epidermal-growth-factor and Amnesia

1. Human epidermal growth factor (hEGF:0.02-2.0 micrograms) did not affect passive avoidance response or habituation learning when given before or immediately after training, or before retention. 2. hEGF (0.02-2.0 micrograms) failed to influence the scopolamine- or electroconvulsive shock-induced shortening of step-down latency in passive avoidance response when given before or immediately after training, or before retention. 3. These results suggest that the acute administration of hEGF does not affect memory processes as indexed by passive avoidance or habituation learning in normal or amnesic mice.

Topics: Amnesia; Animals; Avoidance Learning; Epidermal Growth Factor; Habituation, Psychophysiologic; Humans; Injections, Intraventricular; Male; Memory; Mice; Mice, Inbred Strains; Reaction Time