epidermal-growth-factor and Drug-Related-Side-Effects-and-Adverse-Reactions

The Functional Assessment of Cancer Therapy-Epidermal Growth Factor Receptor Inhibitor 18 (FACT-EGFRI-18) is a patient-reported outcomes questionnaire developed to assess the effect of EGFRI on patients. The FACT-EGFR-18 was translated into Dutch and evaluated in order to document that the translation adequately captures the concepts of the original English-language version of the questionnaire and is readily understood by subjects in the target population.. Translation of the FACT-EGFRI-18 from English to Dutch was accomplished by employing the Functional Assessment of Chronic Illness Therapy (FACIT) multilingual translation methodology. Ten native-speaking residents of the target country who reported EGFRI associated dermatological adverse events (dAEs) were asked to review the translation of the harmonized FACT-EGFRI-18.. Participants generally found the Dutch FACT-EGFRI-18 easy to understand and complete. In addition, the translation retained the original meaning of the FACT-EGFRI-18 items and instructions. Based on the results of the cognitive debriefing interviews, no changes to improve clarity and comprehension of translations were identified.. The Dutch FACT-EGFRI-18 demonstrates content validity and linguistic validity, and was found conceptually equivalent to its English source, thus confirming linguistic validation. The results suggest that the Dutch FACT-EGFRI-18 can be applied to measure dAE related health related quality of life in Dutch-speaking patients undergoing EGFRI therapy. Formal validation of the Dutch FACT-EGFRI-18 is ongoing.

Topics: Aged; Comprehension; Drug Eruptions; Drug-Related Side Effects and Adverse Reactions; England; Epidermal Growth Factor; Female; Humans; Linguistics; Male; Middle Aged; Neoplasms; Netherlands; Quality of Life; Risk Assessment; Self Report; Surveys and Questionnaires; Translating; Treatment Outcome

Tubular necrosis induced by various drugs (aminoglycosides, platinum-based anticancer agents) elicits a process of renal tissue repair which involves an increase of cell turnover. The proliferative response remains commensurate with the degree of tubular injury and occurs primarily in the area of tubular epithelium which has suffered injury. After acute renal necrosis, tubular regeneration is associated with a transient dedifferentiation of epithelial cells. This tissue reaction is controlled and leads in most cases to a complete reepithelialization of injured tubules and consequently to a full restoration of normal kidney functions. Recent experimental evidences suggest that EGF (Epidermal growth factor) plays a prominent role in the control of this repair process. By immunocytochemical and biochemical methods we have observed in regenerating kidneys a diminution of the membrane-bound precursor of EGF (prepro-EGF) in distal tubules. Concomitantly, by electron microscopy, EGF immunoreactivity is detected on basolateral membranes of proximal tubules. These experimental data suggest that EGF precursor might be converted into a low molecular weight diffusible factor. The latter is able to interact with the receptors localized on the basolateral membranes of proximal tubules and to induce the tissue repair process.

Topics: Drug-Related Side Effects and Adverse Reactions; Epidermal Growth Factor; Epithelium; Humans; Kidney Tubular Necrosis, Acute; Kidney Tubules; Microscopy, Electron; Protein Precursors; Regeneration