epidermal-growth-factor and Hypokalemia

Topics: Animals; Cell Division; Endocrine Glands; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factors; Growth Substances; Humans; Hypokalemia; Kidney; Platelet-Derived Growth Factor; Sodium; Somatomedins; Transforming Growth Factors

Juxtaglomerular cell tumor (JGCT) is a rare tumor, with approximately 100 cases reported in the literature. The authors respectively studied the clinical data of 11 patients diagnosed with JGCT in Peking Union Medical College Hospital from 2004 to 2014, and investigated the immunohistochemical profiles in 10 tumors. Nine of the 11 patients were diagnosed before the age of 40 years. Hypertension was present in all patients, while hypokalemia occurred in seven of 11 patients. Computed tomography detected JGCTs with a sensitivity of 100%. Immunoreactivities for CD34 and vascular endothelial growth factor were observed in most tumor specimens, suggesting that JGCTs express a variety of vessel-related immunohistochemical markers, although JGCTs are considered a tumor without abundant blood supply. Nuclear accumulation of cyclin D1 was common in JGCTs. Results from immunohistochemistry were negative for BRAF, HER2, and TFE3, suggesting that BRAF, HER2, and TFE3 genes might not play a part in tumorigenesis in JGCTs.

Topics: Adolescent; Adult; Aged; Antigens, CD34; Child; Comorbidity; Epidermal Growth Factor; Female; Humans; Hypertension; Hypokalemia; Juxtaglomerular Apparatus; Kidney Neoplasms; Male; Middle Aged; Retrospective Studies; Tomography, X-Ray Computed; Young Adult