epidermal-growth-factor and Hepatitis--Viral--Human

Strong interest exists about the biomolecular basis of the chronic liver diseases due to viral infections. It seems to be very interesting because of their evolutive potential. In this context the study of oncogenes and oncoproteins could be interesting as prognostic factors for chronic viral diseases of the liver. In this study the authors show the results obtained about EGF and p62 expression in 39 selected patients with cirrhosis and 3 different chronic viral hepatitis (persistent, lobular, and active).

Topics: Biomarkers, Tumor; Biopsy; Chronic Disease; Epidermal Growth Factor; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis, Viral, Human; Hepatocytes; Humans; Liver; Liver Cirrhosis; Prognosis; Proto-Oncogene Proteins c-myc; Receptor, ErbB-2

A large number of growth factors have been described and their action and interaction is proving to be complex. The presence study estimated the epidermal growth factor (EGF) in portal hypertension patients with chronic liver disease due to bilharziasis or viral infection as well as in patients with peptic ulcers. The results showed different statistical values regarding liver cirrhosis, oesophageal varices, and bleeding. No doubt, the EGF was indirectly stimulated by the schistosomal and/or viral infection.

Topics: Epidermal Growth Factor; Hepatitis, Viral, Human; Humans; Hypertension, Portal; Liver Cirrhosis; Peptic Ulcer; Radioimmunoassay; Schistosomiasis