epidermal-growth-factor and Acquired-Hyperostosis-Syndrome

Angiogenesis is involved in the pathogenesis of arthritis.. The aim of the study was to assess the serum levels of selected angiogenic cytokines and their association with clinical presentation in patients with psoriatic arthritis (PsA) and SAPHO syndrome.. We studied 98 patients: 80 with PsA and 18 with SAPHO syndrome. The following data were recorded: age, sex, disease duration, joint involvement, type of psoriasis, nail involvement, and treatment. The following indices used to assess the activity of PsA and SAPHO were measured: PASI, BASDAI, BASFI, BASMI, BASG, and VAS pain. We determined erythrocyte sedimentation rate, C‑reactive protein (CRP), and platelet count. The serum levels of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), basic and acidic fibroblast growth factors (FGFb and FGFa) were determined using an enzyme‑linked immunosorbent assay.. In patients with PsA, VEGF levels were positively correlated with CRP (P = 0.04), BASFI (P = 0.03), and disease duration (P = 0.007). No differences were found between patients with and without nail psoriasis in the VEGF or EGF levels (P = 0.32 and P = 0.85, respectively). There were no differences between patients with the peripheral and axial forms of arthritis in VEGF or EGF levels (P = 0.56 and P = 0.28, respectively). No significant correlations were observed between EGF and FGF levels and clinical presentation in patients with PsA. In patients with SAPHO, no significant correlations were found between angiogenic cytokine levels and clinical presentation.. Our data suggest a role of VEGF in the pathogenesis of PsA. Further studies are required to better understand the role of angiogenic cytokines in PsA.

Topics: Acquired Hyperostosis Syndrome; Arthritis, Psoriatic; C-Reactive Protein; Cytokines; Epidermal Growth Factor; Female; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Humans; Male; Middle Aged; Platelet Count; Vascular Endothelial Growth Factor A

Se recopilaron datos importantes y coherentes de 187 Estados Partes. Entre ellos, 43 (23,0%) prohibieron la entrada de extranjeros que habían visitado recientemente un país con un nivel generalizado de contagio del ebola y otros 15 (8,0%) impusieron otras restricciones importantes para dichos viajeros: el requisito de obtener un certificado médico que documentara que el individuo no estaba infectado con el virus (

Topics: Acquired Hyperostosis Syndrome; Adult; Arthritis, Psoriatic; Cytokines; Endothelin-1; Epidermal Growth Factor; Female; Humans; Interleukin-18; Interleukin-23; Interleukin-6; Male; Middle Aged; Risk; Spondylitis, Ankylosing; Uveitis, Anterior; Vascular Endothelial Growth Factor A

To assess serum interleukin-6 (IL-6) and interleukin-23 (IL-23) and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome.. We studied 152 spondyloarthritis (SpA) patients: 69 PsA, 61 AS, 22 SAPHO, and 29 controls. We recorded age, sex, disease duration, and treatment. We assessed BASDAI, VAS, and PASI scores. Serum IL-6, IL-23, VEGF, EGF, FGFb, and FGFa levels were determined using ELISA. We estimated ESR and CRP.. Serum IL-6 and IL-23 levels were higher in SpA than in control (P < 0.00001 and P = 0.0004, resp.). There was a positive correlation between serum IL-6 and CRP in AS (P = 0.000001), PsA (P = 0.000001), and SAPHO (P = 0.0003) patients. There was a positive correlation between serum IL-6 and ESR in AS (P = 0.000001), PsA (P = 0.002), and SAPHO (P = 0.02) patients. There was no correlation of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines in SpA.. Serum IL-6 but not serum IL-23 correlated with ESR and CRP in SpA. No correlation was found of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines.

Topics: Acquired Hyperostosis Syndrome; Adult; Arthritis, Psoriatic; Cytokines; Epidermal Growth Factor; Female; Fibroblast Growth Factors; Humans; Interleukin-23; Interleukin-6; Male; Middle Aged; Spondylitis, Ankylosing; Vascular Endothelial Growth Factor A