibilities of such conditions, and the future perspective of saliva research is also presented.

Topics: Dental Pellicle; Epidermal Growth Factor; Humans; Mouth Diseases; Oral Health; Saliva; Salivation; Tooth Diseases

A double-blind clinical trial was performed to study the effect of epidermal growth factor (EGF) mouthwash on the healing and recurrence of oral ulceration in 12 patients undergoing cancer chemotherapy. The oral distribution or cytotoxic-induced ulcers corresponded to the salivary gutters. There was no difference in the rate of healing of established ulcers between the experimental and placebo groups. However, there was a small delay in the onset and severity of recurrent ulceration. It was concluded that EGF mouthwash does not accelerate ulcer healing, but it may have the potential to protect the oral epithelium from cytotoxic damage.

Topics: Antineoplastic Agents; Double-Blind Method; Epidermal Growth Factor; Humans; Mouth Diseases; Mouth Mucosa; Mouthwashes; Recombinant Proteins; Ulcer; Wound Healing

Sebaceous adenoma (SA) is a rare solitary tumour with a predilection for the forehead and scalp. In the English literature, less than 10 cases of SA have been described in the oral cavity. The objective of this study was to examine the clinicopathologic features and evaluate the expression of epidermal growth factor and its receptor, estrogen receptor and androgen receptor in SA and in its differential diagnoses including sebaceous gland hyperplasia (SGH) and Fordyce's granules (FG). Additionally, we analysed the proliferative potential of sebaceous cells from SA, SGH and FG by measuring proliferating cell nuclear antigen (PCNA) expression and quantification of argyrophilic nuclear organizer regions (AgNORs). The SA showed many clinicopathologic similarities to cases previously reported including the biphasic population of cells, in the periphery of lobules undifferentiated basaloid cells whereas the central area was formed by mature sebocytes. SA was composed of 198 lobules of sebaceous cells, whereas SGH and FG showed a mean of 21 +/- 7.81 and 5.84 +/- 2.83, respectively. The AgNOR and PCNA indices were similar in SA, SGH and FG. These data suggest that lobule counts may be used as additional criteria in distinguishing SA of the oral cavity from other intraoral sebaceous gland lesions.

Topics: Adenoma; Adolescent; Adult; Aged; Aged, 80 and over; Choristoma; Diagnosis, Differential; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Hyperplasia; Middle Aged; Mouth Diseases; Mouth Neoplasms; Nucleolus Organizer Region; Proliferating Cell Nuclear Antigen; Receptors, Androgen; Receptors, Estrogen; Sebaceous Glands; Sweat Glands