epidermal-growth-factor and Acute-Phase-Reaction
epidermal-growth-factor has been researched along with Acute-Phase-Reaction* in 2 studies
Reviews
1 review(s) available for epidermal-growth-factor and Acute-Phase-Reaction
Article | Year |
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Epidermal growth factor and transforming growth factor-beta differently modulate the acute phase response elicited by interleukin-6 in cultured liver cells from man, rat and mouse.
1. Complex effects of principal inflammatory cytokines (IL-6, IL-1, TNF, IFN-gamma) on acute phase protein synthesis and other metabolic processes in cultured liver cells are briefly reviewed. 2. Molecular properties and biological functions of transforming growth factor-beta and epidermal growth factor are compared. 3. The effects of these factors with respect to both amino acid uptake and acute phase protein synthesis are described in detail. The results are found to be different for rat or mouse hepatocytes and human hepatoma cells. Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Cells, Cultured; Epidermal Growth Factor; Growth Substances; Humans; Interleukin-1; Interleukin-6; Liver; Mice; Rats; Transforming Growth Factors; Tumor Necrosis Factor-alpha | 1990 |
Other Studies
1 other study(ies) available for epidermal-growth-factor and Acute-Phase-Reaction
Article | Year |
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Fetal antigen 1 (FA1), a circulating member of the epidermal growth factor (EGF) superfamily: ELISA development, physiology and metabolism in relation to renal function.
We describe an ELISA technique for quantification of fetal antigen 1 (FA1), a glycoprotein belonging to the EGF-superfamily. The ELISA is based on immunospecifically purified polyclonal antibodies and has a dynamic range of 0.7-5.3 ng/ml, intra- and inter-assay C.V.s of less than 3.2% and an average recovery of 105% in serum and 98% in urine. Comparison of FA1 in amniotic fluid, serum and urine revealed parallel titration curves, identical elution volumes following size chromatography, immunological identity and similar profiles when analysed by MALDI-MS. The reference interval for serum FA1 was 12.3-46.6 ng/ml and the levels were 10 times higher in patients with renal failure. FA1 showed no diurnal variation, no variation during the menstrual cycle and was not influenced by the acute phase reaction. In humans (n = 10) the renal clearance of FA1 was 11 ml/min and an identical high renal clearance was found in rats when expressed per 100 g body weight. In rats the initial increase in serum FA1 was 10 ng/ml/h following bilateral nephrectomy, explaining the increased serum concentrations of FA1 observed in patients with renal failure. Topics: Acute-Phase Reaction; Adult; Animals; beta 2-Microglobulin; Chromatography, Affinity; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Glycoproteins; Humans; Kidney; Lymph; Male; Middle Aged; Nephrectomy; Rats; Rats, Inbred Lew; Reference Values; Renal Insufficiency; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1997 |